Pain management with transdermal drug administration: A review

Hu, Weitong; Bian, Qiong; Zhou, Yanjun; Gao, Jian

doi:10.1016/j.ijpharm.2022.121696

Cited by 10 publications

(4 citation statements)

References 110 publications

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“…Transdermal administration of these drugs may provide a more consistent and predictable delivery than oral administration, which may lead to better pain control and fewer side effects. Lidocaine is a local anesthetic that can be used to relieve pain in a specific area [ 41 ]. Transdermal delivery of lidocaine has been investigated for the treatment of chronic pain conditions such as neuropathic pain and post-herpetic neuralgia.…”

Section: Resultsmentioning

confidence: 99%

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Cammarano,

Dello Iacono,

Meglio

et al. 2023

Pharmaceutics

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Transdermal drug delivery systems have become an intriguing research topic in healthcare technology and one of the most frequently developed pharmaceutical products in the global market. In recent years, researchers and pharmaceutical companies have made significant progress in developing new solutions in the field. This study sheds light on current trends, collaboration patterns, research hotspots, and emerging frontiers of transdermal drug delivery. Herein, a bibliometric and patent analysis of data recovered from Scopus and The Lens databases, respectively, is reported over the last 20 years. From 2000 to 2022, the annual global publications increased from 131 in 2000 to 659 in 2022. Researchers in the United States, China, and India produced the highest number of publications. Likewise, most patent applications have been filed in the USA, China, and Europe. The recovered patents are 7275, grouped into 2997 patent families, of which 314 were granted. This study could support the work of decision-makers, scientific managers, or scientists to create new business opportunities or save money, time, and intellectual capital, thereby defining when a research or technology project should be a priority or not.

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Section: Resultsmentioning

confidence: 99%

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Cammarano,

Dello Iacono,

Meglio

et al. 2023

Pharmaceutics

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“…Despite the recent number of reviews on pain, its mechanism, its comorbidities, and potential therapeutics (Garcia-Larrea and Quesada, 2022;Haanpää and Treede, 2022;Hu et al, 2022;Lorente et al, 2022b;Song et al, 2022), the crosstalk between neuroinflammation, opioids and pain remains poorly understood. Nonetheless, numerous in vivo experiments in rats have shown that morphine administration provokes the release of inflammatory mediators in the dorsal horn of the spinal cord, which is a key area in pain management (Johnston, 2004;Bai et al, 2014;Tsai et al, 2016;Eidson and Murphy, 2019).…”

Section: Pain-derived Neuroinflammation: Role Of Morsmentioning

confidence: 99%

Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

Cuitavi

Torres-Pérez

Lorente

et al. 2023

Neuroscience & Biobehavioral Reviews

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“…Local anesthesia for surgical, postoperative, or peripheral neuropathic pain could dramatically reduce patients’ chronic pains . Lidocaine, one of the most commonly used and effective local anesthetics in clinic practice, is characterized by rapid onset, low risk of anaphylaxis, and moderate duration of action and has been formulated in several dosage forms for the treatment of chronic pain .…”

Section: Introductionmentioning

confidence: 99%

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

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Chronic pain emerges as a major global health issue, significantly impacting individuals' health and quality of life. In this study, we designed a bilayer microneedle loaded with lidocaine nanocomposites in the inner layer and adrenaline (Adr) in the outer layer (HCP MNs) for modulated sequential release to achieve prolonged local anesthesia. The obtained HCP MNs featured an intact structure with adequate mechanical strength for efficient skin penetration. The bilayer structure of MNs was evidenced by loading two fluorescent dyes in each layer. Furthermore, these HCP MNs were capable of inducing rapid as well as prolonged local anesthetic effects in guinea pigs. Hence, the bilayer MN coloaded with Adr and lidocaine nanocomposite serves as a promising transdermal delivery platform for chronic pain management.

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Pain management with transdermal drug administration: A review

Cited by 10 publications

References 110 publications

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Advances in Transdermal Drug Delivery Systems: A Bibliometric and Patent Analysis

Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

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