Paramètres du stress oxydant dans le diabète de type 2

Kassab, Asma; Laradi, Sandrine; Ferchichi, Salima; Omezzine, Asma; Charfeddine, B.; Ammar, Houssem; Chaieb, L.; Miled, A

doi:10.1016/s0923-2532(03)00007-3

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…18 SPUFA decrease in diabetes can be attributed to LDL peroxidation due to an oxidant stress evidenced by an increased LDL-TBARS. 20,21 In both diabetics and controls, linoleic acid (C18:2; v6)/alpha-linolenic acid (C18:3; v3) ratio exceeded 5, the recommended value in the literature. 22 The emphasis is on the ratio value, rather than their absolute amounts.…”

mentioning

confidence: 95%

Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes

et al. 2008

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Background: We aimed to establish the relationship between glycated haemoglobin (HbA 1c ), hypertension and microalbuminuria onset in type 2 diabetes. We also intended to ascertain the metabolic action of homocysteine on LDL fatty acids and on renal function. Methods: The study was carried out on 200 patients with type 2 diabetes and 200 healthy subjects. HbA 1c , apolipoprotein B (apo B) and microalbuminuria were measured using immunoturbidimetric methods. Cholesterol, peroxide, urea and uric acid were assayed using colorimetric methods. Creatinine clearance was calculated using the Cockroft-Gault equation. Homocysteine was measured by immunological fluorescence polarization. LDL fatty acids were quantified by gas chromatography. Results: Creatinine and microalbuminuria significantly increased in type 2 diabetes when compared with controls. Microalbuminuria was significantly correlated with HbA 1c and with the presence of high blood pressure. Homocysteinaemia significantly correlated with creatinine clearance in diabetes. Linoleic acid (C18:2v6) did not differ between groups. C18:2v6/ C18:3v3 ratio was three times higher in diabetics than in controls. Total saturated fatty acids, homocysteine, H 2 O 2 and LDLthiobarbituric reactive substances significantly increased in microalbuminuric when compared with normoalbuminuric diabetes. Total polyunsaturated fatty acids, arachidonic acid (C20:4v6), LDL-cholesterol, apo B and creatinine clearance significantly decreased in microalbuminuric when compared with normoalbuminuric diabetes. Conclusion: Microalbuminuria onset is associated with renal protein oxidation that is preceded by LDL fatty acid oxidation. The latter is initiated by H 2 O 2 produced from an auto-oxidation of homocysteine and increased metabolism of arachidonic acid towards its pro-inflammatory eicosanoids. An oxidative stress state is the common ground of diffused vasculopathy.

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confidence: 95%

Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes

et al. 2008

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“…Excess of free radicals that naturally occur in mammalian body through oxidative process is known to be involved in several human diseases such as Alzheimer, ageing process, cataracts, cardiovascular diseases, arteriosclerosis, nephritis diabetes mellitus, inflammatory process, rheumatism and DNA damage that can lead to carcinogenesis [5][6][7]. The level of these species produced by mitochondrial respiration, phagocytosis, redox cycles or radiation is maintained by neutralizing excess free radical species by nutritional trappers (vitamin C, E, carotenoids and polyphenols ...) or destruction by various enzyme systems like superoxide dismutases and glutathione peroxidases [5,8].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antioxidant Activity of Launaea Nudicaulis ( Asteraceae ) growing in Southwest of Algeria

Belboukhari¹,

Cheriti²,

Belboukhari³

2014

حوليات العلوم

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ΔγέΪϟ ϩάϬϟ ϲδϴήϟ ϑΪϬϟ ΰϜΗήϳ ϋ ΕΎΒϧ ΕΎμϠΨΘδϤϠϟ ΓΪδϛϸϟ ΓΩΎπϤϟ ΔϴρΎθϨϟ κΤϓ ϰϠ Launaea nudicaulis. ΓΪδϛϸϟ ΓΩΎπϤϟ ΔϳήΒΘΨϤϟ ΔϴρΎθϨϟ Ϧϋ ϱήΤΘϟ ϢΗ ήΤϟ έάΠϟ ϩΎΠΗ ΔϴΣίϹ ΔϴρΎθϨϟ ΔϘϳήρ ϝΎϤόΘγΎΑ DPPH , ΎμϠΨΘδϣ ϥ΄Α ΔϴΣίϹ ΔϴρΎθϨϟ ϩάϬϟ ϲϤϜϟ ϞϴϠΤΘϟ ϦϴΑ n-BuOH ϭ EtOAc ϠΨΘδϤϟ ήΜϛ ΎϤϫ έϭάΠϠϟ ΓΩΎπϣ ΔϴρΎθϧ ΐδϨΑ ΎρΎθϧ ΕΎμ

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“…The Atherogenic Index (AI) is a marker used for identification of a risk for development of cardiovascular disease (17). The higher the risk, the higher the AI value (18). The AI value was calculated as: AI=(Total cholesterol−HDL cholesterol)/HDL cholesterol (17).…”

Section: )mentioning

confidence: 99%

Hypolipidemic effects of hickory nut oil using cold pressure extraction

Zhang

Yao

et al. 2016

Food Sci Biotechnol

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Optimal conditions of hickory nut oil cold press technology were studied. L(3) orthogonal experiment results showed that optimal conditions were a pressing pressure of 15 MPa, pressing temperature of 50°C, pressing cycle of 4 s, and stop cycle of 9 s. Fatty acid compositions were determined using GC-MS and hypolipidemic effects in mice were investigated. Compared to a high fat diet group, hickory nut oil administration decreased serum and visceral total cholesterol, triacylglycerol, and serum low density lipoprotein cholesterol levels. Serum high density lipoprotein cholesterol values were increased. Hickory nut oil can be used as a valuable bioactive source of natural hypolipidemic compounds.

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Paramètres du stress oxydant dans le diabète de type 2

Cited by 6 publications

References 18 publications

Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes

Homocysteine enhances LDL fatty acid peroxidation, promoting microalbuminuria in type 2 diabetes

In Vitro Antioxidant Activity of Launaea Nudicaulis ( Asteraceae ) growing in Southwest of Algeria

Hypolipidemic effects of hickory nut oil using cold pressure extraction

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