Palmar hyperhidrosis: Evidence of genetic transmission

Ro, Kyung M.; Cantor, Rita M.; Lange, Kenneth; Ahn, Samuel S.

doi:10.1067/mva.2002.119507

Cited by 192 publications

(139 citation statements)

References 31 publications

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“…More than a third (35.18%) of all evaluated patients in this study reported positive family history, which was in agreement with other studies, where it ranged from 30% to 65% (4,7,13).…”

Section: Resultssupporting

confidence: 81%

Videothoracoscopic sympathectomy - a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska Kamenica / Videotorakoskopska simpatektomija – standarna hirurška metoda za lečenje primarne hiperhidroze na Klinici za grudnu hirurgiju u Sremskoj Kamenici

Kuhajda¹,

Milos²,

Đurić³

et al. 2010

Serbian Journal of Dermatology and Venerology

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Primary hyperhidrosis affects approximately 3% of the world's population, particularly young female adults. It is defined as excessive, profuse sweating of the palms, soles, armpits and face. Conservative treament includes diverse modalities, however, surgical treatment has shown the best long-term results. The objective of this study was to assess some disease-specific epidemiological characteristics in a pre-selected group of patients seeking surgical therapy, as well as outcomes of thoracoscopic sympathectomy. The severity and impact of hypehidrosis was assessed, using Hyperhidrosis Disease Severity Scale (HDSS: patients rate the serverity of symptoms on a scale from 1 to 4). Thoracoscopic sympathectomy was performed using a double lumen endotracheal tube, via bilateral 5 mm dual port videothoracoscopic camera 0°, and an endoscopic ultrasound activated harmonic scalpel. The sympathetic chain was resected on both sides at the level of the second and the third thoracic ganglion (T2 and T3), using an ultrasound knife. The extirpated chain was also at the level T3-T4 and sent for ex tempore analysis. There were 162 patients undergoing thoracoscopic sympathectomy: 39.51% were males and 60.49% females; at presentation their mean age (± SD) was 30.5 (±8.3), range 16 -58 years. Axillary hyperhidrosis occurs later than palmar-axillary-plantar (p<0.05). A total of 35.18% of the evaluated patients were able to name at least one member of their families who also suffered from hyperhidrosis. The most commonly affected area was palmar-axillary-plantar (30.25%). Fifty patients (30.86%) received conservative therapy before surgery. The most commonly used conservative therapy modalities included different kinds of ointments/tinctures (11.73%), botox (8.02%) and iontophoresis (2.47%). Prior to surgery, 91.36% of patients reported severe sweating (HDSS score 3 or 4). The highest mean score was given for a combination of facial-palmar-axillaryplantar hyperhidrosis (3.80±0.24). All surgeries were successfully performed, with no complications, or perioperative morbidity. The mean hospital stay was 1.28±0.68 days long. After surgery, 93.21% of patients reported mild or moderate hyperhidrosis (HDSS score 1 or 2). Compensatory sweating (lower part of the back, and abdomen) was reported by 34.57% of patients after the surgery. All patients had a 6-months long follow-up: a significant improvement in quality of life was reported by 84.56% of patients (Yates corrected c 2 (1) = 228.42; p=0.0000)); due to compensatory sweating, only 4.94% and 1.85% of patients reported bad and very bad quality of life, respectively. In conclusion, nowadays videothoracoscopic sympathectomy is a standard treatment for primary hyperhidrosis with a high success rate. T5, and to lower limbs at T2 and T7. Videothoracoscopic sympathectomy -a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska KamenicaExcessive sweating or hyperhidrosis affects approximately 3% of the world population (1, 2), predominantly young femal...

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“…More than a third (35.18%) of all evaluated patients in this study reported positive family history, which was in agreement with other studies, where it ranged from 30% to 65% (4,7,13).…”

Section: Resultssupporting

confidence: 81%

Videothoracoscopic sympathectomy - a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska Kamenica / Videotorakoskopska simpatektomija – standarna hirurška metoda za lečenje primarne hiperhidroze na Klinici za grudnu hirurgiju u Sremskoj Kamenici

Kuhajda¹,

Milos²,

Đurić³

et al. 2010

Serbian Journal of Dermatology and Venerology

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“…La sudoración térmica se controla por el hipotálamo, mientras que la sudoración emocional está regulada por la corteza cerebral (véase Figura 3) 3,9,11 . La causa de la hiperhidrosis primaria se desconoce, pero parece haber una respuesta hipersensible a los estímulos hipotalámicos producidos y localizados en el córtex cerebral debido a la alta especificidad que suelen condicionar el carácter temprano en la respuesta sudomotora periférica en la hiperhidrosis focal, siendo el análisis genético lo que sugiere que existe un alelo presente en el 5% de la población afectada de hiperhidrosis y que el 25% de las personas con una o dos copias del alelo tendrán hiperhidrosis, mientras que menos del 1% de los personas con dos alelos normales lo tendrán 11,12,13 . En cambio, en la hiperhidrosis generalizada se caracteriza por la sudoración a lo largo de todo el cuerpo sin existir causa subyacente aparente, siendo las posibles etiologías las que la enmarcan en un trastorno de tipo neurológico, endocrino, infeccioso o farmacológico.…”

Section: Fisiopatologíaunclassified

Aproximación al manejo de la hiperhidrosis en el pie

López‐López

Palomo‐López

Ponce

et al. 2013

Rev. Int. Cienc. Podol.

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“…En un 70% o más de los casos se inicia en la niñez y en un 16-20% en la adolescencia, siendo poco frecuente su comienzo en adultos 28,46,62,72 . Tiene un discreto predominio femenino 46 y en un 25-65% de los casos existen otros familiares afectados (variante familiar), de forma que se ha propuesto una herencia con penetrancia variable 68 .…”

Section: Hiperhidrosis Focal Patológicaunclassified

Simpatectomía toracoscópica: una revisión de la literatura

Bejarano¹,

Manrique²

2010

Neurocirugía

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Palmar hyperhidrosis: Evidence of genetic transmission

Cited by 192 publications

References 31 publications

Videothoracoscopic sympathectomy - a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska Kamenica / Videotorakoskopska simpatektomija – standarna hirurška metoda za lečenje primarne hiperhidroze na Klinici za grudnu hirurgiju u Sremskoj Kamenici

Videothoracoscopic sympathectomy - a standard treatment for primary hyperhidrosis at the Clinic of Thoracic Surgery in Sremska Kamenica / Videotorakoskopska simpatektomija – standarna hirurška metoda za lečenje primarne hiperhidroze na Klinici za grudnu hirurgiju u Sremskoj Kamenici

Aproximación al manejo de la hiperhidrosis en el pie

Simpatectomía toracoscópica: una revisión de la literatura

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