Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement

Bellavance, Marie-Andrée; Takatoh, Jun; Lu, Jinghao; Demers, Maxime; Kleinfeld, David; Wang, Fan; Deschênes, Martin

doi:10.1016/j.neuron.2017.07.022

Cited by 19 publications

(21 citation statements)

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“…), which is consistent with a recently described trigeminal–facial reflexive mechanism (Bellavance et al . ). To isolate the piezo responses, we therefore limited the window for spike counts to 30 ms (instead of 75 ms as used previously).…”

Section: Methodsmentioning

confidence: 97%

Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice

Ranjbar-Slamloo

Arabzadeh

2019

The Journal of Physiology

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Key pointsr Sparse population activity is a common feature observed across cortical areas, yet the implications for sensory coding are not clear.r We recorded single neuron activity in the vibrissal somatosensory cortex of awake head-fixed mice using the cell-attached technique.r Unlike the anaesthetised condition, in awake mice a high-velocity, piezo-controlled whisker deflection excited only a small fraction of neurons.r Manual probing of whiskers revealed that the majority of these silent neurons could be activated by specific forms of whisker-object contact.r Our results suggest that sparse coding in vibrissal cortex may be due to high dimensionality of the stimulus space and narrow tuning of individual neurons.Abstract It is widely reported that superficial layers of the somatosensory cortex exhibit sparse firing. This sparseness could reflect weak feedforward sensory inputs that are not sufficient to generate action potentials in these layers. Alternatively, sparseness might reflect tuning to unknown or higher-level complex features that are not fully explored in the stimulus space. Here, we examined these hypotheses by applying a range of vibrotactile and manual vibrissal stimuli in awake, head-fixed mice while performing loose-seal cell-attached recordings from the vibrissal primary somatosensory (vS1) cortex. A high-velocity stimulus delivered by a piezo-electric actuator evoked activity in a small fraction of regular spiking supragranular neurons (23%) in the awake condition. However, a majority of the supragranular regular spiking neurons (84%) were driven by manual stimulation of whiskers. Our results suggest that most neurons in the superficial layers of vS1 cortex contribute to coding in the awake condition when neurons may encounter their preferred feature(s) during whisker-object interactions.

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Section: Methodsmentioning

confidence: 97%

Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice

Ranjbar-Slamloo

Arabzadeh

2019

The Journal of Physiology

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“…The whisker system of rodents provides a useful context for investigating these questions (Kleinfeld et al, 1999; Bosman et al, 2011). Reflexive whisking can be evoked by sensory stimulation, eliciting behaviors that can be controlled and quantified (Bellavance et al, 2017; Nguyen and Kleinfeld 2005). A large portion of the cerebellar cortex is responsive to tactile input to the whiskers, and stimulation of individual whisker follicles alters Purkinje cell activity (Joseph et al, 1978; Armstrong and Drew 1980; Bower and Woolston 1983; Bosman et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Sensorimotor Integration and Amplification of Reflexive Whisking by Well-Timed Spiking in the Cerebellar Corticonuclear Circuit

Brown

Raman

2018

Neuron

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To test how cerebellar crus I/II Purkinje cells and their targets in the lateral cerebellar nuclei (CbN) integrate sensory and motor-related inputs and contribute to reflexive movements, we recorded extracellularly in awake, head-fixed mice during non-contact whisking. Ipsilateral or contralateral air puffs elicited changes in population Purkinje simple spike rates that matched whisking kinematics (∼1 Hz/1° protraction). Responses remained relatively unaffected when ipsilateral sensory feedback was removed by lidocaine but were reduced by optogenetically inhibiting the reticular nuclei. Optogenetically silencing cerebellar output suppressed movements. During puff-evoked whisks, both Purkinje and CbN cells generated well-timed spikes in sequential 2- to 4-ms windows at response onset, such that they alternately elevated their firing rates just before protraction. With spontaneous whisks, which were smaller than puff-evoked whisks, well-timed spikes were absent and CbN cells were inhibited. Thus, sensory input can facilitate millisecond-scale, well-timed spiking in Purkinje and CbN cells and amplify reflexive whisker movements.

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“…Article ll OPEN ACCESS et al, 2019). Likewise, when cerebellar function is impaired, basic muscle activities of breathing and related orofacial behaviors can still take place (Bellavance et al, 2017;Chen et al, 2005;Gewaltig and Diesmann, 2007). Thus, local networks in spinal cord and brainstem are sufficient to generate basic antagonistic muscle activities that mediate rhythmic properties of locomotion and breathing, respectively (Bellavance et al, 2017;Kurnikova et al, 2017;Talpalar et al, 2013;Tresch et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Given the intricate relationships between orofacial behaviors in general and the harmonization of respiratory and whisking behavior in rodents in particular (Kurnikova et al, 2017;Lu et al, 2013;Moore et al, 2013), we wondered how an air puff to the facial whiskers that triggers reflexive whisker protraction (Bellavance et al, 2017;Brown and Raman, 2018;Romano et al, 2018) would also affect the respiratory cycle. To evaluate this, we subjected 12 mice to periodic 0.5-Hz whisker stimulation while measuring their respiration (Figures 3A-3D).…”

Section: Whisker Stimulation Increases the Probability Of A Phase Reset Of Inspirationmentioning

confidence: 99%

Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum

et al. 2020

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Summary The cerebellum is involved in the control of voluntary and autonomic rhythmic behaviors, yet it is unclear to what extent it coordinates these in concert. We studied Purkinje cell activity during unperturbed and perturbed respiration in lobules simplex, crus 1, and crus 2. During unperturbed (eupneic) respiration, complex spike and simple spike activity encode the phase of ongoing sensorimotor processing. In contrast, when the respiratory cycle is perturbed by whisker stimulation, mice concomitantly protract their whiskers and advance their inspiration in a phase-dependent manner, preceded by increased simple spike activity. This phase advancement of respiration in response to whisker stimulation can be mimicked by optogenetic stimulation of Purkinje cells and prevented by cell-specific genetic modification of their AMPA receptors, hampering increased simple spike firing. Thus, the impact of Purkinje cell activity on respiratory control is context and phase dependent, highlighting a coordinating role for the cerebellar hemispheres in aligning autonomic and sensorimotor behaviors.

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Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement

Cited by 19 publications

References 0 publications

Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice

Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice

Sensorimotor Integration and Amplification of Reflexive Whisking by Well-Timed Spiking in the Cerebellar Corticonuclear Circuit

Functional Convergence of Autonomic and Sensorimotor Processing in the Lateral Cerebellum

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