Padrão de remodelação e função ventricular em ratos expostos à fumaça do cigarro

Azevedo, Paula Schmidt; Minicucci, Marcos F.; Matsubara, Beatriz Bojikian; Matsubara, Luiz Shiguero; Duarte, Delfim; Paiva, Sérgio Alberto Rupp de; Zornoff, Leonardo A. M.

doi:10.1590/s0066-782x2010005000004

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…In addition, the echocardiographic findings obtained in this study (SMs vs. the C) were in accordance with previous reports related to cardiac structural manifestations of smoking (increased wall thickness and/or cardiac mass) in animal models (42). …”

Section: Discussionsupporting

confidence: 93%

Daily assessment of arterial distensibility in a pediatric population before and after smoking cessation

Bassareo¹,

Fanos²,

Crisafulli³

et al. 2014

Clinics

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OBJECTIVES:Cigarette smoking is an important modifiable cardiovascular risk factor associated with increased stiffness of the large arteries in adulthood. This study aimed to 1) evaluate arterial distensibility and echocardiographic measures in adolescent smokers before and after participation in a successful smoking cessation program and to 2) compare the findings obtained with data from a control population of healthy non-smokers.METHODS:A total of 31 young smoking subjects (58.1% male; range: 11-18 years old; mean: 16.5±1.4 years old; mean tobacco consumption: 2.6±0.6 years) were examined before commencing and after taking part for at least 1 year in a smoking cessation program (mean: 1.4±0.3 years). Arterial stiffness was measured using the previously validated QKd100-60 method. Twenty-four-hour ambulatory blood pressure monitoring and transthoracic echocardiography were also performed.RESULTS:(Smokers before abuse cessation vs. smokers after abuse cessation) systolic blood pressure: p<0.004; diastolic blood pressure: p<0.02; mean blood pressure: p<0.01; QKd100-60 value: 183±5 vs. 196±3 msec, p<0.009; p = ns for all echocardiographic parameters. (Smokers after abuse cessation vs. controls) systolic blood pressure: p<0.01; diastolic blood pressure: p<0.03; mean blood pressure: p<0.02; QKd100-60 value: 196±3 vs. 203±2 msec, p<0.04; p<0.02, p<0.01, and p<0.05 for the interventricular septum, posterior wall, and left ventricular mass, respectively.CONCLUSIONS:Despite successful participation in a smoking cessation program, arterial distensibility improved but did not normalize. This finding underlines the presence of the harmful effect of arterial rigidity in these individuals, despite their having quit smoking and their young ages, thus resulting in the subsequent need for a lengthy follow-up period.

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Section: Discussionsupporting

confidence: 93%

Daily assessment of arterial distensibility in a pediatric population before and after smoking cessation

Bassareo¹,

Fanos²,

Crisafulli³

et al. 2014

Clinics

View full text Add to dashboard Cite

show abstract

“…Considering the consequences of the remodeling process, previous studies have shown that animals exposed to TS presented different remodeling patterns, including hypertrophy, dilation, hypokinesis and dysfunction. 3 , 21 , 26 - 29 The present data showed that TS changed the cardiac morphology, as evidenced by the higher left atrium area and myocytes hypertrophy. In addition, TS lowered the +dp/dt, a parameter of cardiac systolic function under controlled conditions.…”

Section: Discussionsupporting

confidence: 56%

Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure

Minicucci

Oliveira

Santos

et al. 2016

Arquivos Brasileiros De Cardiologia

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BackgroundTobacco smoke exposure is an important risk factor for cardiac remodeling. Under this condition, inflammation, oxidative stress, energy metabolism abnormalities, apoptosis, and hypertrophy are present. Pentoxifylline has anti‑inflammatory, anti-apoptotic, anti-thrombotic and anti-proliferative properties.ObjectiveThe present study tested the hypothesis that pentoxifylline would attenuate cardiac remodeling induced by smoking.MethodsWistar rats were distributed in four groups: Control (C), Pentoxifylline (PX), Tobacco Smoke (TS), and PX-TS. After two months, echocardiography, invasive blood pressure measurement, biochemical, and histological studies were performed. The groups were compared by two-way ANOVA with a significance level of 5%.ResultsTS increased left atrium diameter and area, which was attenuated by PX. In the isolated heart study, TS lowered the positive derivate (+dp/dt), and this was attenuated by PX. The antioxidants enzyme superoxide dismutase and glutathione peroxidase were decreased in the TS group; PX recovered these activities. TS increased lactate dehydrogenase (LDH) and decreased 3-hydroxyacyl Coenzyme A dehydrogenases (OH-DHA) and citrate synthase (CS). PX attenuated LDH, 3-OH-DHA and CS alterations in TS-PX group. TS increased IL-10, ICAM-1, and caspase-3. PX did not influence these variables.ConclusionTS induced cardiac remodeling, associated with increased inflammation, oxidative stress, apoptosis, and changed energy metabolism. PX attenuated cardiac remodeling by reducing oxidative stress and improving cardiac bioenergetics, but did not act upon cardiac cytokines and apoptosis.

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“…The combined exposure group showed an joined effect of the two environmental risk factors on the most frequently studied lung abnormalities (airway wall thickening, end-terminal airspace dilation and inflammatory infiltrate), followed by the group exposed to inhaled cigarette smoke and nasal instillation of a suspension of particulate matter from fossil fuels, thereby enhancing the combined effect of both types of exposure. In an experimental model used to study cardiac alterations triggered by smoking, Azevedo et al 51 developed a controlled model of mice exposure to cigarette smoke for two months. At the end of the period, the exposed group showed higher incidences of concentric and eccentric myocardial hypertrophy shown at the echocardiography.…”

Section: Experimental Studiesmentioning

confidence: 99%

Tabagismo: o que tem sido abordado em periódicos brasileiros

Prado¹,

Lombardi²,

Miethke-Morais³

et al. 2012

Arq. Bras. Cardiol.

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Padrão de remodelação e função ventricular em ratos expostos à fumaça do cigarro

Abstract: Background: The relevance of the remodeling pattern in the model of rats exposed to cigarette smoke is not known.

Cited by 14 publications

References 27 publications

Daily assessment of arterial distensibility in a pediatric population before and after smoking cessation

Daily assessment of arterial distensibility in a pediatric population before and after smoking cessation

Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure

Tabagismo: o que tem sido abordado em periódicos brasileiros

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