Paragonimiasis

Blair, David

doi:10.1007/978-1-4939-0915-5_5

Cited by 33 publications

(43 citation statements)

References 213 publications

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“…[16] Immature forms migrate through the duodenal wall, peritoneal cavity, and diaphragm to become encapsulated and mature within the pulmonary parenchyma, [1] ectopic infections can occur in unexpected regions, including the liver, brain, muscle, and subcutaneous tissues. [17–19] Therefore, symptoms of paragonimiasis were usually variable, as agents of a “neglected tropical disease.” [20] This study is one of the largest retrospective studies investigating the paragonimiasis in children.…”

Section: Discussionmentioning

confidence: 99%

Paragonimiasis in Children in Southwest China

et al. 2017

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Background:Paragonimiasis infection has no specific symptoms or typical radiologic findings, leading to the possibility of misdiagnosis. Thus, the objective of this study was to analyze clinical and radiological features, and treatment outcome of paragonimiasis in children in Southwest China to improve the awareness of this disease.Methods:We retrospectively reviewed the records of children diagnosed with paragonimiasis in West China Second University Hospital between 2005 and 2016. The confirmed diagnosis of paragonimiasis was based on epidemiology history and seropositivity for paragonimiasis and/or detection of paragonimus eggs. Clinical, laboratory, and imaging findings of patients were examined in order to summarize risk factors, clinical characteristics, and treatment outcomes of these patients.Results:A total of 123 patients were included; of them 112 (91.1%) lived in villages and 72 (58.5%) had a history of consuming freshwater crabs. Patients with paragonimiasis most frequently showed respiratory symptoms, including cough (26.0%, 32/123) and tachypnea (16.3%, 20/123), and gastrointestinal symptoms, including abdominal pain (26.8%, 33/123), abdominal distention (22.8%, 28/123), and vomiting (13.0%, 16/123). Laboratory examination showed elevated white blood cell (WBC) counts in the peripheral blood in 89 (72.4%) patients and eosinophilia in 102 (82.9%) patients. Tuberculosis (TB) coinfection was found in 4 (3.3%) patients. Main imaging findings included: effusions (90.4%), lymphadenopathy (40.4%), pulmonary ground-glass opacities (36.2%), cystic lesions (18.1%), and pleural thickening (17.0%). Twenty-nine patients (23.6%) received more than 1 course of praziquantel (PZQ). Additionally, 4 (19.0%) of 21 patients who were discharged from the hospital without complete treatment required rehospitalization for residual serous effusions. Moreover, patients from pericardial effusion group showed longer hospital stays and less elevated WBC counts than those from nonpericardial effusion group.Conclusion:Paragonimiasis should be considered in patients from endemic areas, especially in those with gastrointestinal and/or respiratory symptoms, elevated WBC count, eosinophilia, and serous effusions. Additionally, longer hospital stay may be necessary in cases of paragonimiasis associated with pericardial effusions.

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Section: Discussionmentioning

confidence: 99%

Paragonimiasis in Children in Southwest China

et al. 2017

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“…When the specimen could not reveal the typical characteristics of Paragonimus worm or eggs, molecular approaches, such as PCR can be helpful [17]. Some cases are diagnosed with exposure history, radiological findings, and immunological test.…”

Section: Discussionmentioning

confidence: 99%

“…Praziquantel 25 mg/kg 3 times for 2–3 days are usually used to treat ectopic paragonimiasis, including cerebral paragonimiasis [19]. Surgery is usually performed when the lesions are relatively superficial and easy to remove or when the dead worm accompanied complications [17]. …”

Section: Discussionmentioning

confidence: 99%

A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess

Kim

Lee

et al. 2017

Korean J Parasitol

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Paragonimiasis is a parasitic disease caused by Paragnonimus species. The primary site of infection is the lung, and extrapulmonary involvement is also reported. When infected with Paragonimus westermani, which is the dominant species in Korea, the central nervous system is frequently involved along with the liver, intestine, peritoneal cavity, retroperitoneum, and abdominal wall. Ectopic paragonimiasis raises diagnostic challenge since it is uncommon and may be confused with malignancy or other inflammatory diseases. Here, we report an ectopic paragonimiasis case initially presented with recurrent abdominal pain. The patient developed abdominal pain 3 times for the previous 3 years and the computed tomography (CT) of the abdomen revealed fluid collection with wall enhancement. Recurrent diverticulitis was initially suspected and part of the ascending colon was resected. However, the specimen showed intact colon wall without evidence of diverticulitis and multiple parasite eggs and granulomas were found instead. The size of about 70 μm, the presence of an operculum and relatively thick egg shell suggested eggs of Paragonimus species. With appropriate exposure history and a positive antibody test, the definitive diagnosis was made as peritoneal paragonimiasis.

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“…The epidemiology, pathology and control of the parasites causing the first three diseases in the above list have been reviewed, in the SE Asia context, elsewhere (Sripa et al, 2010). For Paragonimiasis, a recent comprehensive review is available (Blair, 2014), and aspects of the evolution and phylogeography of all four genera have also been reviewed (Attwood, 2010). At the time of writing, there was little published literature regarding decadal climate change and transmission of these infections.…”

Section: Food-borne Trematodesmentioning

confidence: 99%

“…This food-borne parasite consists of over 40 species that infect a wide range of intermediate and definitive hosts (Blair et al, 1999). Nine species or species-complexes are known to affect humans (Blair, 2014;Chai, 2013). The main focus of infection with species of the Paragonimus westermani complex is SE Asia, where multiple individual species within the complex infect intermediate hosts with low specificity (Doanh et al, 2013).…”

Section: Paragonimusmentioning

confidence: 99%

Climate Change and the Neglected Tropical Diseases

Booth

2018

Advances in Parasitology

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Climate change is expected to impact across every domain of society, including health. The majority of the world's population is susceptible to pathological, infectious disease whose life cycles are sensitive to environmental factors across different physical phases including air, water and soil. Nearly all so-called neglected tropical diseases (NTDs) fall into this category, meaning that future geographic patterns of transmission of dozens of infections are likely to be affected by climate change over the short (seasonal), medium (annual) and long (decadal) term. This review offers an introduction into the terms and processes deployed in modelling climate change and reviews the state of the art in terms of research into how climate change may affect future transmission of NTDs. The 34 infections included in this chapter are drawn from the WHO NTD list and the WHO blueprint list of priority diseases. For the majority of infections, some evidence is available of which environmental factors contribute to the population biology of parasites, vectors and zoonotic hosts. There is a general paucity of published research on the potential effects of decadal climate change, with some exceptions, mainly in vector-borne diseases.

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Paragonimiasis

Cited by 33 publications

References 213 publications

Paragonimiasis in Children in Southwest China

Paragonimiasis in Children in Southwest China

A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess

Climate Change and the Neglected Tropical Diseases

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