Papular xanthoma. A clinical, histologic, and ultrastructural study

Papular Xanthoma

“…In our case iron staining was negative as were S-100 protein and lysozyme reactions: so it seems to us that these stains cannot be relied upon to differentiate PX from other entities. Ultrastructurally our case showed a picture similar to that ob served by Sanchez et al [5]: the infiltrate cells are macrophages packed with free intracytoplasmic lipidic droplets; the only difference was that lipidic vacuoles were not electron-dense and myelinated and lam inat ed bodies were completely absent. However in the case of Sanchez et al the latter were so abundant that they claimed that they could be a characteristic marker of PX, a finding we cannot substantiate.…”

Congenital papular xanthoma

“…Sanchez et al . 2 suggested that laminated bodies are cytoplasmic markers of papular xanthoma, like other non‐X histiocytoses, but these were not found in our patient or in other reported cases. 4 , 6…”

Generalized eruptive histiocytoma: an ultrastructural study

“…The cytoplasm of tumor cells in GEH has been reported to contain a large number of dense bodies, often appearing as laminated, and possibly deriving from Golgi apparatus (2). In the present case, several similar laminated bodies were found; however, they have been observed not only in GEH and SHR but also in PX (7). The structures which appear annular in section seem to be unique to the present case.…”