Pain and tension-type headache: a
review of the possible pathophysiological
mechanisms

Milanov, Ivan; Богданова, Д. С.

doi:10.1007/s10194-004-0061-1

Cited by 10 publications

(3 citation statements)

References 74 publications

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“…Peripheral sensitization would have more localized effects and cannot alone explain the generalized hyperalgesia seen in patients with chronic TTH [54,55]. The expansion of hypersensitivity to other tissues, such as skin, is consistent with referred hyperalgesia, which may be explained by convergence of multiple peripheral sensory afferents onto sensitized spinal cord neurons.…”

Section: Central Pain Sensitivitymentioning

confidence: 90%

The Role of Muscles in Tension-Type Headache

Bendtsen

Fernández-de-la-Peñas

2011

Curr Pain Headache Rep

122

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The tenderness of pericranial myofascial tissues and number of myofascial trigger points are considerably increased in patients with tension-type headache (TTH). Mechanisms responsible for the increased myofascial pain sensitivity have been studied extensively. Peripheral activation or sensitization of myofascial nociceptors could play a role in causing increased pain sensitivity, but firm evidence for a peripheral abnormality still is lacking. Peripheral mechanisms are most likely of major importance in episodic TTH. Sensitization of pain pathways in the central nervous system due to prolonged nociceptive stimuli from pericranial myofascial tissues seem to be responsible for the conversion of episodic to chronic TTH. Treatment directed toward muscular factors include electromyography biofeedback, which has a documented effect in patients with TTH, as well as physiotherapy and muscle relaxation therapy, which are most likely effective. Future studies should aim to identify the source of peripheral nociception.

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Section: Central Pain Sensitivitymentioning

confidence: 90%

The Role of Muscles in Tension-Type Headache

Bendtsen

Fernández-de-la-Peñas

2011

Curr Pain Headache Rep

122

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“…This is mainly due to the paucity of existing targets in its putative pathophysiological cascade [53,54]. In the past, peripheral factors have been considered to be leading factors.…”

Section: Aspirin and Tension-type Headachementioning

confidence: 99%

Aspirin and tension-type headache

Farinelli

Martelletti

2007

J Headache Pain

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Acetylsalicylic acid (ASA, Aspirin) is among the most used drugs worldwide. At present, Aspirin represents a quite versatile drug employed in the control of pain symptomatologies and in situations such as prevention of both ischaemic stroke and cardiovascular events. Aspirin causes inhibition of prostaglandin (PG) synthesis by inactivation of the cyclooxygenase (COX) enzyme. ASA constitutes the focus of new researches explaining more widely Aspirin's control of inflammation. The induction of the endogenous epimers lipoxins (Aspirin-triggered 15-epi-lipoxins, ATLs) represents one of the most recent achievements. This particular feature of Aspirin is not shared by other NSAIDs. ASA is well known as a headache medication, figuring as a possible treatment choice in tension-type headache but also in acute migraine attacks. Furthermore, a new Aspirin formulation with a greater rapidity of action has been introduced. In conclusion, little information exists on the subject and more studies are required.

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“…Pain is a multidimensional experience that arises due to a complex integration of sensory-discriminatory, affective-motivational and cognitive-evaluating processes, which are influenced by variety of biopsychosocial factors. Unlike acute pain, which signals tissue damage, chronic pain does not have a protective function, and it can continue after stopping the effect of the harmful agent [1]. Scientists' research proves that the maladaptive patterns of behavior support chronicity, predicting future disability and impaired psychosocial functioning [2].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Situation During Pain by Patients With Chronic Pain

Telbizova,

Varbanov

2023

JofIMAB

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The way a person perceives and interprets the situation during pain provokes a variety of emotional and behavioral responses. Aim: The aim of the study was to analyze the assessment of the situation during pain by patients with chronic pain. Materials and methods: A sample of 120 patients with chronic pain was studied. Sixty-one of them had clinically manifested symptoms of depression, and fifty-nine had no depression. The patients were evaluated using the following scales: HAM-D-17, Spielberger questionnaire – STAI – form Y1 and form Y2 and VAS. A model of four situations was applied to assess the situation during pain: unique, risky, routine and situation of uncertainty. Results: The mean age of the sample was 51.90±11.94. Women predominate (81.7%) over men (18.3%). The group with depression had moderate severity of depression and pain intensity and high state and trait anxiety. A majority of them (48.4%) assessed the situation during pain as a risk and/or an uncertainty. The group without depression had moderate state and trait anxiety and mild pain intensity. More than half of them (62.7%) assessed the situation as routine. Conclusion: Depression and anxiety affect the perceived situation during pain. Assessing and understanding the specific links between them is essential for forming adaptive ways of coping with chronic pain.

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Pain and tension-type headache: a review of the possible pathophysiological mechanisms

Cited by 10 publications

References 74 publications

The Role of Muscles in Tension-Type Headache

The Role of Muscles in Tension-Type Headache

Aspirin and tension-type headache

Assessment of the Situation During Pain by Patients With Chronic Pain

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