Pancreatic acinar cell neoplasia in male Wistar rats following 2 years of gabapentin exposure

Management of cancer pain: 1. Wider implications of orthodox analgesics

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Management of cancer pain: 1. Wider implications of orthodox analgesics

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Gabapentin, an Analgesic Used Against Cancer‐Associated Neuropathic Pain: Effects on Prostate Cancer Progression in anIn VivoRat Model

“…This observation would suggest that GBP could have a selective inhibitory effect on the metastatic process and, conversely, that primary and secondary tumourigeneses could be controlled independently, as discussed earlier. The antimetastatic effects of GBP could be due to VGSC blockage . At the highest dose (16.8 μg/kg) tested, however, GBP significantly increased the number of lung metastases by more than twofold.…”

Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties

“…Several FNs were also present. An α 2 δ agonist of the L-calcium channel ( 230 ) induced pancreatic acinar cell adenomas and acinar cell adenocarcinomas, and Leydig cell adenomas in males and uterine endometrial polyps in females ( 33 ). A direct pharmacological explanation could not be found in relation to this receptor ( 34 ).…”

Management of cancer pain: 1. Wider implications of orthodox analgesics

“……”

Gabapentin, an Analgesic Used Against Cancer‐Associated Neuropathic Pain: Effects on Prostate Cancer Progression in anIn VivoRat Model

“…This observation would suggest that GBP could have a selective inhibitory effect on the metastatic process and, conversely, that primary and secondary tumourigeneses could be controlled independently, as discussed earlier. The antimetastatic effects of GBP could be due to VGSC blockage . At the highest dose (16.8 μg/kg) tested, however, GBP significantly increased the number of lung metastases by more than twofold.…”

Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties

“…Several FNs were also present. An α 2 δ agonist of the L-calcium channel ( 230 ) induced pancreatic acinar cell adenomas and acinar cell adenocarcinomas, and Leydig cell adenomas in males and uterine endometrial polyps in females ( 33 ). A direct pharmacological explanation could not be found in relation to this receptor ( 34 ).…”

Management of cancer pain: 1. Wider implications of orthodox analgesics

“……”

Gabapentin, an Analgesic Used Against Cancer‐Associated Neuropathic Pain: Effects on Prostate Cancer Progression in anIn VivoRat Model

“…This observation would suggest that GBP could have a selective inhibitory effect on the metastatic process and, conversely, that primary and secondary tumourigeneses could be controlled independently, as discussed earlier. The antimetastatic effects of GBP could be due to VGSC blockage . At the highest dose (16.8 μg/kg) tested, however, GBP significantly increased the number of lung metastases by more than twofold.…”

Prediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties

“…Several FNs were also present. An α 2 δ agonist of the L-calcium channel ( 230 ) induced pancreatic acinar cell adenomas and acinar cell adenocarcinomas, and Leydig cell adenomas in males and uterine endometrial polyps in females ( 33 ). A direct pharmacological explanation could not be found in relation to this receptor ( 34 ).…”