Parenteral nutrition with fish oil supplements is safe and seems to be effective in severe preterm neonates with respiratory distress syndrome

Béghin, Laurent; Storme, Laurent; Coopman, Stéphanie; Rakza, Thameur; Gottrand, Frédéric

doi:10.1111/apa.13091

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…Beghin et al . reported that fish oil prevented PNAC and lowered bronchopulmonary dysplasia risk in prematurity 33. We have published a paper demonstrating that fish oil alleviates IFALD in children 34.…”

Section: Discussionmentioning

confidence: 93%

“…32 Beghin et al reported that fish oil prevented PNAC and lowered bronchopulmonary dysplasia risk in prematurity. 33 We have published a paper demonstrating that fish oil alleviates IFALD in children. 34 The potential mechanisms are not clear and are likely related to improved bile flow, decreased steatosis and a shift in the eicosanoid profile.…”

Section: Incidence Of Pnacmentioning

confidence: 99%

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Risk factors of parenteral nutrition‐associated cholestasis in very‐low‐birthweight infants

Wang

Yan

Hong

et al. 2020

J Paediatrics Child Health

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Aim: We aimed to explore risk factors associated with parenteral nutrition-associated cholestasis (PNAC) in very-low-birthweight (VLBW) infants. Methods: VLBW infants receiving parenteral nutrition (PN) for at least 14 days were enrolled in a retrospective dual-centre study and divided into two groups chronologically: group A (2000-2007) and group B (2008-2015). The incidence of PNAC and related factors were investigated. We compared the differences between PNAC and non-PNAC groups. A multivariate binary logistic regression analysis was carried out to identify the potential risk factors of PNAC. Results: A total of 387 VLBW infants (53 in group A and 334 in group B) were enrolled in the study. The total incidence of PNAC was 6.7%, 9.4% in group A and 6.3% in group B. The dosage of amino acid (P = 0.009), glucose (P = 0.006), PN calories (P = 0.021) and the ratio of glucose/fat (P = 0.014) were significantly higher in group B than in group A. Non-protein energy to nitrogen ratio (P = 0.017) was lower in group B. Birthweight was significantly lower in the PNAC group than in the non-PNAC group (P = 0.021). Subgroup analysis showed that gestational age and duration of PN were significantly different between the PNAC and non-PNAC groups (P < 0.05). Logistic regression showed that prolonged duration of PN (≥43 days) (odds ratio 3.155, 95% confidence interval 1.009-9.861, P = 0.048) was an independent risk factor of PNAC. Conclusions: For VLBW infants, prolonged duration of PN is a risk factor for the development of PNAC. PNAC may be prevented by weaning off PN as early as possible in VLBW infants.

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Section: Discussionmentioning

confidence: 93%

Section: Incidence Of Pnacmentioning

confidence: 99%

Risk factors of parenteral nutrition‐associated cholestasis in very‐low‐birthweight infants

Wang

Yan

Hong

et al. 2020

J Paediatrics Child Health

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“…The present study allows us to suggest that maternal feeding with PUFA ω-3 can prevent BPD injuries from developing in newborns with a high risk of prematurity. PUFA ω-3 supplementation has recently been studied in human clinics in the situation of severe preterm neonates with respiratory distress syndrome [ 25 ]. It could be interesting to investigate and study the impact of maternal feeding with PUFA ω-3 in the situation of congenital malformation of the diaphragm such as congenital diaphragmatic hernia, which is often associated with a high risk of lung hypoplasia and BPD development.…”

Section: Discussionmentioning

confidence: 99%

Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats

Sharma

Nkembi

Aubry

et al. 2015

IJMS

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Bronchopulmonary dysplasia (BPD) is one of the most common complications of prematurity, occurring in 30% of very low birth weight infants. The benefits of dietary intake of polyunsaturated fatty acids ω-3 (PUFA ω-3) during pregnancy or the perinatal period have been reported. The aim of this study was to assess the effects of maternal PUFA ω-3 supplementation on lung injuries in newborn rats exposed to prolonged hyperoxia. Pregnant female Wistar rats (n = 14) were fed a control diet (n = 2), a PUFA ω-6 diet (n = 6), or a PUFA ω-3 diet (n = 6), starting with the 14th gestation day. At Day 1, female and newborn rats (10 per female) were exposed to hyperoxia (O2, n = 70) or to the ambient air (Air, n = 70). Six groups of newborns rats were obtained: PUFA ω-6/O2 (n = 30), PUFA ω-6/air (n = 30), PUFA ω-3/O2 (n = 30), PUFA ω-3/air (n = 30), control/O2 (n = 10), and control/air (n = 10). After 10 days, lungs were removed for analysis of alveolarization and pulmonary vascular development. Survival rate was 100%. Hyperoxia reduced alveolarization and increased pulmonary vascular wall thickness in both control (n = 20) and PUFA ω-6 groups (n = 60). Maternal PUFA ω-3 supplementation prevented the decrease in alveolarization caused by hyperoxia (n = 30) compared to PUFA ω-6/O2 (n = 30) or to the control/O2 (n = 10), but did not significantly increase the thickness of the lung vascular wall. Therefore, maternal PUFA ω-3 supplementation may protect newborn rats from lung injuries induced by hyperoxia. In clinical settings, maternal PUFA ω-3 supplementation during pregnancy and during lactation may prevent BPD development after premature birth.

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“…Maternal fish consumption during pregnancy and/or lactation has been positively associated with cognitive and visual abilities (11) and reduces the risk of persistent wheeze or asthma (9) in the offspring. Previous work from our laboratory (56) and others (71) also suggested that maternal feeding with PUFA -3 could prevent BPD injuries in rats and could ameliorate the situation of severe preterm neonates (6). However, whether the supplementation could attenuate hyperoxia-induced pulmonary vascular impairment in BPD-associated PH has not been evaluated.…”

Section: L124mentioning

confidence: 97%

Maternal omega-3 PUFA supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring

Zhong

Catheline

Houeijeh

et al. 2018

American Journal of Physiology-Lung Cellular and Molecular Phys

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Pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) affect 16-25% of premature infants with bronchopulmonary dysplasia (BPD), contributing significantly to perinatal morbidity and mortality. Omega-3 polyunsaturated fatty acids (PUFA ω-3) can improve vascular remodeling, angiogenesis, and inflammation under pathophysiological conditions. However, the effects of PUFA ω-3 supplementation in BPD-associated PH are unknown. The present study aimed to evaluate the effects of PUFA ω-3 on pulmonary vascular remodeling, angiogenesis, and inflammatory response in a hyperoxia-induced rat model of PH. From embryonic day 15, pregnant Sprague-Dawley rats were supplemented daily with PUFA ω-3, PUFA ω-6, or normal saline (0.2 ml/day). After birth, pups were pooled, assigned as 12 per litter, randomly assigned to either air or continuous oxygen exposure (fraction of inspired oxygen = 85%) for 20 days, and then euthanized for pulmonary hemodynamic and morphometric analysis. We found that PUFA ω-3 supplementation improved survival, decreased right ventricular systolic pressure and RVH caused by hyperoxia, and significantly improved alveolarization, vascular remodeling, and vascular density. PUFA ω-3 supplementation produced a higher level of total ω-3 in lung tissue and breast milk and was found to reverse the reduced levels of VEGFA, VEGF receptor 2, angiopoietin-1 (ANGPT1), endothelial TEK tyrosine kinase, endothelial nitric oxide synthase, and nitric oxide concentrations in lung tissue and the increased ANGPT2 levels in hyperoxia-exposed rats. The beneficial effects of PUFA ω-3 in improving lung injuries were also associated with an inhibition of leukocyte infiltration and reduced expression of the proinflammatory cytokines IL-1β, IL-6, and TNF-α. These data indicate that maternal PUFA ω-3 supplementation strategies could effectively protect against infant PH induced by hyperoxia.

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Parenteral nutrition with fish oil supplements is safe and seems to be effective in severe preterm neonates with respiratory distress syndrome

Cited by 6 publications

References 15 publications

Risk factors of parenteral nutrition‐associated cholestasis in very‐low‐birthweight infants

Risk factors of parenteral nutrition‐associated cholestasis in very‐low‐birthweight infants

Maternal PUFA ω-3 Supplementation Prevents Neonatal Lung Injuries Induced by Hyperoxia in Newborn Rats

Maternal omega-3 PUFA supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring

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