Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB‐induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP‐1 pathway

Abstract

Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects of PS on ultraviolet B (UVB)-induced photoaging. In this study, paeonol (PA) was detected the main compound in PS root. In vitro, PS and PA significantly inhibited UVB-induced phosphorylation of mitogen-activated protein kinase and activator protein 1 in keratinocytes, which consequently led to degradation of procollagen type I. On the other hand, PS and PA increased NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 expression, confirmed by greater nuclear accumulation of nuclear factor E2-releated factor 2 (Nrf2). Furthermore, this study proved that the endogenous antioxidant system Nrf2/antioxidant response element was regulated by dihydrolipoamide dehydrogenase, a tricarboxylic acid (TCA) cycle-associated protein whose level was decreased after UVB exposure. PS and PA promoted the production of dihydrolipoamide dehydrogenase, as well as the activation of Nrf2 and antioxidant response element, resulting in preventing procollagen type I ruined caused by UVB. In vivo, topical application of PS and PA attenuated UVB-induced matrix metalloproteinase-1 production and promoted procollagen type I in hairless mice. These results suggested PA a promising botanical in protecting skin from UVB-induced photoaging.

A Peptide YGDEY from Tilapia Gelatin Hydrolysates Inhibits UVB‐mediated Skin Photoaging by Regulating MMP‐1 and MMP‐9 Expression in HaCaT Cells

“…As an important member in MMPs, MMP‐1 and MMP‐9 co‐degrade collagen, elastin and other structural proteins in ECM , which not only leads to wrinkle formation, sagging skin, but also exacerbate trans epidermal water loss and reduces skin hydration . Type I procollagen is the main structural component of ECM, and MMP‐1 specifically degrades Type I procollagen during photoaging . Loss of structural integrity of ECM is considered to be the main cause of photoinduced skin wrinkling.…”

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes

“…Paeonia suffruticosa is an important Chinese herbal medicine for the treatment of pain and inflammatory disease, including osteoarthritis [6]. Previously, scholars usually focused on its root extracts, such as paeonol or its analogues, as effective pharmaceutical ingredients, but other parts of the herb have not been fully studied [7,8]. Recently, it was found that the seeds of P. suffruticosa are rich in oligostilbenes, including resveratrol and its dimers and trimers [9].…”

Protection of paeonol against epirubicin-induced hepatotoxicity: A metabolomic study

“…EPI-induced hepatocyte oxidative stress and paeonolrelated antioxidants change a series of biochemical parameters, which impact downstream metabolic processes (6,7). Conventional judgment of hepatotoxicity is principally according to the changes of aminopherases, including aspartate transaminase (AST), which increased after hepatonecrosis (8).…”