Pancreatic enzyme replacement therapy for people with cystic fibrosis

European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence‐based recommendations

“…41 In patients with CF, improvement in nutritional status has often been demonstrated to be a primary outcome parameter. 113 Long-term studies on PERT demonstrated clinically relevant and statistically significant improvements in nutritional parameters, including body weight and PEI-related symptoms, after 6-12 months. 88,[114][115][116] Some patients may experience symptoms of maldigestion with PERT, but there is a significant improvement in diarrhea, steatorrhea, weight loss, recurrent pain, and the overall QoL.…”

European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence‐based recommendations

“…41 In patients with CF, improvement in nutritional status has often been demonstrated to be a primary outcome parameter. 113 Long-term studies on PERT demonstrated clinically relevant and statistically significant improvements in nutritional parameters, including body weight and PEI-related symptoms, after 6-12 months. 88,[114][115][116] Some patients may experience symptoms of maldigestion with PERT, but there is a significant improvement in diarrhea, steatorrhea, weight loss, recurrent pain, and the overall QoL.…”

High Incidence and Impact of Suspected Exocrine Pancreatic Insufficiency in Patients Post‐Hematopoietic Stem Cell Transplantation: A Single‐Center Prospective Observational Study

“…While additional diagnostic tests could confirm diagnosis, they are not universally available and have limitations [ 4 , 5 , 17 ]. In contrast, PERT is well‐tolerated, readily accessible, and backed by strong evidence for its efficacy [ 33 , 34 , 35 ]. Early intervention with PERT is critical as EPI‐associated complications—such as weight loss, and increased hospitalization duration—pose serious risks, especially in young children, and contribute to increased healthcare costs and reduced quality of life.…”

Clinical Disorders in Cystic Fibrosis That Affect Emergency Procedures—A Case Report and Review

“…Physiotherapy is a critical component in the management of CF, including airway clearance methods such as airway clearance techniques [ 91 , 92 ]. The integration of physiotherapy with pharmacological treatments, such as inhaled antibiotics and CFTR modulators, is essential for delivering comprehensive CF care [ 90 , 93 , 94 ]. Emerging gene therapy approaches, while still under investigation, hold significant promise for long-term treatment by targeting and correcting the underlying genetic mutations responsible for CF [ 90 ].…”

European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence‐based recommendations

“…41 In patients with CF, improvement in nutritional status has often been demonstrated to be a primary outcome parameter. 113 Long-term studies on PERT demonstrated clinically relevant and statistically significant improvements in nutritional parameters, including body weight and PEI-related symptoms, after 6-12 months. 88,[114][115][116] Some patients may experience symptoms of maldigestion with PERT, but there is a significant improvement in diarrhea, steatorrhea, weight loss, recurrent pain, and the overall QoL.…”

High Incidence and Impact of Suspected Exocrine Pancreatic Insufficiency in Patients Post‐Hematopoietic Stem Cell Transplantation: A Single‐Center Prospective Observational Study

“…While additional diagnostic tests could confirm diagnosis, they are not universally available and have limitations [ 4 , 5 , 17 ]. In contrast, PERT is well‐tolerated, readily accessible, and backed by strong evidence for its efficacy [ 33 , 34 , 35 ]. Early intervention with PERT is critical as EPI‐associated complications—such as weight loss, and increased hospitalization duration—pose serious risks, especially in young children, and contribute to increased healthcare costs and reduced quality of life.…”

Clinical Disorders in Cystic Fibrosis That Affect Emergency Procedures—A Case Report and Review

“…Physiotherapy is a critical component in the management of CF, including airway clearance methods such as airway clearance techniques [ 91 , 92 ]. The integration of physiotherapy with pharmacological treatments, such as inhaled antibiotics and CFTR modulators, is essential for delivering comprehensive CF care [ 90 , 93 , 94 ]. Emerging gene therapy approaches, while still under investigation, hold significant promise for long-term treatment by targeting and correcting the underlying genetic mutations responsible for CF [ 90 ].…”

European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence‐based recommendations

“…41 In patients with CF, improvement in nutritional status has often been demonstrated to be a primary outcome parameter. 113 Long-term studies on PERT demonstrated clinically relevant and statistically significant improvements in nutritional parameters, including body weight and PEI-related symptoms, after 6-12 months. 88,[114][115][116] Some patients may experience symptoms of maldigestion with PERT, but there is a significant improvement in diarrhea, steatorrhea, weight loss, recurrent pain, and the overall QoL.…”

High Incidence and Impact of Suspected Exocrine Pancreatic Insufficiency in Patients Post‐Hematopoietic Stem Cell Transplantation: A Single‐Center Prospective Observational Study

“…While additional diagnostic tests could confirm diagnosis, they are not universally available and have limitations [ 4 , 5 , 17 ]. In contrast, PERT is well‐tolerated, readily accessible, and backed by strong evidence for its efficacy [ 33 , 34 , 35 ]. Early intervention with PERT is critical as EPI‐associated complications—such as weight loss, and increased hospitalization duration—pose serious risks, especially in young children, and contribute to increased healthcare costs and reduced quality of life.…”

Clinical Disorders in Cystic Fibrosis That Affect Emergency Procedures—A Case Report and Review

“…Physiotherapy is a critical component in the management of CF, including airway clearance methods such as airway clearance techniques [ 91 , 92 ]. The integration of physiotherapy with pharmacological treatments, such as inhaled antibiotics and CFTR modulators, is essential for delivering comprehensive CF care [ 90 , 93 , 94 ]. Emerging gene therapy approaches, while still under investigation, hold significant promise for long-term treatment by targeting and correcting the underlying genetic mutations responsible for CF [ 90 ].…”