Biochemical Pharmacology volume 76, issue 9, P1155-1164 2008 DOI: 10.1016/j.bcp.2008.08.006 View full text
Chun-Yao Lee, Chien-Hsing Lee, Chien-Cheng Shih, Horng-Huei Liou

Abstract: Parkinson's disease (PD) is a neurodegenerative disease that mainly affects dopaminergic (DA-ergic) neurons in the substantia nigra pars compacta (SNc). Glutamate modulates neuronal excitability, and a high concentration of glutamatergic receptors is found on DA-ergic neurons in the SNc. Paraquat (PQ) is a putative causative agent for PD. Its effects on synaptic glutamate transmission in SNc DA-ergic neurons were evaluated using whole-cell voltage-clamp recording in brain slices from 7- to 14-day-old Wistar ra…

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