Palladium nanoparticles in glycerol: a clear-cut catalyst for one-pot multi-step processes applied in the synthesis of heterocyclic compounds

Abstract

Palladium/TPPTS nanoparticles in glycerol represent a versatile catalyst leading to a large variety of heterocycles through domino/sequential one-pot approaches.

Making Copper(0) Nanoparticles in Glycerol: A Straightforward Synthesis for a Multipurpose Catalyst

“…Pursuing our interest in applying one‐pot multicomponent processes for the synthesis of privileged scaffolds present in natural products and biologically active compounds, we decided to use ortho ‐functionalized benzaldehydes in order to prepare indolizines, benzofurans and quinolines (see Tables S8–S10 in the Supporting Information), by an intramolecular cycloisomerization via the formation of a propargylic amine intermediate (Figure ).…”

Catalysis in glycerol: a survey of recent advances

“…Moreover, it was possible to achieve an outstanding catalytic activity with a solid ligand-free catalyst (a palladium-loaded cross-linked chitosan). Chahdoura et al (2013aChahdoura et al ( , 2014aChahdoura et al ( , 2015 synthesised palladium nanoparticles in neat glycerol under low hydrogen pressure and studied the effects of the presence of stabilisers. The prepared materials were subsequently used in various Pd-catalysed reactions, such as C-C and C-heteroatom bond formation and hydrogenations.…”

Mechanistic study on gold(I)‐catalyzed crosscoupling of diazo compounds: A DFT study

“…Heterocyclic compounds as structural motifs are often found in many organic materials, pharmaceuticals, synthetic intermediates, and natural products . Among them, pyrazoles and their derivatives display rich chemical properties and therefore have widespread applications .…”

“…Our calculated results are in good agreement with the experimental observations. The present study may provide a useful guide for understanding these kinds of gold(I)-catalyzed cross-coupling reactions of diazo compounds.cross-coupling reaction, density functional theory, diazo compounds, reaction mechanism 1 | I N TR ODU C TI ON Heterocyclic compounds as structural motifs are often found in many organic materials, [1][2][3] pharmaceuticals, [4][5][6] synthetic intermediates, [7][8][9] and natural products. [10][11][12][13] Among them, pyrazoles and their derivatives display rich chemical properties and therefore have widespread applications.…”

“…Unclear issues concern the following questions: (1) how does the selective decomposition of diazo compounds/cyclization cascade take place in detail? (2) Which step is the rate-determining step? (3) Why the possible product P2 (Scheme 1)…”