Palmoplantar pustulosis and gluten sensitivity: a study of serum antibodies against gliadin and tissue transglutaminase, the duodenal mucosa and effects of gluten-free diet

Michaëlsson, G; Kristjánsson, Guðjón; Lundin, Inger Pihl; Hagforsen, Eva

doi:10.1111/j.1365-2133.2006.07725.x

Cited by 55 publications

(70 citation statements)

References 17 publications

(27 reference statements)

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“…The benefit of GFD has been shown to extend to patients who are antigliadin antibody-positive but without clinical and histological markers of celiac disease [13–15]. These findings explain both a common trigger among respondents in this study being gluten and a patient-reported improvement of their psoriasis following a GFD.…”

Section: Discussionmentioning

confidence: 64%

“…Although the popular literature contains many dietary recommendations for psoriasis, the scientific literature is limited, especially among randomized controlled trials (RCT). The strongest scientific evidence exists for weight loss, particularly among obese psoriatic patients [3–10], and for gluten-free diets (GFD), which have been reported to improve psoriasis in a subset of patients with celiac-specific antibodies [11–15]. Moreover, there is an absence of studies describing the effects of popular dietary recommendations and regimens, such as a Paleolithic diet or a vegetarian diet.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Afifi

Danesh

Lee

et al. 2017

Dermatol Ther (Heidelb)

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IntroductionPsoriasis patients demonstrate high interest in the role of diet on their skin condition. However, data are lacking to describe dietary interventions among psoriasis patients and associated outcomes. This study aims to identify common dietary habits, interventions and perceptions among patients with psoriasis, and to examine patient-reported skin outcomes in response to these interventions.MethodsWe administered a 61-question survey to the National Psoriasis Foundation membership asking psoriasis patients about dietary habits, modifications, skin responses, and perceptions.ResultsA total of 1206 psoriasis patients responded to the survey. Compared to age- and sex-matched controls, psoriasis patients consumed significantly less sugar, whole grain fiber, dairy, and calcium (p < 0.001), while consuming more fruits, vegetables, and legumes (p < 0.01). Eighty-six percent of respondents reported use of a dietary modification. The percentage of patients reporting skin improvement was greatest after reducing alcohol (53.8%), gluten (53.4%), nightshades (52.1%), and after adding fish oil/omega-3 (44.6%), vegetables (42.5%), and oral vitamin D (41%). Specific diets with the most patients reporting a favorable skin response were Pagano (72.2%), vegan (70%), and Paleolithic (68.9%). Additionally, 41.8% of psoriasis respondents reported that a motivation for attempting dietary changes was to improve overall health.ConclusionThis national survey is among the first to report the dietary behaviors of patients with psoriasis. The data provided from this large cohort may benefit patients and clinicians as they discuss the role of diet in managing both psoriasis and associated cardiometabolic comorbidities.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-017-0183-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Afifi

Danesh

Lee

et al. 2017

Dermatol Ther (Heidelb)

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show abstract

“…37 Although the lesions may occur in the setting of psoriasis elsewhere, it commonly affects patients lacking lesions elsewhere on the body. Also, there is evidence for an association between PPP and variations of the genes in the interleukin-19 subfamily of cytokines 38 and with gluten sensitivity, 39 the latter of which may on occasion also be associated with psoriasis vulgaris.…”

Section: Palmoplantar Psoriasis Phenotypementioning

confidence: 98%

Palmoplantar psoriasis: A phenotypical and clinical review with introduction of a new quality-of-life assessment tool

Farley

Masrour

McKey

et al. 2009

Journal of the American Academy of Dermatology

123

126

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“…The relationships between PPP and certain clinical features, such as gluten sensitivity, thyroid disease, diabetes mellitus and focal infections (like tonsillitis) have been demonstrated in recent studies [5, 6, 12, 13]. The increased frequency of thyroid disorders varies based on different studies, while the prevalence of thyroid pathologies is about 5% in the general population [3].…”

Section: Discussionmentioning

confidence: 99%

“…Several factors may contribute to this disease, including genetics, tobacco use and autoimmune disorders [3, 4]. Additional studies are necessary to clarify the relationship between PPP and autoimmune disorders, such as thyroid disease, gluten sensitivity and type 2 diabetes mellitus [3, 5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Insulin resistance, diabetes mellitus and thyroid dysfunction in patients with palmoplantar pustulosis: a case-controlled study

Ataş

Gönül

2017

pdia

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IntroductionPalmoplantar pustulosis (PPP) is a chronic pustular inflammatory skin disease; however, its pathogenesis is not well understood. Several factors, such as genetics, tobacco use and autoimmune issues, may contribute to this disease.AimThis research was conducted to investigate the relationships between insulin resistance, thyroid disease and PPP.Material and methodsThirty-three patients with PPP and 27 age- and gender-matched controls were analysed for their smoking histories, thyroid function tests, anti-thyroid peroxidase antibody (anti-TPO) levels, fasting glucose, fasting insulin levels and the homeostatic model assessment (HOMA) index for insulin resistance.ResultsWe found significant differences between the PPP and control groups according to their tobacco use and anti-TPO levels (p = 0.009 and p = 0.009, respectively). The proportion of tobacco use was 90% in the PPP patients and 63% in the controls. Gender and tobacco use were predictive risk factors for PPP in the multivariate analysis (OR = 141.7, p < 0.0001 and OR = 147.6, p = 0.006, respectively). An anti-TPO level > 35 U/ml and the presence of a thyroid abnormality were independent risk factors in the univariate, but not the multivariate analysis (OR = 4.2, p = 0.025 and OR = 5.4, p = 0.004, respectively). A moderate correlation between the gender and anti-TPO level was found (r = 0.361, p = 0.039); however, the fasting glucose, insulin and HOMA index were not significant between the PPP and control groups.ConclusionsFemale gender and smoking were the most important risk factors for PPP; however, the increase in the anti-TPO level may be related to the predominance of females afflicted with this disease. Additional studies are necessary to clarify the relationships between PPP, thyroid disease and diabetes mellitus.

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Palmoplantar pustulosis and gluten sensitivity: a study of serum antibodies against gliadin and tissue transglutaminase, the duodenal mucosa and effects of gluten-free diet

Abstract: Patients with PPP should be screened for antibodies against gliadin and tTG. Those with antibodies can be much improved on a GFD regardless of the degree of mucosal abnormalities.

Cited by 55 publications

References 17 publications

Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey

Palmoplantar psoriasis: A phenotypical and clinical review with introduction of a new quality-of-life assessment tool

Insulin resistance, diabetes mellitus and thyroid dysfunction in patients with palmoplantar pustulosis: a case-controlled study

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