1989
DOI: 10.1001/archderm.125.9.1249
|View full text |Cite
|
Sign up to set email alerts
|

Papular protothecosis of the chest. Immunologic evaluation and treatment with a combination of oral tetracycline and topical amphotericin B

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
11
0

Year Published

1992
1992
2012
2012

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(11 citation statements)
references
References 0 publications
0
11
0
Order By: Relevance
“…Of all the immunosuppressive drugs prescribed, glucocorticoids are the most widely used and the most specifically associated with the onset of Prototheca infection. Infection has resulted, e.g., from locally injected steroids (66,80,109), systemic steroids (78,109,152), oral steroids (12), and even the application of topical steroid cream (45). Infection has also resulted in diseases that are themselves treated with steroids, e.g., lupus erythematosus (147), lymphoma (53), rheumatoid arthritis (27,100), and myasthenia gravis (92).…”
Section: Epidemiologymentioning
confidence: 99%
See 2 more Smart Citations
“…Of all the immunosuppressive drugs prescribed, glucocorticoids are the most widely used and the most specifically associated with the onset of Prototheca infection. Infection has resulted, e.g., from locally injected steroids (66,80,109), systemic steroids (78,109,152), oral steroids (12), and even the application of topical steroid cream (45). Infection has also resulted in diseases that are themselves treated with steroids, e.g., lupus erythematosus (147), lymphoma (53), rheumatoid arthritis (27,100), and myasthenia gravis (92).…”
Section: Epidemiologymentioning
confidence: 99%
“…Synergistic activation of amphotericin B and tetracycline has been observed in vitro (79). Five patients with cutaneous protothecosis received this combination and were successfully treated (52,61,152,157,166). Takaki et al (144) reported induction of secondary resistance during a 3-year period of therapy and clinical failure.…”
Section: Susceptibility Profilesmentioning
confidence: 99%
See 1 more Smart Citation
“…Temporary improvement by potassium iodide had been documented, but it was later suggested that the lesion might have shown spontaneous regression (13,26). Systemic amphotericin B therapy with or without tetracycline were reported effective in mid 1970's (29,52,53). In 1980's, cases successfully treated with ketoconazole were presented (23,44).…”
Section: Treatment Of Protothecosismentioning
confidence: 99%
“…Defects in neutrophil function and the disability to kill P. wickerhamii are believed to play an important role in the host defense against protothecal infection [5,6]. A role for impaired NK cell activity in protothecosis pathogenicity has been proposed as well [7]. The patient described in our case had no known immunity disorder and immunological analyses did not reveal any abnormalities in the innate nor in the adaptive immune system except from the transient lymphopenia at diagnosis.…”
Section: Discussionmentioning
confidence: 64%