2016
DOI: 10.18632/aging.101007
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Abstract: Aging and exposure to stress would determine the chondrocyte phenotype in osteoarthritis (OA). In particular, chronic inflammation may contribute to stress-induced senescence of chondrocytes and cartilage degeneration during OA progression. Recent studies have shown that adipose-derived mesenchymal stem cells exert paracrine effects protecting against degenerative changes in chondrocytes. We have investigated whether the conditioned medium (CM) from adipose-derived mesenchymal stem cells may regulate senescenc… Show more

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Cited by 45 publications
(40 citation statements)
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References 55 publications
(72 reference statements)
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“…Indeed, previous studies demonstrated that decreased expression of Sirt-1 was observed in mouse and human OA cartilages [23,43]. Furthermore, Platas et al demonstrated that the OA-related catabolic factor, IL-1βreduced the expression of both Sirt-1 mRNA and Sirt-1 protein in chondrocytes [20]. We also found that IL-1β tended to inhibit the expression of Sirt-1 in chondrocytes.…”
Section: Discussionsupporting
confidence: 64%
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“…Indeed, previous studies demonstrated that decreased expression of Sirt-1 was observed in mouse and human OA cartilages [23,43]. Furthermore, Platas et al demonstrated that the OA-related catabolic factor, IL-1βreduced the expression of both Sirt-1 mRNA and Sirt-1 protein in chondrocytes [20]. We also found that IL-1β tended to inhibit the expression of Sirt-1 in chondrocytes.…”
Section: Discussionsupporting
confidence: 64%
“…Sirt-1 has critically-important roles in regulating cellular metabolism and controlling responses to cellular stresses via the regulation of target proteins, and is closely involved in the pathophysiology of stressinduced degenerative diseases including OA [9,13,20,21]. We postulated that cellular stresses could affect cellular energy metabolism through the regulatory mechanism regulated by Sirt-1 as well as AMPK.…”
Section: Discussionmentioning
confidence: 99%
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“…We have previously reported the anti-inflammatory and protective properties of CM from AD-MSC in OA chondrocytes [20, 21]. Despite these studies, the possible contribution of EV to the observed effects is not known.…”
Section: Introductionmentioning
confidence: 99%