Paraganglioma (pheochromocytoma) of the posterior mediastinum: a case report and review of the literature

Spector, Jason A.; Willis, David N; Ginsburg, Howard B.

doi:10.1016/s0022-3468(03)00208-2

Cited by 31 publications

(36 citation statements)

References 12 publications

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“…1 Extraadrenal PC, also referred to as paraganglioma, is a rare entity that accounts for approximately 10% of PCs in adults. 2,3 The intrathoracic site is the rarest and accounts for less than 1% of the sites in which PCs can arise.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 The posterior mediastinum is the most common origin of intrathoracic PCs, as reviewed over the past several years. [1][2][3] Although most PCs are catecholamine-secreting, hyperfunctioning tumors, approximately 17% of the patients remain asymptomatic while bearing potentially unstable endocrine tumors, as in the present case. 4 The lack of an endocrinological study limits any discussion of the possible mechanisms that might have preoperatively suppressed the hyperfunction in our case.…”

Section: Discussionmentioning

confidence: 99%

“…6 In addition, scintigraphic localization with 123 I-or 131 I-metaiodobenzylguanidine (MIBG) is highly specifi c for PC and is indicated even in asymptomatic cases. 1,6 Video-endoscopic resections of PCs have recently been reported with increasing frequency, including a large series of infradiaphragmatic tumors. 7 However, the feasibility and validity of video-assisted thoracic surgery (VATS) for intrathoracic PC has yet to be established because of the rarity of the reports on such cases.…”

Section: Discussionmentioning

confidence: 99%

“…1 We herein report a case of posterior mediastinal PC that had been preoperatively normotensive and therefore undiagnosed but caused a sudden rise in blood pressure in response to surgical manipulation of the tumor.…”

Section: Introductionmentioning

confidence: 96%

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Pheochromocytoma of the posterior mediastinum undiagnosed until the onset of intraoperative hypertension

Sakamaki

Yasukawa

Kido

2008

Gen Thorac Cardiovasc Surg

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An asymptomatic 42-year-old man was diagnosed with a posterior mediastinal mass, most likely a nonfunctioning, benign, neurogenic tumor for which thoracoscopic surgery was initially indicated. However, the systemic blood pressure rapidly increased to a critical level immediately after starting the surgical manipulation of the tumor, which was suggestive of a hyperfunctioning pheochromocytoma. The tumor was removed after controlling the blood pressure and was histologically diagnosed as a pheochromocytoma. The patient had an uneventful course, and the tumor was proven to be sporadic through further postoperative investigations. The possibility of extraadrenal pheochromocytoma should be considered in the preoperative diagnosis of an intrathoracic paraaortic tumor, even in an asymptomatic patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Pheochromocytoma of the posterior mediastinum undiagnosed until the onset of intraoperative hypertension

Sakamaki

Yasukawa

Kido

2008

Gen Thorac Cardiovasc Surg

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“…The majority occurs in the posterior mediastinum and there are fewer than 50 reported cases of these tumors within the pericardium in association with heart in the world literature [2]. Extraadrenal pheochromocytomas are more frequent in pediatric than in adult population (30 vs. 10%) [3]. Pheochromocytomas are among the most lethal yet completely curable causes of surgically correctable hypertension.…”

Section: Introductionmentioning

confidence: 99%

A rare cause of hypertension in children: intrathoracic pheochromocytoma

Singh

Rana²,

Sharma

et al. 2008

Pediatr Surg Int

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Mediastinal pheochromocytomas account for only a small fraction of mediastinal tumors. Most commonly, these tumors are located in posterior mediastinum. Increasing number of cases of pheochromocytomas is being reported from middle mediastinum. Excision of mediastinal paraganglioma is often hazardous because of its rich blood supply and tendency to involve surrounding structures. It can be a big challenge to manage asymptomatic cases of pheochromocytoma intraoperatively. It is imperative that these patients receive adequate alpha adrenergic and if necessary beta adrenergic blockade. Adequate preoperative preparation with alpha and beta blockers may not prevent serious intraoperative hypertension. We report a case of posterior mediastinal pheochromocytoma which was biochemically active preoperatively. We review the presentation, diagnosis and management of intrathoracic pheochromocytomas including cardiac pheochromocytomas.

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