2020
DOI: 10.18632/aging.103788
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Healthy aging is typified by a progressive and absolute loss of podocytes over the lifespan of animals and humans. To test the hypothesis that a subset of glomerular parietal epithelial cell (PEC) progenitors transition to a podocyte fate with aging, dual reporter PEC-rtTA|LC1|tdTomato | Nphs1-FLPo | FRT-EGFP mice were generated. PECs were inducibly labeled with a tdTomato reporter, and podocytes were constitutively labeled with an EGFP repor… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
24
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 26 publications
(27 citation statements)
references
References 55 publications
3
24
0
Order By: Relevance
“…Therefore, they have a vital role in the glomerulosclerosis mechanism ( Kriz, 2002;Griffin et al, 2003). Hence, the age-related progressive loss of podocytes and the subsequent declines in the expressions of their proteins and markers over the animal and human lifespans have suggested their contribution to glomerulosclerosis (Kaverina et al, 2020). This theory may be extended by our study, as we report a marked significant decline in immunohistochemical abundance of podocin (the podocyte marker that indicates filtration efficiency) and nonsignificant numerical decline in nephrin (the key podocyte slit diaphragm protein) in the aging camels' kidneys.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, they have a vital role in the glomerulosclerosis mechanism ( Kriz, 2002;Griffin et al, 2003). Hence, the age-related progressive loss of podocytes and the subsequent declines in the expressions of their proteins and markers over the animal and human lifespans have suggested their contribution to glomerulosclerosis (Kaverina et al, 2020). This theory may be extended by our study, as we report a marked significant decline in immunohistochemical abundance of podocin (the podocyte marker that indicates filtration efficiency) and nonsignificant numerical decline in nephrin (the key podocyte slit diaphragm protein) in the aging camels' kidneys.…”
Section: Discussionmentioning
confidence: 99%
“…Since several years, there is an ongoing debate whether podocyte progenitor cells exists in or nearby the glomerulus. The groups of Moeller, Romagnani and Shankland have demonstrated that PECs, flat epithelial cells covering the inner side of Bowman's capsule, function as progenitor cells under specific circumstances [4,6,11,[43][44][45]. Therefore, it is of great interest to reveal the mechanisms involved in a possible transformation of PECs into podocyte-like cells as it was described for other cell types like neurons and cardiomyocytes.…”
Section: Discussionmentioning
confidence: 99%
“…Several recent studies highlighted a critical role for the de novo expression of CD9 and, subsequently, of CD44 as a pathogenic switch of PECs from a quiescent to an activated phenotype in CGN and in FSGS [16,51,52], confirming the pathogenic role of PECs in these diseases and offering new molecular targets for glomerular disease therapy. In support of this idea, Kaverina et al showed that PECs lose CD44 expression when differentiating into podocytes in injured glomeruli of old mice, suggesting that a CD44 increase in PECs represents not a regenerative but a pathological transition [53]. In FSGS, CD44 has been shown to have an important role in cell migration toward the injured filtration barrier, where injured podocytes upregulate the migration inhibitory factor (MIF) and stromal cellderived factor 1 (SDF1) that stimulate CD44 expression and CD44-mediated migration [54].…”
Section: Regulators Of Glomerular Progenitors In Pathology: When the Orchestra Is Out Of Tunementioning
confidence: 96%