Palliation of bone pain in patients with metastatic cancer using strontium-89 (Metastron)

Kan, Michael K.

doi:10.1097/00002820-199508000-00005

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hematological Effects Hematological effects have been observed in several clinical studies in which 89 Sr, one of the shorter-lived radioactive isotopes of strontium, has been used in cancer therapy for the relief of pain by irradiating and destroying tumors that have metastasized to the bone marrow (Baziotis et al 1998;Ben-Josef et al 1995b;Blake et al 1987c;Breen et al 1992;Kan 1995;Lee et al 1996;Piffanelli et al 2001;Sciuto et al 2001). Significant reductions in platelet and white blood cell counts (averaging 70 and 30%, respectively) were seen 3 months after patients were injected with a single therapeutic dose (40 µCi 89 Sr/kg; 1.5 MBq/kg) (Lee et al 1996).…”

Section: Other Routes Of Exposurementioning

confidence: 99%

Immune System Modifications Induced in a Mouse Model of Chronic Exposure to⁹⁰Sr

Synhaeve¹,

Musilli²,

Stéfani³

et al. 2016

Radiation Research

View full text Add to dashboard Cite

Section: Other Routes Of Exposurementioning

confidence: 99%

Immune System Modifications Induced in a Mouse Model of Chronic Exposure to⁹⁰Sr

Synhaeve¹,

Musilli²,

Stéfani³

et al. 2016

Radiation Research

View full text Add to dashboard Cite

“…Additionally, Sr have shown to accelerate bone healing following fractures and further improved bone microarchitecture (Alegre et al, 2012). Several other therapeutic uses of Sr in the medical field have been investigated in the literature including: relieving osteoarthritis (Z. , palliative treatment for metastatic cancer (Kan, 1995)…”

Section: Therapeutic Usesmentioning

confidence: 99%

Antimicrobial potential of strontium against bacteria associated with peri-implantitis

Alshammari¹

View full text Add to dashboard Cite

Dental implants are nowadays a standard treatment to replace missing teeth and restore function and aesthetics. However, biological complications associated with implants, e.g., peri-implant infections, are common and jeopardize the success of treatment. The main aim of this thesis was to explore strontium (Sr) as a possible prevention strategy against peri-implant infections, since Sr has been shown to have antibacterial action and also to promote titanium (Ti) implant osseointegration. In this thesis, a systematic appraisal of the literature about the antimicrobial potential of Sr-functionalized Ti surfaces for oral applications was performed, and was followed by a series of in vitro studies assessing the antimicrobial potential of Sr against micro-organisms associated with peri-implantitis. In Study I, the systematic appraisal of the literature resulted in an initial list of 1081 potentially relevant publications, where from nine publications from in vitro studies met the inclusion criteria. Most of the included studies showed that Sr-functionalized Ti exerted a limited immediate (i.e., 24 h) antimicrobial effect, likely due to a low Sr ion release; a relevant antimicrobial effect and biofilm inhibition potential against Streptococcus aureus was observed at both early and late timepoints, with an adequate Sr ion release. Study II assessed, in vitro, five different concentrations of soluble Sr(OH)2 (100, 10, 1, 0.1, and 0.01 mM) against 6 different mono-species bacteria (Streptococcusmitis, Staphylococcus epidermidis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Escherichia coli, and Fusobacterium nucleatum) in terms of cell growth, minimal inhibitory concentration (MIC), and biofilm viability. In the agar diffusion test, zones of inhibition were only observed for 0.01, 0.1, and 1 mM of Sr(OH)2 against P. gingivalis. Growth inhibition in planktonic cultures was achieved at 10 mM for all species tested. In the biofilm viability assay, 10 and 100 mM Sr(OH)2 showed potent bactericidal effect against S. mitis, S. epidermidis, A. actinomycetemcomitans, E. coli, and P. gingivalis. It was thus concluded that Sr(OH)2 has antimicrobial properties against bacteria associated with peri-implantitis. Study III assessed the in vitro early- and late bacteriostatic and bactericidal effect of Sr-functionalized wafers on bacteria associated with peri-implantitis (E. coli,S. aureus, Streptococcus oralis, Actinomyces naeslundii, Parvimonas micra, P.gingivalis and F. nucleatum) as mono-species after 2 and 24 hours, and as multispecies at day 1, 3, and 6. Sr-functionalized wafers, compared to Ti controls, were associated with statistically significant less viable cells in both mono- and multispecies tests. Number of colony forming units (CFUs) within the biofilm were significantly higher in Ti wafers, compared to Sr-functionalized wafers, for S. aureus at all time-points of evaluation and for E. coli at day 1. Gingipain activity was higher in Ti wafers compared to Sr-functionalized ones, and the qPCR showed that P. gingivalis comprised 15% of the total biofilm on Ti wafers at day 6, while it remained below detection levels at Sr-coated wafers. In Study IV, the impact of Ti surface roughness (turned vs moderately rough) on the antimicrobial effect of Sr on bacterial associated with peri-implantitis (S. oralis, P. micra, A. naeslundii, F. nucleatum, P. gingivalis, S. aureus, and E. coli), grown in different multispecies consortia, was assessed in vitro. Bacterial viability and biofilm formation, and well as, proteolytic activity of P. gingivalis were assessed at day 1, 3, and 6. Sr-functionalized surfaces were associated with statistically significant reduction in number of viable cells compared to nonfunctionalized surface at all times of investigation for all multispecies tested. Higher proteolytic activity of P. gingivalis was found at non-functionalized Ti disks compared to Sr-functionalized ones. Sr-functionalised surfaces were associated with notable growth inhibition of both E. coli and S. aureus, while P. gingivalis remined undetected at all time points of evaluation on all disks. The turned surface had a slightly higher release of Sr ion compared with the moderately rough surface in the first 24 hours, while both surfaces showed a sustained release for up to 15 days. Overall, the data generated with this series of projects indicate Sr surfaces exerts an antimicrobial potential on bacteria associated with peri-implantitis and it is worthwhile to further explore the potential of Sr-functionalized Ti in the prevention of peri-implant infections.

show abstract