Paraldehyde Toxicity During Treatment of Status Epilepticus

Bostrom, Bruce

doi:10.1001/archpedi.1982.03970410032006

Arch Pediatr Adolesc Med

1982

DOI: 10.1001/archpedi.1982.03970410032006

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Paraldehyde Toxicity During Treatment of Status Epilepticus

Bruce Bostrom¹

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Cited by 19 publications

(3 citation statements)

References 11 publications

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“…Toxicity has been reported rarely with the use of paraldehyde as an anticonvulsant following intravenous12 13 and intramuscular14 administration. As far as the authors are aware, there are no published reports of toxicity following rectal administration.…”

Section: Discussionmentioning

confidence: 99%

Review of the efficacy of rectal paraldehyde in the management of acute and prolonged tonic-clonic convulsions

Rowland

¹

,

Gill

²

,

Stewart

³

et al. 2009

Archives of Disease in Childhood

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Toxicity has been reported rarely with the use of paraldehyde as an anticonvulsant following intravenous12 13 and intramuscular14 administration. As far as the authors are aware, there are no published reports of toxicity following rectal administration.…”

Section: Discussionmentioning

confidence: 99%

Review of the efficacy of rectal paraldehyde in the management of acute and prolonged tonic-clonic convulsions

Rowland

¹

,

Gill

²

,

Stewart

³

et al. 2009

Archives of Disease in Childhood

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…When using intravenous paraldehyde in children (lm1/25ml saline, given slowly under EEG control to produce basal narcosis), it is rarely necessary to give more than 1 .Oml. The dose suggested by Bostrom (1982) was 200mg/kg, followed by an infusion of 20mg/kg/hour, aiming for a steady serum concentration of 200pg/ ml. This dose should be reduced in the presence of hepatic or pulmonary disease.…”

Section: Paraldehydementioning

confidence: 99%

Status Epilepticus. Ii: Treatment

Brown

¹

,

Hussain

²

1991

Develop Med Child Neuro

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Paraldehyde has been used the longest and there is the most extensive experience with it (Curless et al, 1983;Giacoia et al, 1984). Paraldehyde can contribute to metabolic acidosis and rarely causes pulmonary hemorrhage (Bostrom, 1982). It has no clear advantage over other sedative or hypnotic drugs.…”

Section: Rectal Administration Of Antiepileptic Drugsmentioning

confidence: 99%

Special Pharmacokinetic Considerations in Children

Dodson

¹

1987

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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