Paraneoplastic Relapsing Polychondritis

Cohen, Philip R.

doi:10.1001/archderm.143.7.949

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…Neutrophilic dermatoses have frequently been described in these patients, especially Sweet syndrome–like changes . Therefore, some investigators believe that MDS‐associated RP should be considered a paraneoplastic syndrome , and its poor prognosis might reflect the poor prognosis of MDS per se . The fact that MDS occurred in only men in our series is striking and contrasts with the epidemiology of MDS, with a male:female ratio of ∼1.5 in France .…”

Section: Discussionmentioning

confidence: 62%

Relapsing Polychondritis Can Be Characterized by Three Different Clinical Phenotypes: Analysis of a Recent Series of 142 Patients

Dion

Costédoat-Chalumeau

Sène

et al. 2016

Arthritis & Rheumatology

145

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Section: Discussionmentioning

confidence: 62%

Relapsing Polychondritis Can Be Characterized by Three Different Clinical Phenotypes: Analysis of a Recent Series of 142 Patients

Dion

Costédoat-Chalumeau

Sène

et al. 2016

Arthritis & Rheumatology

145

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“…Myelodysplastic syndrome, other hematologic malignancies, and dyscrasias are the most common coexisting neoplasms with RP 1,21–24 . In addition, skin manifestations have been noted to occur with increased frequency in patients with RP‐associated myelodysplasia 1 .…”

Section: Discussionmentioning

confidence: 99%

“…There have been a few reported cases of solid tumors associated with RP. The associated solid tumor malignancies include breast, 21,24 cervix, 21 bladder, 24 colon, 21 rectum, 24 lung, 21,24 pancreas, 24 vocal cords, 24 prostate, 21 testicles, 21 thyroid, 21 and malignant fibrohistiocytoma 24 …”

Section: Discussionmentioning

confidence: 99%

Annular eruption preceding relapsing polychondritis: case report and review of the literature

2009

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Relapsing polychondritis (RP) is a rare multisystem disorder affecting cartilaginous tissues, primarily of the ears, nose, larynx, and trachea. RP shows dermatologic manifestations in 35-50% of cases, and may show skin findings as the first sign of disease in 12% of affected patients. There have been reports of urticarial-like lesions in RP, typically associated with vasculitis, as well as a few reports of erythema multiforme-like lesions. There has also been one previous report of erythema annulare centrifugum associated with RP, presenting with a histology suggestive of a drug eruption. Our patient presented with urticarial and erythema annulare centrifugum-like plaques preceding the diagnosis of RP by over 1 year, with an initial histology suggestive of a drug eruption.

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“…It may be associated with myelodysplastic syndromes. Pathogenic factors include autoantibodies to type II collagen [4,13] .…”

Section: Arthropathiesmentioning

confidence: 99%

Malignancies in Autoimmune Rheumatic Diseases – A Mini-Review

Szekanecz

Bakó

et al. 2010

Gerontology

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Paraneoplastic symptoms, caused by a malignancy, but not directly related to invasion by the tumor or its metastases, are the result of a wide variety of tumor-derived biologic mediators like hormones, peptides, antibodies, cytotoxic lymphocytes, autocrine and paracrine mediators. Systemic inflammatory rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma or dermatomyositis, may increase the risk for the development of malignancies, predominantly lymphoproliferative disorders. Immunosuppressive drugs and biological agents may also be carcinogenic. However, sustained inflammatory activity seems to be the primary risk factor for malignancies in autoimmune diseases. Tumor-associated antigens may be produced by inflammatory cells and their production may be increased in rheumatoid arthritis and other autoimmune diseases.

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Paraneoplastic Relapsing Polychondritis

Cited by 7 publications

References 4 publications

Relapsing Polychondritis Can Be Characterized by Three Different Clinical Phenotypes: Analysis of a Recent Series of 142 Patients

Relapsing Polychondritis Can Be Characterized by Three Different Clinical Phenotypes: Analysis of a Recent Series of 142 Patients

Annular eruption preceding relapsing polychondritis: case report and review of the literature

Malignancies in Autoimmune Rheumatic Diseases – A Mini-Review

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