Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors

Yamaki, Vítor Nagai; Solla, Davi Jorge Fontoura; Ribeiro, Renan Ribeiro e; Silva, Saul Almeida da; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha

doi:10.1093/neuros/nyz062

Cited by 20 publications

(20 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PTPR is usually variably reactive for GFAP, synaptophysin, chromogranin, and neural antigens. [ 15 ] In our case, it showed positivity for GFAP and synaptophysin in addition to the classical positivity for PS100, the other markers could not be explored due to their unavailability at the time of diagnosis. Ki67 immunolabeling and mitotic rates vary widely, with a mean of 6%.…”

Section: Discussionmentioning

confidence: 81%

“…The tumors originate from a distinct ependymal cell of the sub-commissural organ with epithelial-like growth patterns and, as described in our patient, fibrovascular papillae with a well-defined secretory function. [ 13 , 15 ] Immunohistochemistry is mandatory for the diagnosis. Staining for S100, NCAM, neuron-specific enolase, and transthyretin is frequent.…”

Section: Discussionmentioning

confidence: 99%

“…Ki67 immunolabeling and mitotic rates vary widely, with a mean of 6%. [ 15 ] No correlation between Ki67 positivity and biological behavior has been proven, but some authors have reported that higher proliferative activity is found in younger patients. Heim et al ., in a series of 21 patients, highlighted an association between increased mitotic/proliferative activity and higher recurrence, but further studies and larger samples are needed to prove the relationship between Ki67, the degree of malignancy, local infiltration, and metastatic activity [ Table 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 , 10 ] First included in the 2007 WHO classification, PTPR is a rare entity that accounts for 0.5–1% of primary central nervous system tumors[ 13 ] and is characterized by a combination of papillary and solid areas with particular immunohistochemical (IHC) features. [ 9 , 15 ] Because of the rarity of PTPR, the treatment of such lesions remains controversial, with the options of surgery, radiotherapy, stereotactic radiosurgery (SRS), or chemotherapy. [ 9 ] We report a case of a PTPR successfully managed with biopsy and complementary SRS and review the literature analyzing the effects of SRS on PTPR.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Papillary tumor of the pineal region: Is stereotactic radiosurgery efficient for this rare entity?

Bechri¹,

Oudrhiri²,

Louraoui

et al. 2021

Surgical Neurology International

View full text Add to dashboard Cite

Background: Papillary tumors of the pineal region are rare neuroepithelial lesions that were described for the 1st time in the WHO 2007 classification. Management of such lesions remains controversial. Case Description: We describe the case of a 26-year-old female who presented with intracranial hypertension syndrome secondary to a 1.9 cm3 lesion of the pineal region causing hydrocephalus. The patient benefited from an endoscopic third ventriculocisternostomy and a biopsy of her lesion in favor of a papillary tumor of the pineal region. After discussion of the surgical risks, the patient refused the surgical option and a stereotactic radiosurgery (SRS) was performed. She improved both clinically (allowing her to regain autonomy) and radiologically (reduction of 60% of tumor volume) at 1 year follow-up. Conclusion: Because of the rarity of the lesion, literature is yet not able to find consensus concerning management of such lesion, but SRS has proven efficiency for these Grades II or III lesions with high recurrence rates. Therefore, it should be considered as a primary therapeutic option allowing good outcome with low risks for the patient.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Papillary tumor of the pineal region: Is stereotactic radiosurgery efficient for this rare entity?

Bechri¹,

Oudrhiri²,

Louraoui

et al. 2021

Surgical Neurology International

View full text Add to dashboard Cite

show abstract

“…After adjustment for age, tumor size and surgical treatment were associated with survival. However, no significant benefits from GTR or adjuvant treatments including radiotherapy were reported ( 58 ).…”

Section: Pineal Region Tumors (Prts)mentioning

confidence: 99%

Rare Primary Central Nervous System Tumors in Adults: An Overview

et al. 2020

View full text Add to dashboard Cite

Overall, tumors of primary central nervous system (CNS) are quite common in adults with an incidence rate close to 30 new cases/100,000 inhabitants per year. Significant clinical and biological advances have been accomplished in the most common adult primary CNS tumors (i.e., diffuse gliomas). However, most CNS tumor subtypes are rare with an incidence rate below the threshold defining rare disease of 6.0 new cases/100,000 inhabitants per year. Close to 150 entities of primary CNS tumors have now been identified by the novel integrated histomolecular classification published by the World Health Organization (WHO) and its updates by the c-IMPACT NOW consortium (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy). While these entities can be better classified into smaller groups either by their histomolecular features and/or by their location, assessing their treatment by clinical trials and improving the survival of patients remain challenging. Despite these tumors are rare, research, and advances remain slower compared to diffuse gliomas for instance. In some cases (i.e., ependymoma, medulloblastoma) the understanding is high because single or few driver mutations have been defined. The European Union has launched European Reference Networks (ERNs) dedicated to support advances on the clinical side of rare diseases including rare cancers. The ERN for rare solid adult tumors is termed EURACAN. Within EURACAN, Domain 10 brings together the European patient advocacy groups (ePAGs) and physicians dedicated to improving outcomes in rare primary CNS tumors and also aims at supporting research, care and teaching in the field. In this review, we discuss the relevant biological and clinical characteristics, clinical management of patients, and research directions for the following types of rare primary CNS tumors: medulloblastoma, pineal region tumors, glioneuronal and rare glial tumors, ependymal tumors, grade III meningioma and mesenchymal tumors, primary central nervous system lymphoma, germ cell tumors, spinal cord tumors and rare pituitary tumors.

show abstract

Chemotherapy

Aldea¹,

Olteanu²

2020

Pineal Region Lesions

View full text Add to dashboard Cite

Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors

Cited by 20 publications

References 76 publications

Papillary tumor of the pineal region: Is stereotactic radiosurgery efficient for this rare entity?

Papillary tumor of the pineal region: Is stereotactic radiosurgery efficient for this rare entity?

Rare Primary Central Nervous System Tumors in Adults: An Overview

Chemotherapy

Contact Info

Product

Resources

About