Pancreatic Insulinoma: Case Report of Rare Tumor

Alobaydun, Murtadha A; Albayat, Ali H; Al-Nasif, Anwer A; Habeeb, Ali A; Almousa, Abdulrahman M

doi:10.7759/cureus.6408

Cited by 3 publications

(6 citation statements)

References 5 publications

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“…Laboratory workup for our patient excluded MEN syndrome. A suitable diagnostic test for insulinoma is a 72-hour supervised fasting test showing inappropriate elevation of insulin (≥6 μU/mL) and C-peptide (≥0.2 nmol/L or >0.6ng/ml) levels in the presence of hypoglycemia (<54mg/dl ) [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Insulinoma Mimicking Psychiatric Illness: A Covert Endocrine Tumor

Aslam¹,

Siddiqi²,

Shafiq³

et al. 2023

Cureus

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Insulinomas are rare neuroendocrine tumors with an annual incidence of four cases per million people in the general population. They have varied presentations making their diagnosis a challenging task necessitating a thorough patient assessment to ascertain early detection of this clinical entity by treating physicians. Insulinomas are characterized by the presence of Whipple's triad comprising of hypoglycemic symptoms, biochemical demonstration of hypoglycemia, and improvement of those symptoms after glucose administration. Biochemical detection of insulinoma by supervised 72-hour fasting test with plasma glucose, insulin, C-peptide, and proinsulin level measurements remains the gold standard of diagnosis. In this report, we present an interesting case of delayed diagnosis of pancreatic insulinoma. He was treated for more than six years as a psychiatric illness before receiving the correct diagnosis and treatment. Herein, a middle-aged man with a history of recurrent episodes of altered talk and confusion that resolved after eating something sweet. Biochemical investigations were suggestive of endogenous hyperinsulinemia. Pancreatic insulinoma was localized by a computed tomography scan. The patient underwent surgical resection of the tumor with complete resolution of his symptoms.

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Section: Discussionmentioning

confidence: 99%

“…Insulinomas are typically located within the pancreas; however, extra-pancreatic insulinomas have been recognized. Insulinomas present with neuroglycopenic symptoms that may or may not be accompanied by autonomic symptoms [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Insulinoma Mimicking Psychiatric Illness: A Covert Endocrine Tumor

Aslam¹,

Siddiqi²,

Shafiq³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Once the biochemical diagnosis of insulinoma has been established, imaging studies are performed, including non-invasive and invasive studies such as abdominal and intraoperative ultrasound, endosonography, arteriography, CT-scan and MRI to determine the anatomical location of the tumor and the subsequent surgical plan. The choice of these modalities depends on availability and local radiological skills [11].…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemia In Non-Diabetic Patient: Report of Two Cases of Insulinoma

Rosa¹,

Jiménez-Arcia²,

Pérez-Calvo³

et al. 2022

Arch Metabolic Synd

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Background: Insulinoma is a B-cell tumor of the islets of the pancreas with an incidence of 4 per 1 million people per year, which produces excess insulin and can cause symptoms related to hypoglycemia at the level of the central nervous system or symptoms related to excess release of catecholamines. The presence of hypoglycemia, elevated insulin, proinsulin, and c-peptide levels suggest endogenous hyperinsulinism, which together with imaging findings suggestive of neuroendocrine tumor, allow establishing the diagnostic impression of Insulinoma. Case Report: Patients with neuroglycopenic symptoms, biochemical profile of hypoglycemia, endogenous hyperinsulinemia and radiological finding compatible with insulinoma are reported, who were treated by surgical resection of the tumor, with complete resolution of the initial symptoms. Conclusion: The clinical presentation, diagnosis and treatment of insulinoma represents a clinical challenge, since it is a rare pathology and the delay in diagnosis can have catastrophic consequences for the patient such as permanent brain damage and death.

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“…The benign Brenner generally presents as a small, solid, and well-circumscribed nodule measuring less than 2 cm, however, few cases involving larger sizes have also been reported. The asymptomatic presentation of benign Brenner often leads to their incidental detection [ 1 , 3 ]. Therefore, the definitive diagnosis relies upon histopathological examination as the imaging studies typically yield inconclusive results [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The asymptomatic presentation of benign Brenner often leads to their incidental detection [ 1 , 3 ]. Therefore, the definitive diagnosis relies upon histopathological examination as the imaging studies typically yield inconclusive results [ 3 ]. It presents histologically as nests of transitional cells in a fibrous stroma.…”

Section: Introductionmentioning

confidence: 99%

An Incidental Finding of Low-Grade Appendiceal Mucinous Neoplasm in a Case of Borderline Brenner Tumor of the Ovary

Agarwal,

Chander R

2024

Cureus

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The concurrent presentation of a low-grade appendiceal mucinous neoplasm (LAMN) and a borderline Brenner tumor (BT) of the ovary are exceedingly rare. Brenner tumors stand out as a particularly uncommon form, making up only around 5% of all benign epithelial tumors of the ovary. Among the ovarian Brenner, the borderline subtype is even rarer. Appendiceal neoplasm (LAMN) and right ovarian BT cannot be distinguished due to their anatomical position. LAMN is often an incidental finding and at later stages when left undiagnosed may lead to pseudomyxoma peritonei (PMP). This case describes a postmenopausal woman in her 50s experiencing abdominal pain and bloating for a week. Elevated carcinoembryonic antigen (CEA) levels and imaging suggested a potential right ovarian tumor. Interestingly, it revealed a unique combination of borderline Brenner tumor of the right ovary and low-grade appendiceal mucinous neoplasm.

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Pancreatic Insulinoma: Case Report of Rare Tumor

Cited by 3 publications

References 5 publications

Insulinoma Mimicking Psychiatric Illness: A Covert Endocrine Tumor

Insulinoma Mimicking Psychiatric Illness: A Covert Endocrine Tumor

Hypoglycemia In Non-Diabetic Patient: Report of Two Cases of Insulinoma

An Incidental Finding of Low-Grade Appendiceal Mucinous Neoplasm in a Case of Borderline Brenner Tumor of the Ovary

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