Parasympathectomy induces morphological changes and alters gene-expression profiles in the rat submandibular gland

Kang, Ji-Hyoun; Kim, B.K.; Park, B.I.; Kim, H.J.; Ko, Hyun-Mi; Yang, Shijia; Kim, M.S.; Jung, Ji‐Yeon; Kim, W.J.; Oh, Won-Man; Kim, S.H.; Kim, J.H.

doi:10.1016/j.archoralbio.2009.11.003

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…Salivary gland growth, maintenance, and function are also regulated by autonomic nerves [171]. Both parasympathetic cholinergic signaling through muscarinic receptors, and sympathetic signaling through adrenergic receptors modulates saliva secretion.…”

Section: The Role Of Neurons In Endodermal Tissuesmentioning

confidence: 99%

“…Parasympathetic nerve-derived VIP may also play a role [172]. Though all mechanisms involved have not yet been elucidated, it is known that after denervation the gland undergoes degeneration and atrophy, suggesting that innervation is also crucial for maintenance [171,173–175]. While the role of innervation in salivary gland tumors is unexplored, innervation has been clearly demonstrated to play a key role in cancers of other glandular organs such as the prostate and pancreas, as discussed below.…”

Section: The Role Of Neurons In Endodermal Tissuesmentioning

confidence: 99%

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Neuronal Activity in Ontogeny and Oncology

Venkatesh

Monje

2017

Trends in Cancer

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The nervous system plays a central role in regulating the stem cell niche in many organs and thereby critically modulates development, homeostasis and plasticity. A similarly powerful role for neural regulation of the cancer microenvironment is emerging. Neurons promote the growth of cancers of the brain, skin, prostate, pancreas and stomach. Parallel mechanisms shared in development and cancer suggest that neural modulation of the tumor microenvironment may prove a universal theme, although the mechanistic details of such modulation remain to be discovered for many malignancies. Here, we review what is known about the influences of active neurons on stem cell and cancer microenvironments across a broad range of tissues and discuss emerging principles of neural regulation of development and cancer.

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Section: The Role Of Neurons In Endodermal Tissuesmentioning

confidence: 99%

Section: The Role Of Neurons In Endodermal Tissuesmentioning

confidence: 99%

Neuronal Activity in Ontogeny and Oncology

Venkatesh

Monje

2017

Trends in Cancer

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“…We recently showed that the PSG maintains a reservoir of undifferentiated keratin (K) 5 (+) progenitor cells via an acetylcholine (ACh)/muscarinic (M1) receptor/epidermal growth factor receptor (EGFR)-dependent pathway in the ex vivo embryonic SMG (Knox et al, 2010). Signals from the PSG also control the function of adult SMG and also maintain epithelial architecture, as tissue degeneration results from parasympathetic denervation of rodent or human salivary gland epithelium (Kang et al, 2010; Kyriacou and Garrett, 1988; Mandour et al, 1977). However, it is unclear whether the role of innervation is exclusively to drive progenitor cell proliferation, thereby ensuring a sufficient supply of epithelial cells, or if this role extends to direct regulation of epithelial tubulogenesis (e.g.…”

Section: Introductionmentioning

confidence: 99%

Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland

et al. 2014

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A fundamental question in development is how cells assemble to form a tubular network during organ formation. In glandular organs tubulogenesis is a multistep process requiring coordinated proliferation, polarization and reorganization of epithelial cells to from a lumen, and lumen expansion. Although it is clear that epithelial cells possess an intrinsic ability to organize into polarized structures, the mechanisms coordinating morphogenetic processes during tubulogenesis are poorly understood. Here, we demonstrate that parasympathetic nerves regulate ductal tubulogenesis in the developing salivary gland. We show that the neurotransmitter vasoactive intestinal peptide (VIP) secreted by the innervating ganglia promotes ductal growth, leads to the formation of a contiguous lumen, and facilitates lumen expansion through a cAMP/PKA-dependent pathway. Furthermore, we provide evidence that lumen expansion is independent of apoptosis and involves the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated Cl(−) channel. Thus, parasympathetic innervation coordinates multiple steps in tubulogenesis during organ formation.

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“…The secretion of protein and water in the salivary glands is regulated by parasympathetic and sympathetic nerves. Denervation by parasympathectomy and sympathectomy results in reduction of saliva secretion, and subsequently atrophy, in animal models and humans [ 146 , 147 , 148 , 149 , 150 ]. However, it remains unknown whether denervation or neuronal dysfunction causes the Sjögren’s syndrome-like phenotype.…”

Section: Other Potential Regulatorsmentioning

confidence: 99%

Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands

Suzuki

Iwata

2018

IJMS

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Every day, salivary glands produce about 0.5 to 1.5 L of saliva, which contains salivary proteins that are essential for oral health. The contents of saliva, 0.3% proteins (1.5 to 4.5 g) in fluid, help prevent oral infections, provide lubrication, aid digestion, and maintain oral health. Acinar cells in the lobular salivary glands secrete prepackaged secretory granules that contain salivary components such as amylase, mucins, and immunoglobulins. Despite the important physiological functions of salivary proteins, we know very little about the regulatory mechanisms of their secretion via exocytosis, which is a process essential for the secretion of functional proteins, not only in salivary glands, but also in other secretory organs, including lacrimal and mammary glands, the pancreas, and prostate. In this review, we discuss recent findings that elucidate exocytosis by exocrine glands, especially focusing on the salivary glands, in physiological and pathological conditions.

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Parasympathectomy induces morphological changes and alters gene-expression profiles in the rat submandibular gland

Cited by 13 publications

References 24 publications

Neuronal Activity in Ontogeny and Oncology

Neuronal Activity in Ontogeny and Oncology

Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland

Molecular Regulatory Mechanism of Exocytosis in the Salivary Glands

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