Papulopustular eruption after intravitreal bevacizumab (Avastin^®)

Acneiform Eruption in a Patient Receiving Bevacizumab for Glioblastoma Multiforme

“…Nonspecific skin eruption has been reported in some patients receiving bevacizumab, and recently, bevacizumab-associated acneiform eruption was reported in the treatment of colon cancer (systemic administration) and macular degeneration (intravitreal administration). 1-3 The eruption in these patients was strikingly similar to that characterized in patients treated with epidermal growth factor receptor (EGFR) inhibitors. 1-4 We report a case of bevacizumab-induced acneiform eruption in a patient with glioblastoma multiforme.…”

“…1-3 However, in the case of bevacizumab, the pathophysiologic characteristics of this cutaneous reaction are poorly understood. Current theories speculate that a blockade of EGFR signaling in the skin and hair follicles results in subsequent abnormal differentiation and proliferation (EGFR is a growth factor for the epidermis and epidermal appendages).…”

“…In the 3 reported cases of follicular eruption associated with bevacizumab that we found in the literature, the authors proposed that improvement of the patients’ disease was related to the development of the eruption. 1-3 …”

Hedefe Yönelik Kemoterapi İlaçlarına Bağlı Akneiform Döküntü ve Eşlik Eden Diğer Dermatolojik Yan Etkiler: Retrospektif Bir Değerlendirme

“…Çalışmamızda bir hastada everolimusa bağlı akneiform döküntü görüldü. Bevasizumab vasküler endotelyal büyüme faktörü (VEBF) inhibitörü olup az sayıda olguda akneiform döküntü yapıcı yan etkisi bildirilmiştir 10,11 . VEBF, kıl folikülü hücreleri, keratinositler ve endotelyal hücreler için büyüme faktörü olduğundan bu ilaçla ortaya çıkan dermatolojik yan etkilerin EBFR inhibitörlerine bağlı akneiform döküntü ile aynı mekanizma sonucu oluştuğu öne sürülmüştür 10 .…”

Becker Nevus With Ichthyotic Features

“…2 Most cases are unilateral and occur on the shoulder, scapula, or chest, although any site may be affected. 3 The average size is estimated to be between 125 and 230 cm 2 . 4 Although hypertrichosis is a characteristic finding, it may be subtle and difficult to appre-ciate in some cases.…”