Pairing off: a bottom‐up approach to the human gut microbiome

Abreu, Clare I.; Lopez, Anthony; Gore, Jeff

doi:10.15252/msb.20188425

Cited by 9 publications

(6 citation statements)

References 11 publications

(19 reference statements)

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“…A ‘bottom-up’ approach, based on analysing pairwise interactions in a synthetic gutmicrobiome community using a generalized Lotka-Voltera model, has been suggested to complement the understanding of the gut microbial ecology and how the vast bacterial communities interact with each other. The use of pairwise interactions may be more appropriate in predicting the ability of specific probiotics to persist in the gut, or to determine the effects of removing a particular species, as opposed to higher order interactions [ 91 , 92 ]. Both synbiotics and multi-strain probiotics have also been proposed to confer longer lasting benefits compared to single-species probiotics often employed in current studies and could be an interesting area of research in the future [ 93 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Revisit gut microbiota and its impact on human health and disease

Ding

Goh

et al. 2019

Journal of Food and Drug Analysis

205

123

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Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, diabetes, cancer, Inflammatory Bowel Disease (IBD), gout, depression and arthritis, as well as infant health and longevity.

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Section: Future Perspectivesmentioning

confidence: 99%

Revisit gut microbiota and its impact on human health and disease

Ding

Goh

et al. 2019

Journal of Food and Drug Analysis

205

123

View full text Add to dashboard Cite

show abstract

“…This challenged the researchers to explore the roles of the human microbiota and their potential applications in managing human health and disease conditions. The large intestine is the predominant location where microbes are present in the human gut and our understanding of the composition, interaction, and functions of these gut microbes [9] continues to develop as a result of advancement in major initiatives that have categorized the microbiome [1,[10][11][12][13]. The human gut microbiome is highly dynamic during the various stages of human development and has been implicated in a variety of health and disease conditions.…”

Section: Introductionmentioning

confidence: 99%

Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review

et al. 2020

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Understanding how dietary nutrients modulate the gut microbiome is of great interest for the development of food products and eating patterns for combatting the global burden of non-communicable diseases. In this narrative review we assess scientific studies published from 2005 to 2019 that evaluated the effect of micro- and macro-nutrients on the composition of the gut microbiome using in vitro and in vivo models, and human clinical trials. The clinical evidence for micronutrients is less clear and generally lacking. However, preclinical evidence suggests that red wine- and tea-derived polyphenols and vitamin D can modulate potentially beneficial bacteria. Current research shows consistent clinical evidence that dietary fibers, including arabinoxylans, galacto-oligosaccharides, inulin, and oligofructose, promote a range of beneficial bacteria and suppress potentially detrimental species. The preclinical evidence suggests that both the quantity and type of fat modulate both beneficial and potentially detrimental microbes, as well as the Firmicutes/Bacteroides ratio in the gut. Clinical and preclinical studies suggest that the type and amount of proteins in the diet has substantial and differential effects on the gut microbiota. Further clinical investigation of the effect of micronutrients and macronutrients on the microbiome and metabolome is warranted, along with understanding how this influences host health.

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“…Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms shown through proteomics 5,6 ), where spatial structure and dynamic host responses can critically affect the microbiota 2,7 .…”

Section: Introductionmentioning

confidence: 99%

Synthetic microbiota reveal priority effects and keystone strains in the Arabidopsis phyllosphere

et al. 2019

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Multicellular organisms including plants are colonised by microorganisms, some of which are beneficial to growth and health. The assembly rules for establishing the plant microbiota are not well understood, and neither is the extent to which their members interact. We conducted drop-out and late introduction experiments by inoculating Arabidopsis thaliana with synthetic communities from a resource of 62 native bacterial strains to test how arrival order shapes community structure. As a read-out we tracked the relative abundance of all strains in the phyllosphere of individual plants. Our results showed that community assembly is historically contingent and subject to priority effects. Missing strains could, to various degrees, invade an already established microbiota, which was itself resistant and remained largely unaffected by latecomers. Additionally, our results indicate that individual Proteobacteria (Sphingomonas, Rhizobium) and Actinobacteria (Microbacterium, Rhodococcus) strains have the greatest potential to affect community structure as keystone species.

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Pairing off: a bottom‐up approach to the human gut microbiome

Cited by 9 publications

References 11 publications

Revisit gut microbiota and its impact on human health and disease

Revisit gut microbiota and its impact on human health and disease

Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review

Synthetic microbiota reveal priority effects and keystone strains in the Arabidopsis phyllosphere

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