Panax ginseng effects on DNA damage, CYP1A1 expression and histopathological changes in testes of rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Lee, Ju Han; Sul, Donggeun; Oh, Eunha; Jung, Woon Won; Hwang, Kwang Woo; Hwang, Tae-Sung; Lee, Keon-Cheol; Won, Nam Hee

doi:10.1016/j.fct.2007.05.019

Cited by 21 publications

(16 citation statements)

References 41 publications

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“…The antioxidant effects of Panax ginseng on oxidative DNA and protein damage have been previously reported (Huong, Murakami, Tohda, Watanabe & Matsumoto, ; Lee, Lee & Kim, ; Siddique, Eddeb, Mantle & Mendelow, ). The protective effect of the saponin fraction or extract of Panax ginseng against DNA damage was attributed to its ability to elevate levels of enzymatic and nonenzymatic antioxidants (Zhang, Wu, Duan & Yang, ), NO release (Gillis, ) or Akt activation through inhibition of mitochondrial cytochrome C release (Min et al., ) and reduction of CYP1A1 mRNA (Lee et al., ) in rat testes.…”

Section: Discussionmentioning

confidence: 99%

Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats

et al. 2016

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Korean red ginseng (KRG) may be a beneficial adjuvant along with ciprofloxacin to ameliorate devastating effects of epididymo-orchitis (EO) on male fertility. This study intends to assay the effects of KRG and ciprofloxacin on sperm quality and spermatogenic cells apoptosis in EO rats. We divided 54 adult rats into nine groups (n = 6 rats per group): control (CO), sham-operated (SH), EO (E); ciprofloxacin (C), EO-ciprofloxacin (EC), KRG (G), EO-KRG (EG), ciprofloxacin-KRG (CG) and EO-ciprofloxacin-KRG (ECG). We administered ciprofloxacin and KRG 48 hr after the Escherichia coli (E. coli) injection for 10 days. Bilateral orchiectomy was performed after one sperm cycle (14 days) following the last treatment with ciprofloxacin and KRG. Total and progressive motility of E, C and EC groups decreased. However, motility is improved in CG and ECG in comparison with these groups. The E group induced negative changes in the architecture of testes tissue and dramatic increase in apoptosis indices. Interestingly, co-administration of ciprofloxacin and KRG has dramatically improved Miller's and Johnsen's scores and decreased the apoptosis indices of animals in the ECG group. Combined treatment of ciprofloxacin and KRG may improve the quality of spermatozoa and attenuated apoptosis indices in the ECG group.

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Section: Discussionmentioning

confidence: 99%

Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats

et al. 2016

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“…Inflammatory characteristics of the testis were analysed by the semi-quantitative method adapted from Zhang et al ( 27 ) , establishing the following scores: 0, no inflammatory characteristic; 1, vascular congestion/necrosis; 2, mononuclear cell infiltrate; 3, tissue degeneration. For the evaluation of spermatogenesis, fifty horizontally sectioned seminiferous tubules per animal were scored from 10 (complete spermatogenesis and organised seminiferous epithelium) to 1 (no cells in a tubular section/tubular sclerosis) using Johnsen's score as described by Lee et al ( 28 ) .…”

Section: Methodsmentioning

confidence: 99%

Grape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assay

et al. 2013

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The aim of the present study was to investigate the effects of long-term grape juice concentrate (GJC) consumption, in two dosages, on the reproductive parameters of cadmium-exposed male rats. The effects of the concentrate on body mass gain, plasma testosterone levels, reproductive organ weights, daily sperm production, sperm morphology, testis histopathological and histomorphometrical parameters, and testicular antioxidant markers were investigated. Wistar rats (n 54) were distributed into six groups: CdCl 2 ; cadmium and grape juice I (1·18 g/kg per d); cadmium and grape juice II (2·36 g/kg per d); grape juice I (1·18 g/kg per d); grape juice II (2·36 g/kg per d); control. A single dose of CdCl 2 (1·2 mg/kg body weight (BW)) was injected intraperitoneally and the grape juice was administered orally for 56 d. The results indicated that cadmium changed all reproductive and antioxidant parameters. At dosage I (1·18 g/kg BW), GJC consumption did not show the effects against cadmium-induced damages. In contrast, at dosage II (2·36 g/kg BW), the GJC improved the gonadosomatic index (P¼ 0·003), serum testosterone levels (P¼0·001), the relative weight of epididymis (P¼ 0·013) and ventral prostate (P¼0·052), the percentage of normal sperm (P¼ 0·001), and histopathological and histomorphometrical parameters. In addition, at this dosage, normalisation of the enzymatic activity of superoxide dismutase (P¼0·001) and of testicular levels of glutathione (P¼0·03) were observed. The parameters of the non-exposed rats did not depict significant alterations. In conclusion, the product was able to act as a protector of reproductive function against cadmium-induced damage. Such a property was expressed in a dose-dependent manner as the more effective dose was dosage II. The GJC acted possibly by antioxidant mechanisms. Key words: Functional foods: Reproduction: CadmiumCadmium is a metal found in nature in low concentrations (1) .However, high levels of the metal can be found in the environment due to the burning of fossil fuels, the manufacture of batteries and the production of pigments and stabilisers (2) . The consequent contamination of soil and water results in the exposure of plants and animals to the metal and its bioaccumulation (3,4) . Moreover, tobacco smoke is another major source of human exposure to cadmium (5) .In the male reproductive system, cadmium is known to impair reproductive physiology and decrease sperm quality (6,7) . In addition, in vitro studies have shown that cadmium can stimulate Sertoli cell apoptosis, leading to the disruption of the blood -testis barrier (8,9) . Endocrine disruption is another consequence of cadmium exposure, caused by Leydig cell apoptosis and decreased serum levels of testosterone, as demonstrated in animal studies (10,11) . Clinical trials haveshown an inverse correlation between high serum levels of cadmium and semen quality, including sperm DNA damage, sperm count, motility and morphology (12 -15) . Oxidative stress is related to cadmium-induced damage, increasing the...

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“…Ginseng has been demonstrated to have a cytoprotective effects against these toxins, in which administration of Panax ginseng extract is reported to significantly reduce the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced pathological and genotoxical damages in rat testes 54 . In addition, treatment of Panax ginseng is found to protect Sertoli cells from the cytotoxic effects of bisphenol A 55 …”

Section: Effects Of Ginseng On Spermatogenesis During Disease Statesmentioning

confidence: 99%

Ginseng and male reproductive function

Leung

Wong

2013

Spermatogenesis

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Ginseng is often referred to as the King of all herbs, and is found to be a promising agent to improve general well-being. Ginseng has also been reputed as an aphrodisiac, and is used to treat sexual dysfunction as well as to enhance sexual behavior in traditional Chinese medical practices. Data from animal studies have shown a positive correlation among ginseng, libido, and copulatory performances, and these effects have been confirmed in case-control studies in human. In addition, ginseng is found to improve the sperm quality and count of healthy individuals as well as patients with treatment-related infertility. These actions are mostly attributed to ginsenosides, the major pharmacological active components of ginseng. This review compiles the current knowledge about the multifaceted effects of ginseng on male reproductive function, and also focuses on its mechanisms of action that may represent novel therapeutic strategies for the treatment of male reproductive diseases or disorders.

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Panax ginseng effects on DNA damage, CYP1A1 expression and histopathological changes in testes of rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Cited by 21 publications

References 41 publications

Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats

Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats

Grape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assay

Ginseng and male reproductive function

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