Papular-Purpuric 'Gloves and Socks' Syndrome Associated With Human Herpesvirus 6 Infection

The juvenile variant of papular-purpuric gloves and socks syndrome and its association with viral infections

“…Oral erosions were present in only one case, and none had fever or palpable lymphadenopathy. The mean duration of skin eruption is 4·8 weeks, a little longer than that of PPGSS in adults (about 2 weeks) 1–9 . The peak incidence in the last quarter of the year is also different 8 .…”

A girl with a purpuric rash (Discussion and Diagnosis)

“…Two‐thirds of the PPGSS cases have been associated with acute PVB19 infection (3,4), the rest being associated with other viruses (CMV, EBV, measles, HHV‐6, HBV, VZV and coxsackievirus B) or drugs (thrimethoprim/sulfomethoxazole) (3,5,13). The pathogenesis of the manifestations in PPGSS remains unclear (5).…”

“…There is a vascular reaction against cells that may express viral antigens (10). HHV‐6 and HHV‐7 can augment such local cytotoxic reactions (13,14). PVB19 DNA was found in epidermal and endothelial cells that correlate with a lymphocytic and perivascular infiltrate with evidence of red cell extravasation (4,10).…”

Generalized petechial eruption induced by parvovirus B19 infection

“…3 It is usually spread through the respiratory route and is more prevalent in school-age children in the late winter and early spring months. 2 The incubation phase of parvovirus B19 is between 13 to 17 days. Patients are normally asymptomatic or experience a nonspecific prodrome (fever, sore throat, myalgias and/or arthralgias) as a result of the viremia.…”

“…6 Cases of PPGSS occur mostly in the late spring and summer months, which differs from EI. 2,7 Two thirds of the PPGSS cases have been associated with acute parvovirus B19 infection, 8 the rest being linked to other viruses. 3 In contrast to EI, patients with PPGSS are considered infectious when presenting with the rash.…”