Parameter Estimation for Kinetic Models of Chemical Reaction Networks from Partial Experimental Data of Species’ Concentrations
Manvel Gasparyan,
Shodhan Rao
Abstract:The current manuscript addresses the problem of parameter estimation for kinetic models of chemical reaction networks from observed time series partial experimental data of species concentrations. It is demonstrated how the Kron reduction method of kinetic models, in conjunction with the (weighted) least squares optimization technique, can be used as a tool to solve the above-mentioned ill-posed parameter estimation problem. First, a new trajectory-independent measure is introduced to quantify the dynamical di… Show more
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