Parasympathetic Suppression of Manic Symptoms by Physostigmine

The Binding of Some Antidepressant Drugs to Brain Muscarinic Acetylcholine Receptors

“…These values for dissociation constants are in qualitative and quantitative agreement with available published data for tricyclic antidepressant drugs and antipsychotic drugs (Miller & Hiley, 1974;Fjalland, Christensen & Hyttel, 1977;Rehavi et al, 1977;Snyder & Yamamura, 1977). (Janowsky et al, 1973;Snyder & Yamamura, 1977). Some of the drugs tested here e.g.…”

Associations of Acetylcholinesterase Activity with Depression and Anxiety Symptoms among Adolescents Growing Up near Pesticide Spray Sites

“…Alterations in the central cholinergic system may affect neurogenesis and hippocampal function, leading to the cognitive deficits observed in depression (Dagytė et al, 2011). Also concurring with our findings, reversible cholinesterase inhibitors used in clinical practice, such as physostigmine, have been found to induce depressive symptoms and exacerbate mood disorders in normal and manic subjects (Davis et al, 1976;Janowsky et al, 1974Janowsky et al, , 1973Steinberg et al, 1997). Conversely, mood symptoms improved in depressed patients with Alzheimer's disease, after treatment with cholinesterase inhibitors including donepezil (Inoue et al, 2016;Rozzini et al, 2007).…”

Cholinomimetic and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress

“…Rowntree et al [1950] found intensification of depression in his depressed patients, and induction of depression in his manics following DFP administration. Similar findings were noted by Janowsky et al [1973, 19741, Davis et al [1978, and Modestin et al [1973a,b] in actively ill manics given physostigmine, as well as in a larger group of psychiatric patients including depressives and schizoaffectives. Furthermore, Risch et al (unpublished observations) and Nurenberger et al [1982] found that depressives, given either physostigmine or arecoline, also developed depression, as well as anxiety and hostility, and physostigmine was also noted to cause depression in the majority of a group of euthymic bipolar patients maintained on lithium [Oppenheimer et al, 19791.…”