Parafoveal Telangiectasis and Diabetic Retinopathy

Neovascular Membranes Associated With Idiopathic Juxtafoveolar Telangiectasis

“…An association between systemic diseases, such as diabetes mellitus, and IJFT has not been well established. The presence of parafoveal telangiectasis and diabetic retinopathy in patients has been previously reported, 7 but the eyes in this series had other manifestations of nonproliferative diabetic retinopathy. Although 7 of the 16 patients in this series had a diagnosis of diabetes mellitus and 1 additional patient had a history of a positive glucose tolerance test, none of these patients had any typical manifestations of diabetic retinopathy.…”

Neovascular Membranes Associated With Idiopathic Juxtafoveolar Telangiectasis

“…An association between systemic diseases, such as diabetes mellitus, and IJFT has not been well established. The presence of parafoveal telangiectasis and diabetic retinopathy in patients has been previously reported, 7 but the eyes in this series had other manifestations of nonproliferative diabetic retinopathy. Although 7 of the 16 patients in this series had a diagnosis of diabetes mellitus and 1 additional patient had a history of a positive glucose tolerance test, none of these patients had any typical manifestations of diabetic retinopathy.…”

Macular Telangiectasia Type 2

“…Also, diabetes mellitus and hypertension could lead to increased vulnerability of the macular vasculature for the eponymous vascular alterations. It had been proposed already in earlier studies that diabetes mellitus may be associated with the disease (Chew et al, 1986;Millay et al, 1986). However, others suggested that the association would not be stronger than expected in an age matched population (Maberley et al, 1999;Yannuzzi et al, 2006).…”

“…diabetic or radiation retinopathy) and that may render capillaries especially sensitive to the effects of VEGF might predispose to such vascular telangiectatic alterations. Accordingly, some studies identified diabetes mellitus, a pathologically decreased glucose tolerance as well as a history of radiation exposure to be associated with MacTel type 2 (Chew et al, 1986;Maberley et al, 1999;Millay et al, 1986). It may be speculated that similar neurosensory atrophic alterations may occur with varying vascular alterations depending on additional factors that modify the susceptibility to develop the vascular phenotype.…”

“…The bilaterality of the disease together with the occurrence in monozygotic twins Hannan et al, 2007;Menchini et al, 2000;Siddiqui and Fekrat, 2005) as well as in siblings and families (Chew et al, 1986;Delaere et al, 2011;Gass and Blodi, 1993;Gillies et al, 2009;Hutton et al, 1978;Isaacs and McAllister, 1996;Oh and Park, 1999;Parmalee et al, 2012) suggests genetic factors in the pathogenesis of MacTel type 2. Vertical transmission in families suggests a dominant inheritance.…”

Morphologic Characteristics of Idiopathic Juxtafoveal Telangiectasia Using Spectral-Domain and Polarization-Sensitive Optical Coherence Tomography

“…[1][2][3] Furthermore, disease-specific characteristics include presence of intraretinal pigmentary changes and deposits. 6,7 Optical coherence tomography (OCT) findings may indicate hyporeflective intraretinal spaces and decreased central retinal thickness values, [8][9][10][11] and intraretinal cysts or partial loss of the highly reflective boundary between the junction between the inner and outer photoreceptor segments (IS/OS junction). 12 Optical coherence tomography, as a noninvasive imaging technique, has become increasingly important as a diagnostic modality in the process of posterior segment evaluation, particularly with the implementation of spectral-domain (SD) technology, 13,14 offering high-resolution raster scan images of central retinal pathology.…”

Neovascular Membranes Associated With Idiopathic Juxtafoveolar Telangiectasis

“…An association between systemic diseases, such as diabetes mellitus, and IJFT has not been well established. The presence of parafoveal telangiectasis and diabetic retinopathy in patients has been previously reported, 7 but the eyes in this series had other manifestations of nonproliferative diabetic retinopathy. Although 7 of the 16 patients in this series had a diagnosis of diabetes mellitus and 1 additional patient had a history of a positive glucose tolerance test, none of these patients had any typical manifestations of diabetic retinopathy.…”

Macular Telangiectasia Type 2

“…Also, diabetes mellitus and hypertension could lead to increased vulnerability of the macular vasculature for the eponymous vascular alterations. It had been proposed already in earlier studies that diabetes mellitus may be associated with the disease (Chew et al, 1986;Millay et al, 1986). However, others suggested that the association would not be stronger than expected in an age matched population (Maberley et al, 1999;Yannuzzi et al, 2006).…”

“…diabetic or radiation retinopathy) and that may render capillaries especially sensitive to the effects of VEGF might predispose to such vascular telangiectatic alterations. Accordingly, some studies identified diabetes mellitus, a pathologically decreased glucose tolerance as well as a history of radiation exposure to be associated with MacTel type 2 (Chew et al, 1986;Maberley et al, 1999;Millay et al, 1986). It may be speculated that similar neurosensory atrophic alterations may occur with varying vascular alterations depending on additional factors that modify the susceptibility to develop the vascular phenotype.…”

“…The bilaterality of the disease together with the occurrence in monozygotic twins Hannan et al, 2007;Menchini et al, 2000;Siddiqui and Fekrat, 2005) as well as in siblings and families (Chew et al, 1986;Delaere et al, 2011;Gass and Blodi, 1993;Gillies et al, 2009;Hutton et al, 1978;Isaacs and McAllister, 1996;Oh and Park, 1999;Parmalee et al, 2012) suggests genetic factors in the pathogenesis of MacTel type 2. Vertical transmission in families suggests a dominant inheritance.…”

Morphologic Characteristics of Idiopathic Juxtafoveal Telangiectasia Using Spectral-Domain and Polarization-Sensitive Optical Coherence Tomography

“…[1][2][3] Furthermore, disease-specific characteristics include presence of intraretinal pigmentary changes and deposits. 6,7 Optical coherence tomography (OCT) findings may indicate hyporeflective intraretinal spaces and decreased central retinal thickness values, [8][9][10][11] and intraretinal cysts or partial loss of the highly reflective boundary between the junction between the inner and outer photoreceptor segments (IS/OS junction). 12 Optical coherence tomography, as a noninvasive imaging technique, has become increasingly important as a diagnostic modality in the process of posterior segment evaluation, particularly with the implementation of spectral-domain (SD) technology, 13,14 offering high-resolution raster scan images of central retinal pathology.…”

Neovascular Membranes Associated With Idiopathic Juxtafoveolar Telangiectasis

“…An association between systemic diseases, such as diabetes mellitus, and IJFT has not been well established. The presence of parafoveal telangiectasis and diabetic retinopathy in patients has been previously reported, 7 but the eyes in this series had other manifestations of nonproliferative diabetic retinopathy. Although 7 of the 16 patients in this series had a diagnosis of diabetes mellitus and 1 additional patient had a history of a positive glucose tolerance test, none of these patients had any typical manifestations of diabetic retinopathy.…”

Macular Telangiectasia Type 2

“…Also, diabetes mellitus and hypertension could lead to increased vulnerability of the macular vasculature for the eponymous vascular alterations. It had been proposed already in earlier studies that diabetes mellitus may be associated with the disease (Chew et al, 1986;Millay et al, 1986). However, others suggested that the association would not be stronger than expected in an age matched population (Maberley et al, 1999;Yannuzzi et al, 2006).…”

“…diabetic or radiation retinopathy) and that may render capillaries especially sensitive to the effects of VEGF might predispose to such vascular telangiectatic alterations. Accordingly, some studies identified diabetes mellitus, a pathologically decreased glucose tolerance as well as a history of radiation exposure to be associated with MacTel type 2 (Chew et al, 1986;Maberley et al, 1999;Millay et al, 1986). It may be speculated that similar neurosensory atrophic alterations may occur with varying vascular alterations depending on additional factors that modify the susceptibility to develop the vascular phenotype.…”

“…The bilaterality of the disease together with the occurrence in monozygotic twins Hannan et al, 2007;Menchini et al, 2000;Siddiqui and Fekrat, 2005) as well as in siblings and families (Chew et al, 1986;Delaere et al, 2011;Gass and Blodi, 1993;Gillies et al, 2009;Hutton et al, 1978;Isaacs and McAllister, 1996;Oh and Park, 1999;Parmalee et al, 2012) suggests genetic factors in the pathogenesis of MacTel type 2. Vertical transmission in families suggests a dominant inheritance.…”

Morphologic Characteristics of Idiopathic Juxtafoveal Telangiectasia Using Spectral-Domain and Polarization-Sensitive Optical Coherence Tomography

“…[1][2][3] Furthermore, disease-specific characteristics include presence of intraretinal pigmentary changes and deposits. 6,7 Optical coherence tomography (OCT) findings may indicate hyporeflective intraretinal spaces and decreased central retinal thickness values, [8][9][10][11] and intraretinal cysts or partial loss of the highly reflective boundary between the junction between the inner and outer photoreceptor segments (IS/OS junction). 12 Optical coherence tomography, as a noninvasive imaging technique, has become increasingly important as a diagnostic modality in the process of posterior segment evaluation, particularly with the implementation of spectral-domain (SD) technology, 13,14 offering high-resolution raster scan images of central retinal pathology.…”