2012
DOI: 10.6061/clinics/2012(01)11 View full text |Buy / Rent full text
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Abstract: OBJECTIVE:Experimental findings support clinical evidence that brain death impairs the viability of organs for transplantation, triggering hemodynamic, hormonal, and inflammatory responses. However, several of these events could be consequences of brain death–associated trauma. This study investigated microcirculatory alterations and systemic inflammatory markers in brain-dead rats and the influence of the associated trauma.METHOD:Brain death was induced using intracranial balloon inflation; sham-operated rats… Show more

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“…; Simas et al . ). Second, BD impairs the endocrine system and decreases the release of hormones, such as triiodothyronine (T3), thyroxine (T4), cortisol and anti‐diuretic hormone, thereby suggesting an interruption along the hypothalamic–pituitary–adrenal axis (Pratschke et al .…”
Section: Discussionmentioning
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“…; Simas et al . ). Second, BD impairs the endocrine system and decreases the release of hormones, such as triiodothyronine (T3), thyroxine (T4), cortisol and anti‐diuretic hormone, thereby suggesting an interruption along the hypothalamic–pituitary–adrenal axis (Pratschke et al .…”
Section: Discussionmentioning
“…; Simas et al . ). Although the release of high levels of catecholamines and adrenal steroids hormones is an essential component of the response to BD, these stress mediators do not have long‐lasting effects, as previously registered in brain‐dead patients and demonstrated in experimental models of BD (Herijgers et al .…”
Section: Discussionmentioning
“…The mechanisms involved in donor organ alterations include hemodynamic instability, hormonal changes, and immunologic alterations such as cytokine release and upregulation of adhesion molecules [18]. Previous studies have shown that BD induces microcirculatory hypoperfusion and leads to increased local inflammation and organ dysfunction [19]. Pathophysiological changes have been demonstrated in many transplantable organs [20] and might be responsible for the BD-mediated deterioration of organ function [21,22].…”
Section: Discussionmentioning
“…5 Intubation was performed from tracheostomy cannula, which was previously generated. The second scintigraphy was performed under intubation and monitored.…”
Section: Brain Deathmentioning