2017
DOI: 10.1021/acs.analchem.7b02876 View full text |Buy / Rent full text
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Abstract: Cellulose paper is an ideal diagnostic platform for low-cost, easily disposable and lightweight implementation, but requires surface modification to achieve detection with high sensitivity and specificity in complex media. In this work, a polymer-catechol conjugate containing a superhydrophilic nonfouling poly(carboxylbetaine) (pCB) and four surface-binding l-3,4-dihydroxyphenylalanine (DOPA) groups, pCB-(DOPA), were applied onto a paper-based sensor surface via a simple "graft-to" immersion process to render … Show more

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“…Enzymes have been widely used in both electrochemical and optical sensors. However, most enzyme‐based sensors are insufficient to resist protein adsorption in complex biological media, significantly compromising their detection sensitivity …”
Section: Introductionmentioning
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“…Enzymes have been widely used in both electrochemical and optical sensors. However, most enzyme‐based sensors are insufficient to resist protein adsorption in complex biological media, significantly compromising their detection sensitivity …”
Section: Introductionmentioning
“…The equal and opposite charges present on zwitterionic molecule electrostatically attract water molecules, forming a robust hydration layer that repels nonspecific protein adsorption [19]. Previous work has coated hydrophobic surfaces such as poly-(dimethyl siloxane) (PDMS) and polypropylene (PP) with poly-carboxybetaine (pCB) chains using graft-from approach via ARGET-ATRP [16] (Figure 1a), as well as graft-to approaches via DOPA [16], [17], [20] (Figure 1b) and random copolymerization of CB and hydrophobic monomers (Figure 1c). These coated surfaces repelled non-specific protein adsorption and platelet adhesion efficiently even in complex media, including 100% plasma [18].…”
Section: Introductionmentioning
“…These coated surfaces repelled non-specific protein adsorption and platelet adhesion efficiently even in complex media, including 100% plasma [18]. Although pCB has shown excellent in vitro performances in multiple studies, [15][16][17][18]20] several challenges exist for extending this to artificial lung applications. First, artificial lungs' gas exchange membrane surfaces are densely packed and complex in surface geometry.…”
Section: Introductionmentioning
“…CPs have attracted intensive interest in the development of biosensors because they are excellent materials for immobilization of biomolecules and rapid electron transfer for the fabrication of efficient biosensors [29,[304][305][306][307]. Various biomolecule targets with specific properties determined the parameters of CPs based biosensors, such as sensitivity, selectivity, especially response time, which is of crucial importance [308].…”
Section: Biosensorsmentioning