Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

Brew, Bronwyn K.; Osvald, Emma Caffrey; Gong, Tong; Hedman, Anna M.; Holmberg, K.; Larsson, Henrik; Ludvigsson, Jonas F.; Mubanga, Mwenya; Smew, Awad I.; Almqvist, Catarina

doi:10.1111/cea.14207

Cited by 11 publications

(6 citation statements)

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“…It has also been consistently shown that maternal psychological stress during pregnancy and postpartum is associated with psychological and psychiatric issues in children up to the age of 21 years 6,7 . Finally, children with asthma and allergic disease are more likely to have co‐occurring internalizing disorders (depression and anxiety), and there is some evidence to suggest that a common shared environmental factor may be in part responsible 8–11 . In this study we propose that maternal mental health disorders may be the common shared factor.…”

Section: Introductionmentioning

confidence: 68%

“…6,7 Finally, children with asthma and allergic disease are more likely to have co-occurring internalizing disorders (depression and anxiety), and there is some evidence to suggest that a common shared environmental factor may be in part responsible. [8][9][10][11] In this study we propose that maternal mental health disorders may be the common shared factor. Supporting this theory, a study by Brehm et al found that the association between child psychological stress and asthma was greater in mothers who were stressed in pregnancy, compared to those who were not, 12 and another study found that children treated for depression with mothers who also had depression, were more likely to have asthma compared to children whose mothers did not have depression.…”

Section: Backg Rou N Dmentioning

confidence: 91%

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Maternal mental health disorders and offspring asthma and allergic diseases: The role of child mental health

Brew,

Gong,

Ohlin

et al. 2024

Pediatric Allergy Immunology

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BackgroundMaternal psychological stress during pregnancy and postnatally has been shown to be associated with offspring atopic diseases (asthma, atopic dermatitis and allergic rhinitis). The aim of this study was to assess whether this association may be attributable to the child's own mental health disorders.MethodThe study population included 15,092 twin children born 2002–2010 in Sweden. Questionnaire data at age 9 years was linked to national patient‐ and prescription registers. Maternal mental health during pregnancy and 3 years postnatally were identified from diagnosis and medication data (depression, anxiety and stress disorders). Atopic diseases in children were identified from questionnaires, diagnosis and medication data. Child mental health status (depression and anxiety) was identified from questionnaires. Three‐way decomposition methods tested for mediation or interaction by child mental health disorders.ResultsMaternal mental health disorders were associated with most child atopic diseases including asthma aRR1.36 (95% CI 1.12, 1.60), and child mental health disorders, aRR1.73 (95% CI 1.56, 1.92). Children with mental health disorders were comorbid for atopic diseases with only asthma reaching statistical significance, aRR1.29 (95% CI 1.14, 1.47). Three‐way decomposition found that mediation or interaction by child mental health disorders did not account for the mother mental health and child atopy associations except in parent‐report asthma, where child mental health disorders mediated 13.4% (95% CI 2.1, 24.7) of the effect, but not for objectively defined (diagnosis and medication) asthma.ConclusionThe associations between maternal mental health and child asthma and allergic diseases do not appear to be attributable to child mental health disorders.

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Section: Introductionmentioning

confidence: 68%

Section: Backg Rou N Dmentioning

confidence: 91%

Maternal mental health disorders and offspring asthma and allergic diseases: The role of child mental health

Brew,

Gong,

Ohlin

et al. 2024

Pediatric Allergy Immunology

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“…Firstly, asthma, anxiety, and depression are heterogeneous, with correlations influenced by various factors like gender and age; for example, females with severe asthma often tend to have higher rates of anxiety and depression than males ( 47 ). Additionally, the bidirectional relationship between depression, anxiety, and asthma not only exists in adults but also extends to children with asthma ( 48 ). Our understanding is still limited, which necessitates future studies with larger sample sizes to conduct more detailed subgroup analysis of these diseases.…”

Section: Discussionmentioning

confidence: 99%

Genetic analyses of the bidirectional associations between common mental disorders and asthma

Yan,

Chen,

Guo

et al. 2024

Front. Psychiatry

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ObjectiveAlthough extensive research has explored the link between mental disorders and asthma, the characteristics and patterns of this association are still unclear. Our study aims to examine the genetic causal links between common mental disorders (specifically, anxiety and depression) and asthma.MethodsWe conducted genetic analyses including linkage disequilibrium score regression (LDSC) and bidirectional two-sample Mendelian randomization (MR) analyses, and utilized summary statistics from recent large-scale Genome-Wide Association Studies (GWASs) in European populations, covering sensation of anxiety or depression, anxiety sensation, depression sensation, anxiety disorders, major depression disorder (MDD), and asthma.ResultsLDSC revealed significant genetic correlations among sensation of anxiety or depression, MDD and asthma (P < 0.017), highlighting potential genetic correlation between anxiety disorders and asthma (P < 0.05 yet > 0.017). In bidirectional two-sample MR, inverse-variance weighted (IVW) analyses suggested that genetic liability to asthma was significantly associated with an increased risk of sensation of anxiety or depression (OR = 4.760, 95%CI: 1.645–13.777), and MDD (OR = 1.658, 95%CI: 1.477–1.860). Conversely, IVW analyses indicated that genetic liability to anxiety disorders was not associated with an increased risk of asthma (P > 0.01), nor was genetic liability to asthma associated with an increased risk of anxiety disorders (P > 0.01). Furthermore, no significant genetic causal relationships were observed for other studied traits. Multivariate MR, after adjusting for body mass index and alcohol consumption, further corroborated the independent causal effect of genetic predisposition to MDD on the risk of asthma (OR = 1.460, 95% CI: 1.285–1.660).ConclusionOur study establishes MDD as a predisposing factor for asthma. Meanwhile, anxiety disorders are not causal risk factors for asthma, nor is the reverse true. It is recommended to closely monitor asthma symptoms in patients with MDD.

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“…The mean Asthma Control Test score (ACT) was 17 ± 5, mean mini-Asthma Quality of Life Questionnaire score (mini-AQLQ) was 4.23 ± 1.15, and median exacerbation rate the past 1 year was 3 (1-5). All patients had at least 1 treatable trait and a median of four traits (3)(4)(5)(6). The prevalence of pulmonary, extrapulmonary and behavioural traits was 86.5%, 85.7% and 57.9%, respectively.…”

Section: R S E a R C H L E T T E R Treatable Traits In An Asian Diffi...mentioning

confidence: 99%

Treatable traits in an Asian difficult asthma cohort

Saripalli,

Sieow,

Chan

et al. 2024

Clin Experimental Allergy

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Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 145 publications

Maternal mental health disorders and offspring asthma and allergic diseases: The role of child mental health

Maternal mental health disorders and offspring asthma and allergic diseases: The role of child mental health

Genetic analyses of the bidirectional associations between common mental disorders and asthma

Treatable traits in an Asian difficult asthma cohort

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