Parallel goal-directed and habitual control of human drug-seeking: Implications for dependence vulnerability.

Hogarth, Lee; Chase, Henry W.

doi:10.1037/a0022913

Cited by 149 publications

(263 citation statements)

References 137 publications

Supporting

Mentioning

228

Contrasting

Order By: Relevance

“…Thus, the capacity of cues to bias choice towards the signalled outcome was autonomous of the devaluation treatments. This dissociation between free-versus cued-choice to outcome devaluation confirms related animal studies (Colwill & Rescorla, 1990;Corbit, et al, 2007;Holland, 2004;Rescorla, 1994) and one human study in which free-choice but not cuedchoice was sensitive to outcome devaluation produced by health warnings (Hogarth & Chase, 2011a). This behavioural dissociation also accords studies which have shown goaldirected and transfer-cue-elicited action to be mediated by dissociable neural substrates (Corbit & Balleine, 2003;Ostlund & Balleine, 2007a).…”

Section: Discussionsupporting

confidence: 84%

“…(1,87) = 37.87, p < .001 (illustrated in Figure 3D), demonstrating greater tobacco preference across both the concurrent and extinction phases as severity/desire increased, confirming the concurrent choice task as an assay of drug value (Hogarth & Chase, 2011a). More importantly, there was a significant interaction between severity/desire, group and block, F…”

Section: Parametric Analysesmentioning

confidence: 53%

“…The design involved administering NRT as the devaluation treatment (versus chocolate satiety) in a procedure otherwise comparable to Hogarth & Chase (2011a). The key predictions were that NRT would modulate goal-directed tobacco choice in the extinction test, indicating that this agent can change the expected value of tobacco.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.

Hogarth

2012

Journal of Experimental Psychology: Animal Behavior Processes

Self Cite

137

View full text Add to dashboard Cite

According to contemporary learning theory, drug-seeking behaviour reflects the summation of two dissociable controllers. Whereas goal-directed drug-seeking is determined by the expected current incentive value of the drug, stimulus-elicited drug-seeking is determined by the expected probability of the drug independently of its current incentive value, and these two controllers contribute additively to observed drug-seeking. One applied prediction of this model is that smoking cessation pharmacotherapies selectively attenuate tonic but not cueelicited craving because they downgrade the expected incentive value of the drug but leave expected probability intact. To test this, the current study examined whether nicotine replacement therapy (NRT) nasal spray would modify goal-directed tobacco choice in a human outcome devaluation procedure, but leave cue-elicited tobacco choice in a Pavlovian to instrumental transfer (PIT) procedure intact. Smokers (n=96) first underwent concurrent choice training in which two responses earned tobacco or chocolate points respectively.Participants then ingested either NRT nasal spray (1mg) or chocolate (147g) to devalue one outcome. Concurrent choice was then tested again in extinction to measure goal-directed control of choice, and in a PIT test to measure the extent to which tobacco and chocolate stimuli enhanced choice of the same outcome. It was found that NRT modified tobacco choice in the extinction test but not the extent to which the tobacco stimulus enhanced choice of the tobacco outcome in the PIT test. This dissociation suggests that the propensity to engage in drug-seeking is determined independently by the expected value and probability of the drug, and that the partial efficacy of pharmacotherapy is due to its selective effect on expected drug value.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Parametric Analysesmentioning

confidence: 53%

See 1 more Smart Citation

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.

Hogarth

2012

Journal of Experimental Psychology: Animal Behavior Processes

Self Cite

137

View full text Add to dashboard Cite

show abstract

“…One such effect was shown directly by Freeman et al (2012), who have found that abstinent smokers were more likely to associate a drug cue with reward than a non-drug cue. Indeed, attentional mechanisms are clearly important in learning (Pearce, 1997;Dayan et al, 2000) and possibly in the maintenance of addiction (Hogarth and Chase, 2011;Hogarth et al, 2013;Wiers et al, 2011).…”

Section: Individual Variability In Addiction Vulnerabilitymentioning

confidence: 99%

The role of learning-related dopamine signals in addiction vulnerability

Huys

Tobler

Hasler

et al. 2014

Progress in Brain Research

View full text Add to dashboard Cite

Psychostimulants such as methylphenidate (MPH) and antidepressants such as fluoxetine (FLX) are widely used in the treatment of various mental disorders or as cognitive enhancers. These medications are often combined, for example, to treat comorbid disorders. There is a considerable body of evidence from animal models indicating that individually these psychotropic medications can have detrimental effects on the brain and behavior, especially when given during sensitive periods of brain development. However, almost no studies investigate possible interactions between these drugs. This is surprising given that their combined neurochemical effects (enhanced dopamine and serotonin neurotransmission) mimic some effects of illicit drugs such as cocaine and amphetamine. Here, we summarize recent studies in juvenile rats on the molecular effects in the mid-and forebrain and associated behavioral changes, after such combination treatments. Our findings indicate that these combined MPH + FLX treatments can produce similar molecular changes as seen after cocaine exposure while inducing behavioral changes indicative of dysregulated mood and motivation, effects that often endure into adulthood. Tables: 2 References: 254 ABSTRACT Dopaminergic signals play a mathematically precise role in reward-related learning, and variations in dopaminergic signalling have been implicated in vulnerability to addiction. Here, we provide a detailed overview of the relationship between theoretical, mathematical and experimental accounts of phasic dopamine signalling, with implications for the role of learning-related dopamine signalling in addiction and related disorders. We describe the theoretical and behavioural characteristics of model-free learning based on errors in the prediction of reward, including step-by-step explanations of the underlying equations. We then use recent insights from an animal model that highlights individual variation in learning during a Pavlovian conditioning paradigm to describe overlapping aspects of incentive salience attribution and model-free learning. We argue that this provides a computationally coherent account of some features of addiction. CONTENTS

show abstract

“…Balleine & Ostlund, 2007). However, evidence on this issue in human participants is mixed: while Hogarth & Chase (2011) found specific PIT remained intact in humans after outcome devaluation, Allman, DeLeon, Cataldo & Johnson (2010) did not.…”

mentioning

confidence: 99%

The effect of conditioned inhibition on the specific Pavlovian-instrumental transfer effect.

Alarcón

Bonardi

2016

Journal of Experimental Psychology: Animal Learning and Cogniti

View full text Add to dashboard Cite

Four experiments examined the effect of Pavlovian conditioned inhibition on specific Pavlovian-instrumental transfer (PIT) in human participants. The task comprised an instrumental phase in which two responses (R 1 , R 2 ) were each paired with one of two outcomes (O 1 , O 2 : R 1 -->O 1 , R 2 -->O 2 ), and a Pavlovian phase, in which two CSs, CS 1 and CS 2 each signalled one of the two outcomes (CS 1 -->O 1 , CS 2 -->O 2 ). In Experiments 1-2 a conditioned inhibitor, X, predicted the omission of one of the outcomes (e.g. CS 1 -->O 1 , CS 1 X-->nothing). In a subsequent test, performance of R 1 and R 2 was examined in the presence of CS 1 and CS 2 . A specific PIT effect was observed: R 1 was performed more than R 2 during CS 1 , and R 2 more than R 1 during CS 2 . This PIT effect was significantly reduced by the presence of the inhibitor X in Experiment 1, in which the Pavlovian phase followed the instrumental phase, and in Experiment 2 in which it preceded it. No such effect was observed when X was presented in the absence of any expectation of the outcomes during the PIT test (Experiment 3a), or when X was trained as a signal for an alternative outcome (Experiment 3b). These results are consistent with the suggestion that the specific PIT effect occurs through a stimulus-outcome-response (S-O-R) mechanism, according to which the CS evokes a representation of the outcome which in turn elicits the response (e.g. CS 1 -->O 1 -->R 1 ). The conditioned inhibitor suppresses performance of the response by suppressing activation of the outcome representation.

show abstract

Parallel goal-directed and habitual control of human drug-seeking: Implications for dependence vulnerability.

Cited by 149 publications

References 137 publications

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.

The role of learning-related dopamine signals in addiction vulnerability

The effect of conditioned inhibition on the specific Pavlovian-instrumental transfer effect.

Contact Info

Product

Resources

About