Paediatric lung transplant outcomes vary with<i>Mycobacterium abscessus</i>complex species: Table 1–

Robinson, Paul D.; Harris, Kathryn; Aurora, Paul; Hartley, John C.; Tsang, Victor; Spencer, Helen

doi:10.1183/09031936.00143512

Cited by 26 publications

(18 citation statements)

References 10 publications

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“…In a case series of five paediatric patients infected with M. abscessus prior to lung transplantation, three patients were infected with M. a. abscessus , one with M. massiliense and one with M. bolletii 332. The patients with M. massiliense and M. bolletii survived long term after transplant.…”

Section: Section 12d: What Antibiotic Regimen Should Be Used To Treatmentioning

confidence: 99%

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

Haworth

Banks

Capstick

et al. 2017

Thorax

588

679

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Section: Section 12d: What Antibiotic Regimen Should Be Used To Treatmentioning

confidence: 99%

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

Haworth

Banks

Capstick

et al. 2017

Thorax

588

679

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“…These rapidly-growing, non-tuberculous mycobacteria cause chronic pulmonary disease, particularly in patients with cystic fibrosis (CF) and other chronic lung diseases. M. abscessus is an important pathogen that has emerged in the CF patient population that has been associated with poor clinical outcomes, especially following lung transplantation [3–5]. This is due, at least in part, to the extensive antibiotic resistance that makes infections with this organism difficult to treat [2,6].…”

Section: Introductionmentioning

confidence: 99%

Cross-transmission is not the source of newMycobacterium abscessusinfections in a multi-centre cohort of cystic fibrosis patients

Doyle

Rubio

Dixon

et al. 2019

Preprint

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BackgroundMycobacterium abscessusis an extensively drug resistant pathogen that causes pulmonary disease particularly in cystic fibrosis (CF) patients. Identifying direct patient-to-patient transmission ofM. abscessusis critically important in directing infection control policy for the management of risk in CF patients. A variety of clinical labs have used molecular epidemiology to investigate transmission. However there is still conflicting evidence as to howM. abscessusis acquired and whether cross-transmission occurs. Recently labs have applied whole-genome sequencing (WGS) to investigate this further and in this study we investigate whether WGS can reliably identify cross-transmission inM. abscessus.MethodsWe retrospectively sequenced the whole genomes of 145M. abscessusisolates from 62 patients seen at four hospitals in two countries over 16 years.ResultsWe have shown that a comparison of a fixed number of core single nucleotide variants (SNVs) alone cannot be used to infer cross-transmission inM. abscessusbut does provide enough information to replace multiple existing molecular assays. We detected one episode of possible direct patient-to-patient transmission in a sibling pair. We found that patients acquired uniqueM. abscessusstrains even after spending considerable time on the same wards with otherM. abscessuspositive patients.ConclusionsThis novel analysis has demonstrated that the majority of patients in this study have not acquiredM. abscessusthrough direct patient-patient transmission or a common reservoir. Tracking transmission using WGS will only realise its full potential with proper environmental screening as well as patient sampling.Key pointsWhole genome sequencing should replace current molecular typing used routinely in clinical microbiology laboratories.Patient-to-patient spread ofM. abscessusis not common.Environmental screening may provide a better understanding acquisition ofM. abscessusinfections.

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“…40% of these positive NTM cultures are caused by Mycobacterium abscessus [1], one of the rapidly growing NTMs present in the environment. Patients with M. abscessus infection are difficult to treat, due to natural and acquired antibiotic resistance [2,3], and an infection with M. abscessus is controversially discussed as a contraindication for lung transplantation [4].…”

Section: Deficient Interleukin-17 Production In Response To Mycobactementioning

confidence: 99%

Deficient interleukin-17 production in response toMycobacterium abscessusin cystic fibrosis

et al. 2016

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Paediatric lung transplant outcomes vary withMycobacterium abscessuscomplex species: Table 1–

Cited by 26 publications

References 10 publications

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

Cross-transmission is not the source of newMycobacterium abscessusinfections in a multi-centre cohort of cystic fibrosis patients

Deficient interleukin-17 production in response toMycobacterium abscessusin cystic fibrosis

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