Papillomavirus common antigens. Papillomavirus antigen in verruca, benign papillomatous lesions, trichilemmoma, and bowenoid papulosis: an immunoperoxidase study

Penneys, Neal S.

doi:10.1001/archderm.120.7.859

Cited by 15 publications

(9 citation statements)

References 7 publications

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“…Initial studies involving immunoperoxidase staining did not reveal any such evidence. 26 However, more recent investigations using the polymerase chain reaction (PCR) to detect viral DNA have given mixed results. In 1990, Leonardi and co-workers were unable to detect HPV DNA in 25 cases of trichilemmoma using primerdirected DNA amplification with PCR.…”

mentioning

confidence: 99%

Detection of Human Papillomavirus infection in trichilemmomas and verrucae using in situ hybridization

et al. 2009

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confidence: 99%

Detection of Human Papillomavirus infection in trichilemmomas and verrucae using in situ hybridization

et al. 2009

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“…Some previous studies didn’t detect any evidence for papillomavirus infection applying immunoperoxidase HPV techniques,[16] in situ hybridization for HPV 1, 2, low and high risk genital HPV types,[15] and PCR. [17]…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

et al. 2014

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Background:Papillomatosis is a known histopathologic pattern usually seen in human papillomavirus (HPV) infection and verruca vulgaris is the typical example. This pattern is also detected in some other benign cutaneous lesions such as nevus sebaceous (NS), seborrheic keratosis (SK), trichilemmoma (TL) and inverted follicular keratosis (IFK). The association between papillomatous lesions and HPV infection is questionable.Objective:The objective of this study was to investigate the presence of HPV deoxyribonucleic acid (DNA) in non-genital benign papillomatous skin lesions (NS, SK, TL and IFK) by polymerase chain reaction (PCR).Materials and Methods:A total of 100 specimens of non-genital NS, SK, TL and IFK were retrieved from archives of Dermatopathology Department of Razi Hospital, between 2003 and 2010. The conventional PCR using consensus GP5+/GP6+ primer and hydroxymethylbilane synthase gene as inner control was performed.Results:PCR for HPV DNA revealed no positive results in any of 28 seborrheic keratosis (SK), 28 nevus sebaceous (NS), 28 inverted follicular keratosis (IFK) and 13 trichilemmoma (TL) studied specimens.Conclusion:Papillomatosis is usually a characteristic pattern of HPV infection. However, we found no association between HPV infection and non-genital benign papillomatous lesions.

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“…45,46 Because of the morphological resemblance of trichilemmomas to old warts, manifested by the verrucous surface and the wedge-shaped hypergranulosis, the possibility of HPV as a major factor in the pathogenesis of these lesions was raised by Ackerman in 1978. 36 The data so far, however, are contradictory, mainly resulting from methodological problems with immunohistochemistry 38,39,46,47 and polymerase chain reactions (PCRs). 48,49 In 1977, the association of multiple trichilemmomas and Cowden's syndrome became apparent.…”

Section: Discussionmentioning

confidence: 99%

“…38,39,[46][47][48][49] Not only did electron microscopy failed support a HPV-related etiology 38 but also immunohistochemical results were not in support of it either. 39,46,47 The difficulties with immunohistochemical detection of HPV proteins relate to the plethora of different HPV genotypes that one may fail to detect with known antibodies. Thus, a negative immunohistochemical result does not preclude the presence of another HPV genotype, the antigenic epitopes of which may not be detected by the type-specific antibodies employed.…”

Section: Discussionmentioning

confidence: 99%

p16 Expression in Conventional and Desmoplastic Trichilemmomas

Hilliard

Wakefield²,

Krahl³

et al. 2009

The American Journal of Dermatopathology

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The expression of p16 in cutaneous neoplasms is upregulated in melanocytic neoplasms, ultraviolet radiation-induced neoplasms, such as actinic keratoses and squamous cell carcinomas, and in lesions related to human papillomavirus, such as Bowen's disease and bowenoid papulosis. In cervical dysplasia and tonsillar carcinoma, there is such a close relationship between p16 and human papillomavirus (HPV) to the extent that p16 immunostaining is used as a surrogate marker for the presence of HPV proteins. In this study we were interested in the expression pattern of p16 in trichilemmomas. Twenty-six conventional and 19 desmoplastic trichilemmomas were immunohistochemically stained for p16. p16 immunostaining was noted in the majority of conventional (80.8%) and desmoplastic trichilemmomas (73.7%). The staining pattern was both nuclear and cytoplasmic. The staining intensity was more pronounced in the desmoplastic variant. We describe for the first time p16 expression in trichilemmomas and discuss our findings in conjunction with p16 expression found in other cutaneous neoplasms. Additionally, the relationship of p16 to HPV infection is critically evaluated.

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Papillomavirus common antigens. Papillomavirus antigen in verruca, benign papillomatous lesions, trichilemmoma, and bowenoid papulosis: an immunoperoxidase study

Cited by 15 publications

References 7 publications

Detection of Human Papillomavirus infection in trichilemmomas and verrucae using in situ hybridization

Detection of Human Papillomavirus infection in trichilemmomas and verrucae using in situ hybridization

Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

p16 Expression in Conventional and Desmoplastic Trichilemmomas

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