Papillomatosis of the Bladder and Ureters, Preceded by Condyloma Acuminata of the Vulva: A Case Report

Squamous papilloma of the urinary tract is unrelated to condyloma acuminata

“…Slides were subsequently incubated with an antidigoxigenin antibody linked to alkaline phosphatase (BoehringerMannheim Biochemicals, Indianapolis, IN) and developed in nitroblue tetrazolium and 5-bromo-chloro-3-indolylphosphate. Positive controls consisted of formalin fixed, paraffin embedded sections of cases from other organs, such as the cervix, known to be infected with HPV 6,11,16,18, and 31, 33, 51. Negative control consisted of substituting another cDNA probe (adenovirus) for the HPV probe.…”

Virusinfektionen der ableitenden Harnwege

“…Teilweise war aufgrund des ausgeprägten Befundes unter kurativer Zielsetzung eine Zystektomie (24), in einem Falle zusätzlich Vulvektomie, partiale Vaginektomie, Hysterektomie und bilaterale Salpingo-Oophorektomie notwendig (27). Bei weniger ausgeprägten Fällen wird über eine vollständige Heilung nach transurethraler Elektroresektion und Koagulation berichtet (42).…”

“…Die Diagnose erfolgt mittels Urethro-Zystoskopie und histologischer Untersuchung des Resektats. Die in der Literatur am häufigsten erwähnte Therapie von intravesikalen und urethralen Condylomata acuminata ist die Resektion, wobei teilweise eine vollständige Zystektomie notwendig war (11,24,27,42).…”

Presence and physical state of HPV DNA in prostate and urinary‐tract tissues

“…It is hypothesized that disruption of the circular viral DNA upon integration alters the expression of HPV oncogenic products encoded by E6 and E7 genes, allowing for their specific interaction with important cellregulatory proteins, such as the product of the retinoblastomatumor-suppressor gene (RB) and the p53 protein, also having tumor-suppressor properties. Indeed, it was recently shown that RB and p53 Iegulatory functions are nullified in human cervical-cancer cell lines, presumably as a consequence of their interaction with HPV E6 and E7 oncoproteins (Scheffner et al, 1991).The association of HPV with the urinary tract has not been studied as extensively as with the genital tract, in spite of the fact that since 1962 it was known that condylomata acuminata may also involve the bladder (Kleiman and Lancaster, 1962; Lewis et al, 1962), and may even occur in areas adjacent to the external genitalia, such as the urethra (Bissada et al, 1074; DeBenedictis et a/., Del Mistro et al, 1987;Hotchkiss and Rouse, 1968; Pompeius and Ekroth, 1976). The presence of HPV was shown in lesions of the urethral mucosa (Levine ef al., 1984), in urethral condylomata acuminata (Del Mistro et al., 1087; Murphyet al, 1983), in urine sediments from patients with condylomata, in the meatus urethrae (Melchers et al, 1989) as well as in urethral brushings of males without visible lesions (Zderic et al, 1989).…”

“…The association of HPV with the urinary tract has not been studied as extensively as with the genital tract, in spite of the fact that since 1962 it was known that condylomata acuminata may also involve the bladder (Kleiman and Lancaster, 1962;Lewis et al, 1962), and may even occur in areas adjacent to the external genitalia, such as the urethra (Bissada et al, 1074;DeBenedictis et a/., 1977;Del Mistro et al, 1987;Hotchkiss and Rouse, 1968;Pompeius and Ekroth, 1976). The presence of HPV was shown in lesions of the urethral mucosa (Levine ef al., 1984), in urethral condylomata acuminata (Del Mistro et al, 1087;Murphyet al, 1983), in urine sediments from patients with condylomata, in the meatus urethrae (Melchers et al, 1989) as well as in urethral brushings of males without visible lesions (Zderic et al, 1989).…”