Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.059 View full text
Dominique J.D. Vanhoutte, Gabriel Vivó-Truyols, Peter J. Schoenmakers

Abstract: The expected performance of spatial ("flat-bed") two-dimensional liquid chromatography ((x)LC×(x)LC) has been calculated using the Pareto-optimality strategy. This approach allowed different objectives (total peak capacity, total analysis time, and total dilution) to be considered simultaneously and to establish optimal parameters (pressure drop, particle size, bed length, and initial spot size). The performance of spatial two-dimensional chromatographic systems was compared with that of conventional on-line, …

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