Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review

Iqbal, Muhammad Shahid; Kelly, Charles; Kovařík, Josef; Goranov, Bojidar; Shaikh, Ghazia; Morgan, David; Dobrowsky, W.; Paleri, Vinidh

doi:10.1016/j.radonc.2017.12.011

Cited by 35 publications

(38 citation statements)

References 29 publications

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“…There are various radiotherapy regimens for the palliative treatment of head and neck cancer (68). In the lack of evidence to back a particular dose-fractionation regimen, the following aspects of palliative radiotherapy concept should be considered.…”

Section: Resultsmentioning

confidence: 99%

A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study—Part 2 (Radiation Oncology)

et al. 2019

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Background: The Head and Neck Cancer Working Group of Swiss Group for Clinical Cancer Research (SAKK) has investigated the level of consensus (LOC) and discrepancy in everyday practice of diagnosis and treatment in head and neck cancer.Materials and Methods: An online survey was iteratively generated with 10 Swiss university and teaching hospitals. LOC below 50% was defined as no agreement, while higher LOC were arbitrarily categorized as low (51–74%), moderate (75–84%), and high (≥85%).Results: Any LOC was achieved in 62% of topics (n = 60). High, moderate, and low LOC were found in 18, 20, and 23%, respectively. Regarding Head and Neck Surgery, Radiation Oncology, Medical Oncology, and biomarkers, LOC was achieved in 50, 57, 83, and 43%, respectively.Conclusions: Consensus on clinical topics is rather low for surgeons and radiation oncologists. The questions discussed might highlight discrepancies, stimulate standardization of practice, and prioritize topics for future clinical research.

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Section: Resultsmentioning

confidence: 99%

A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study—Part 2 (Radiation Oncology)

et al. 2019

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“…According to studies, palliative radiotherapy is commonly advocated for patients with incurable malignant disease of the head and neck [ 11 , 12 ]. In the current study, 22% of patients received radiotherapy as a palliative monotherapy and 7% with concomitant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…A similar finding has been reported in other HNC patient series evaluated in Finland [ 5 ]. The goal of treatment in these patients is to alleviate the cancer-related devastating symptoms to improve quality of life while minimizing potential side effects, such as mucositis [ 12 ]. Therefore, radiotherapy should be given in the shortest possible time and its benefits should be judiciously pondered against the possible side effects.…”

Section: Discussionmentioning

confidence: 99%

Non-curative treatment of patients with oral tongue squamous-cell carcinoma

Mroueh

Haapaniemi

Saarto

et al. 2019

Eur Arch Otorhinolaryngol

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Purpose Late-stage OTSCC is associated with poor overall survival (OS). Non-curative treatment approach aims to improve quality of life and prolong survival of patients deemed incurable. The purpose of this study was to investigate the used non-curative treatment modalities for OTSSC and patient survival. Methods All patients diagnosed with OTSCC and treated with non-curative intent at the HUS Helsinki University Hospital (Helsinki, Finland) during the 12-year period of 2005–2016 were included. Survival analysis after the non-curative treatment decision was conducted using the Kaplan–Meier method in this population-based study. Results Eighty-two patients were identified. A non-curative treatment decision was made at presentation without any previous treatment in 26 patients (7% of all patients diagnosed with OTSCC during the study period). Palliative radiotherapy was administered to 24% of all patients. The average survival time after the non-curative treatment decision was 3.7 months (median 2 and range 0–26). Conclusions Due to the short mean survival time after decision for treatment with non-curative intent, and the notable symptom burden in this patient population, a prompt initiation of all non-curative measures is warranted.

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“…These treatments will improve the locoregional control of the disease, quality of life, and possibly improve survival 1 . Two recently published review articles summarized the data on palliative radiation, and fraction schemes for head and neck cancers 2,3 …”

Section: Introductionmentioning

confidence: 99%

“…1 Two recently published review articles summarized the data on palliative radiation, and fraction schemes for head and neck cancers. 2,3 This article reviews the available literature use of concurrent chemoradiotherapy or stereotactic body radiation treatment (SBRT)…”

Section: Introductionmentioning

confidence: 99%

Role of concurrent chemoradiotherapy and stereotactic body radiation treatment for palliation of previously untreated head and neck cancers

Thomas

Packianathan

Ahmed

et al. 2020

Precision Radiation Oncology

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Palliative concurrent chemoradiotherapy has not been well evaluated for patients who are not a candidate for definitive treatment. Even though stereotactic radiotherapy has established a role in the re‐irradiation of recurrent head and neck tumors, its role is not established as a possible primary treatment modality for patients who are not eligible for curative treatment. This article reviews the available literature on the role of chemoradiotherapy and stereotactic radiation for palliation of previously untreated head and neck cancers.

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Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review

Cited by 35 publications

References 29 publications

A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study—Part 2 (Radiation Oncology)

A Review of Controversial Issues in the Management of Head and Neck Cancer: A Swiss Multidisciplinary and Multi-Institutional Patterns of Care Study—Part 2 (Radiation Oncology)

Non-curative treatment of patients with oral tongue squamous-cell carcinoma

Role of concurrent chemoradiotherapy and stereotactic body radiation treatment for palliation of previously untreated head and neck cancers

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