Palladium (II) complexes based on Schiff base ligands derived from ortho-vanillin; synthesis, characterization and cytotoxic studies

Faghih, Zeinab; Neshat, Abdollah; Wojtczak, Andrzej; Faghih, Zahra; Mohammadi, Zahra; Varestan, Solmaz

doi:10.1016/j.ica.2017.11.025

Cited by 37 publications

(15 citation statements)

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“…Schiff bases and their complexes are versatile extensively used for industrial goals and expose a contrasting broad range of biological activities include, antifungal, antibacterial, Anti‐leishmanial, anti‐molluscicidal, antimalarial, anti‐proliferative, anti‐inflammatory, antitumor, anti‐amoebic, antiviral, antioxidant and antipyretic properties. The Schiff base ligands derived from o ‐vanillin connected with Pd atom forming metal complexes showed a cytotoxic effect on three cancer cell lines: breast (MCF‐7), lung (A549) and ovarian (SKOV3) . While Cu (II) complexes of Schiff bases of the pyrrolizine‐5‐carboxamides displayed cytotoxic effect on the breast (MCF‐7), ovary (A2780) and colon (HT29) human adenocarcinoma, in addition to MRC5 (normal human fetal lung fibroblast) cells .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of VO²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Shakdofa

Labib

Abdel‐Hafez³

et al. 2018

Applied Organom Chemis

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Complexes of VO 2+ , Co 2+ , Ni 2+ , Cu 2+ , and Zn 2+ ethyl-6-ethyl-2-((2hydroxybenzylidene)amino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate were synthesized and characterized via different spectroscopic techniques.The whole results declared that the complexes assembled in 1:1 mole ratio furthermore, the spectroscopic data analysis proved the present ligand adhered to the different metal ions in neutral or monobasic tridentate ligand via azomethine nitrogen, carbonyl oxygen atoms and protonated/deprotonated phenolic hydroxyl group. The UV-Vis. and ESR spectroscopic data analysis proposed a distorted octahedral or octahedral structure for all complexes. The ESR spectra for Cu 2+ complexes (5-6) revealed an axial symmetry with g‖ > g ┴ > g e , denoting to distorted octahedral Cu 2+ complex and the free electrons in the M shell exist in a d (x2-y2) orbital with a remarkable covalent bond aspect. The synthesized complexes showed moderate to superb fungicide activity. All complexes are more active than both standard drug and ligand against C. albicans where complexes (5-7) are more active against A. flavus and compounds (1), (4-5), (7) against S. cerevisiae whereas only complex (6) is more active against A niger.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of VO²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Shakdofa

Labib

Abdel‐Hafez³

et al. 2018

Applied Organom Chemis

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“…Following enough convergence, the cells were treated with 25% trypsin–EDTA (Biosera, France) and sub‐cultured. The cells were then washed, counted, and prepared for cytotoxic MTT assay as previously described …”

Section: Resultsmentioning

confidence: 99%

“…The cells were then washed, counted, and prepared for cytotoxic MTT assay as previously described. [26,27]…”

Section: Cell Lines and Cell Culturementioning

confidence: 99%

Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones

Rahmannejadi

Yavari

Khabnadideh

2020

Journal of Heterocyclic Chem

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With the aim of obtaining new antitumor agents, a series of bis‐quinazolin‐4(3H)‐ones (3a‐3 f) were designed and synthesized. These products contain 4‐oxo‐1,2,3,4‐tetrahydro‐quinazoline and 3H‐quinazolin‐4‐one moieties linked together via a propyl chain. Cytotoxic activities of 3a‐3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF‐7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a, 3b, and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF‐7.

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“…Identical stretching vibrations were observed in the FT‐IR spectra of Zn‐2 and Zn‐3 , Figure S2 and Figure S3. It is notable that in the free ligands, C=N bond stretching frequency is observed at frequencies higher than 1610 cm –1 . Sharp signals for methoxy and tert ‐butyl aliphatic C–H stretching vibrations were observed at 2929 cm –1 and 2959 cm –1 in the FT‐IR spectrum of Zn‐2 and Zn‐3 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Alcohol Oxidations by Schiff Base Manganese(III) Complexes

et al. 2020

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Asymmetric Schiff base manganese(III) complexes involving salen ligands, N,N′-bis(salicylidene)2,3-diaminopyridine, N,N′-bis(3-methoxysalicylidene)2,3-diaminopyridine, N,N′bis(3,5-di-tert-butylsalicylidene)2,3-diaminopyridine and N,N′bis(3,5-di-chloro-salicylidene)2,3-diaminopyridine were prepared and their catalytic activity was investigated in the oxidation of some primary and secondary alcohols. During optimization of oxidation reactions, Mn-4, bearing electron withdrawing N,N′-Bis(3,5-di-chloro-salicylidene)2,3-diaminopyridine ligand, showed higher activity than other catalysts tested. The [a]

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Palladium (II) complexes based on Schiff base ligands derived from ortho-vanillin; synthesis, characterization and cytotoxic studies

Cited by 37 publications

References 36 publications

Synthesis and Characterization of VO²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Synthesis and Characterization of VO²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones

Alcohol Oxidations by Schiff Base Manganese(III) Complexes

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Palladium (II) complexes based on Schiff base ligands derived from ortho-vanillin; synthesis, characterization and cytotoxic studies

Cited by 37 publications

References 36 publications

Synthesis and Characterization of VO2+, Co2+, Ni2+, Cu2+ and Zn2+ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Synthesis and Characterization of VO2+, Co2+, Ni2+, Cu2+ and Zn2+ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones

Alcohol Oxidations by Schiff Base Manganese(III) Complexes

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Synthesis and Characterization of VO²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents

Synthesis and Characterization of VO²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents