Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils

Audrito, Valentina

doi:10.1007/s11302-021-09782-x

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Similarly, suppression was also subsequently reversed upon the introduction of Anti-PD-1 antibody [90]. Importantly, PDAC liver metastases systematically attract neutrophils that lack P2RX1, leading to the development of an immunosuppressive microenvironment in PDAC liver metastases through the involvement of PD-L1/PD-1 [91]. NET is no exception, NETs in PDAC contain the immunosuppressive ligand PD-L1, which exerts an exhausting and dysfunctional effect on T cells [92,93].…”

Section: Pd-1pd-l1 On Tansmentioning

confidence: 99%

Tumor-associated neutrophils: potential therapeutic targets in pancreatic cancer immunotherapy

Wu,

Mao,

Jiang

et al. 2023

Preprint

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Pancreatic cancer (PC), a highly malignant tumor of the digestive system with poor therapeutic response and low survival rates. In recent years, immunotherapy have developed rapidly and achieved substantial results in many malignant neoplasms. However, responses to immunotherapy in PC are rare and its immunosuppressive and desmoplastic tumor microenvironment (TME) composes an important impediment to their efficacy in PC. Tumor-associated neutrophils (TANs) play a crucial role in the PC microenvironment, exerting a profound influence on PC immunotherapy through establishing a robust stromal shelter and restraining immune cells to assist PC cells in immune escape, which may subvert the current situation of immunotherapy for PC. The purpose of this review is to offer a thorough summary of the latest progress in comprehending the involvement of TANs in PC desmoplastic and immunosuppressive functions, as well as to emphasize the potential therapeutic consequences of focusing on TANs in the immunotherapy of this destructive ailment. Last but not least, we have provided an outlook for the future of TANs in PC immunotherapy.

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Section: Pd-1pd-l1 On Tansmentioning

confidence: 99%

Tumor-associated neutrophils: potential therapeutic targets in pancreatic cancer immunotherapy

Wu,

Mao,

Jiang

et al. 2023

Preprint

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“…When activated by extracellular ATP, P2RX1 can induce rapid Ca 2+, Na+, K+ influx across the cytoplasmic membrane, and lead to cell activation [ 10 ]. The expression of P2RX1 is abundant on TILs in some tumor types, so P2RX1 may be correlated with the TME [ 11 ]. Wang et al found that activated P2X1R enhances neutrophil chemotaxis through the Rho-kinase signaling pathway (random cell migration) [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma

Zou

Fan

et al. 2022

Aging

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The development of novel treatments for breast invasive carcinoma (BC) has been stagnant. P2RX1, a member of the purinergic receptor family, has been found to have a prognostic impact in several tumors. Therefore, we analyzed the expression pattern of P2RX1 in pan-cancers including BC and its impact on survival and found that the expression level of P2RX1 was lower in BC compared with para-cancerous tissues, and higher P2RX1 expression indicated better prognoses. But real-time quantitative reverse transcription PCR (RT-qPCR) and Western blot detected that the P2RX1 expression in normal mammary epithelial cells was lower than that in tumor cells. Then we comprehensively analyzed the regulatory mechanism and protein-protein interaction network, and found that P2RX1 was significantly positively linked with immune cell infiltration and immune checkpoints.

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Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment

et al. 2022

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Pancreatic cancer immune evasion mechanisms: the immunosuppressive role of P2RX1-negative neutrophils

Cited by 4 publications

References 10 publications

Tumor-associated neutrophils: potential therapeutic targets in pancreatic cancer immunotherapy

Tumor-associated neutrophils: potential therapeutic targets in pancreatic cancer immunotherapy

NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma

Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment

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