Paracoccidioidomicose em crianças em Belém do Pará

Fonseca, Eliane Regine de Souza da; Pardal, Pedro Pereira de Oliveira; Severo, Luiz Carlos

doi:10.1590/s0037-86821999000100006

Cited by 41 publications

(26 citation statements)

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“…Duration of symptoms before the diagnosis and the clinical manifestations of PCM were similar to other studies [2][3]6,9,11,[15][16][17] . Most of the clinical manifestations were related to the reticuloendothelial system, especially lymph node enlargement, hepatomegaly and splenomegaly.…”

Section: Discussionsupporting

confidence: 88%

“…It was originally described by Lutz in 1908 and firstly observed in children by Montenegro, in 1911 26 . PCM is the most important mycosis of Latin America, the endemic area being centered in Brazil, especially in the Southern and Southeastern regions [4][5]11,18,23,25 . Approximately 50 cases have already been described in North America and other countries.…”

Section: Introductionmentioning

confidence: 99%

“…The lack of published reports about this disease in children [2][3]6,9,11,[15][16][17]22 prompted us to report our experience with 63 children less than 15 y old who presented 70 episodes of PCM, admitted to the University Hospital of the State University of Campinas (UNICAMP), São Paulo, Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome

Pereira

Bucaretchi

Barison

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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SUMMARY From February, 1981 to May, 2001, 63 children under 15 y old (ages 2 -15 y, median = 8 y, mean ± 1 SD = 8 ± 3 y) presenting 70 episodes of Paracoccidioidomycosis were admitted. The main clinical manifestations and laboratory features observed upon admission were: lymph node enlargement (87.1%), fever (75.7%), weakness (48.6%), pallor (41.4%), hepatomegaly (40%), splenomegaly (35.7%), anemia (90%), hypergammaglobulinemia (88.5%), eosinophilia (75.5%) and hypoalbuminemia (72.5%). Moderate to severe malnutrition was detected in 35.7% of the episodes (Gomez's criterion). Radiographic and technetium studies showed bone lesions in 20 of the episodes, most of them being multiple lytic lesions, involving both long (70%) and plain bones (30%). First line treatment consisted of an association of sulfametoxazole-trimethoprin, which was used, exclusively, in 50 episodes. Follow-up of hemoglobin levels, number of eosinophils in the peripheral blood, albumin and gammaglobulin serum levels revealed significant sequential improvement one and six months after hospital admission, being quite useful to evaluate treatment effectiveness. Six patients died (9.3%) and four developed sequelae (6.3%) . In conclusion, the juvenile and disseminated forms can be observed in about 70% of the episodes of PCM occurring in children younger than 15 y old, most of them presenting with a febrile lymphoproliferative syndrome associated to anemia, eosinophilia and hypergammaglobulinemia.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome

Pereira

Bucaretchi

Barison

et al. 2004

Rev. Inst. Med. trop. S. Paulo

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“…[6][7][8] Most of clinical manifestations were related to the reticuloendothelial system, such as lymph node enlargement, hepatomegaly and splenomegaly. 9 Lymphadenopaty is the most frequent manifestation followed by fever.…”

Section: Discussionmentioning

confidence: 99%

Juvenile paracoccidioidomycosis in urban area: report of two cases

Carneiro¹,

Miranda²,

Neto³

et al. 2010

Braz J Infect Dis

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We present two cases of juvenile form of paracoccidioidomycosis (PCM), a systemic mycosis frequently found in rural areas, whose prognosis is poor in children and young adults. They are a 14-year-old boy and a 25-year-old woman, both residents in an urban area in São Paulo -Brazil, without any history of travelling to an endemic area. They have been admitted to the hospital due to fever, weight loss and lymphadenopathy. The diagnosis was confirmed by serologic and histopathologic study. Patients have recovered after therapy with oral itraconazole and were discharged from hospital, maintaining outpatient visits. In this article, the authors discuss the unusual presentation of PCM in an urban area.

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“…In this form, which represents 3-5 % of cases of PCM, the first signs of the disease usually arise up to 12 weeks after the beginning of the infection [10]. Cases of subacute PCM were reported by Fonseca et al [36] among children in the city of Belém, Pará State, Brazil, showing that the most frequent symptoms were superficial lymph node enlargement (in 100 % of cases), fever (in 92.3 %), weight loss (in 84.6 %), and increased abdominal volume (in 46 %). Other rare manifestations such as bone marrow necrosis can be seen in acute/subacute PCM, as described by Resende et al [37] in a report of eight patients who were autopsied at Botucatu University Hospital.…”

Section: The Acute/subacute Formmentioning

confidence: 98%

Epidemiology, Clinical, and Therapeutic Aspects of Paracoccidioidomycosis

Costa

Silva²

2014

Curr Trop Med Rep

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Paracoccidioidomycosis, or PCM, was described by Adolfo Lutz 105 years ago. Since then the disease has taken a prominent position among the systemic fungal infections because it mainly affects individuals in the most productive years of their lives in various countries of Latin America. In Brazil, the disease is considered endemic in some regions. However, it is still a neglected disease. With the recent discovery that Paracoccidioides brasiliensis is not the only species of this genus, numerous studies have contributed to better understanding and recognition of this pathogen and its pathology in many aspects, such as the epidemiological, clinical, and therapeutic aspects.

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Paracoccidioidomicose em crianças em Belém do Pará

Cited by 41 publications

References 1 publication

Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome

Paracoccidioidomycosis in children: clinical presentation, follow-up and outcome

Juvenile paracoccidioidomycosis in urban area: report of two cases

Epidemiology, Clinical, and Therapeutic Aspects of Paracoccidioidomycosis

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