2011
DOI: 10.1007/s10404-011-0778-5
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Abstract: Even at low Reynolds numbers, momentum can impact the shape of hydrodynamically focused flow. Both theoretical and experimental characterization of hydrodynamic focusing in microchannels at Reynolds numbers B25 revealed the important parameters that affect the shape of the focused layer. A series of symmetric and asymmetric microfluidic channels with two converging streams were fabricated with different angles of confluence at the junction. The channels were used to study the characteristics of Y-type microcha… Show more

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Cited by 22 publications
(37 citation statements)
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References 38 publications
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“…10 Microfluidics provides a more integrated platform for producing liposomes. 10,11 It additionally provides control of the shape of the interface between converging solutions, 12 of the concentration distributions and gradients, and of the residence times of the solutes. 13 Size and geometry of microfluidic channel influence the size distribution of the resulting liposomes.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…10 Microfluidics provides a more integrated platform for producing liposomes. 10,11 It additionally provides control of the shape of the interface between converging solutions, 12 of the concentration distributions and gradients, and of the residence times of the solutes. 13 Size and geometry of microfluidic channel influence the size distribution of the resulting liposomes.…”
mentioning
confidence: 99%
“…Multiphysics software can predict the shape of hydrodynamically focused solutions in 3D microfluidic geometries, 12 but computation of the effect of cross-stream diffusion at distances downstream requires very fine meshing in order to achieve a mesh-independent result. For long channel lengths, fine meshing leads to intractable computation times and out-of-memory errors.…”
mentioning
confidence: 99%
“…In order to ensure this, a few simulations are run in a full 3D model to investigate the exact flow profiles. In accordance with Nasir et al (2011), a slightly hourglass-formed profile is obtained in the z-direction. Nasir et al's simulations were conducted on a T-junction with only one sheath-flow, but still showed that the shape of the profile depends on both Re and angle between channels, where higher Re and angle increases the amount of sample-fluid pushed towards top and bottom of the channel.…”
Section: Fem Modelingmentioning
confidence: 56%
“…As discussed previously this model does introduce a number of simplifications. Perhaps most notably it takes no account of 3D behavior such as the hourglass profiles discussed in Nasir et al (2011). Such a profile would certainly increase the apparent width of the focusing as seen through topdown imaging and would explain the discrepancy of the calculated with the observed width.…”
Section: Influence Of H On Fmentioning
confidence: 97%
“…Therefore, there were usually intensity variations for the optical signals emitted from the samples located at the different Z-direction positions. 7 To achieve a better confinement for the sample flow in the depth position, Howell et al constructed chevron structures in the micro-channel to focus the sample flow in horizontal and vertical plane. 8 There is also other micro-structures proposed to achieve the 3D focusing in cytometer like the sequential micro-weir structure 9 or positive dielectrophoresis.…”
Section: Introductionmentioning
confidence: 99%