Padma 28 for intermittent claudication

Abstract

Some evidence exists from individual trials to suggest that Padma 28 may be effective in increasing walking distances, at least in the short term (four months), in people with IC. Side effects do not appear to be a problem. However, the longer term effects of treatment are unknown and the clinical significance of the improvements in walking distance are questionable. Moreover, the quality of the evidence is limited by the small sample size of the available trials, limited reporting of statistical analyses that compared treatment groups, and relatively high withdrawal rates that were linked to the outcome. That is, patients were withdrawn if they failed to improve walking distance. There was also evidence of publication bias. We therefore feel there is currently insufficient evidence to draw conclusions regards the effectiveness of Padma 28 in the routine management of IC. Further well-designed research would be required to determine the true effects of this herbal preparation.

Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis

“…As stated before, we also found a slight rise of ICD in placebo-treated controls; several studies reported in other reviews 33,69 show a slight increment in patients treated with placebo, which refers to improvement in the lifestyle or in the physical activities of the patients when assessed for confounders; 27,70 this was particularly evident when the placebo group went through supervised and personalized physical activity programmes 26,71 or the optimization of concomitant treatments.…”

Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis

“…As stated before, we also found a slight rise of ICD in placebo-treated controls; several studies reported in other reviews 33,69 show a slight increment in patients treated with placebo, which refers to improvement in the lifestyle or in the physical activities of the patients when assessed for confounders; 27,70 this was particularly evident when the placebo group went through supervised and personalized physical activity programmes 26,71 or the optimization of concomitant treatments.…”

Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives

“…Padma 28, based on the well-known 28th formula of a traditional Tibetan formula collection, is a Swiss herbal remedy that consists of over 22 herbal drugs. It has been reported that Padma 28 could improve circulatory disorders such as intermittent claudication in clinical trials ( Stewart et al, 2016 ). A systematic review interpreted that indications of efficacy were also found in other vascular diseases, inflammatory conditions and lipid metabolism disturbances ( Vennos et al, 2013 ), which suggested that Padma 28 may have the ability to repair metabolic and immune functions.…”

How to refine your approach to peripheral arterial disease

“…Padma 28, a Tibetan herbal formulation, appears to improve maximal walking distance with adverse effect rates similar to placebo. 34 Other supplements, including vitamin E, ginkgo biloba, and omega-3 fatty acids, have no evidence of benefit. [35][36][37] When revascularization is needed Patients who develop limb ischemia or lifestylelimiting claudication despite conservative therapy are candidates for revascularization.…”

Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis

“…As stated before, we also found a slight rise of ICD in placebo-treated controls; several studies reported in other reviews 33,69 show a slight increment in patients treated with placebo, which refers to improvement in the lifestyle or in the physical activities of the patients when assessed for confounders; 27,70 this was particularly evident when the placebo group went through supervised and personalized physical activity programmes 26,71 or the optimization of concomitant treatments.…”

Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives

“…Padma 28, based on the well-known 28th formula of a traditional Tibetan formula collection, is a Swiss herbal remedy that consists of over 22 herbal drugs. It has been reported that Padma 28 could improve circulatory disorders such as intermittent claudication in clinical trials ( Stewart et al, 2016 ). A systematic review interpreted that indications of efficacy were also found in other vascular diseases, inflammatory conditions and lipid metabolism disturbances ( Vennos et al, 2013 ), which suggested that Padma 28 may have the ability to repair metabolic and immune functions.…”

How to refine your approach to peripheral arterial disease

“…Padma 28, a Tibetan herbal formulation, appears to improve maximal walking distance with adverse effect rates similar to placebo. 34 Other supplements, including vitamin E, ginkgo biloba, and omega-3 fatty acids, have no evidence of benefit. [35][36][37] When revascularization is needed Patients who develop limb ischemia or lifestylelimiting claudication despite conservative therapy are candidates for revascularization.…”

Sulodexide improves pain-free walking distance in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis

“…As stated before, we also found a slight rise of ICD in placebo-treated controls; several studies reported in other reviews 33,69 show a slight increment in patients treated with placebo, which refers to improvement in the lifestyle or in the physical activities of the patients when assessed for confounders; 27,70 this was particularly evident when the placebo group went through supervised and personalized physical activity programmes 26,71 or the optimization of concomitant treatments.…”

Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives

“…Padma 28, based on the well-known 28th formula of a traditional Tibetan formula collection, is a Swiss herbal remedy that consists of over 22 herbal drugs. It has been reported that Padma 28 could improve circulatory disorders such as intermittent claudication in clinical trials ( Stewart et al, 2016 ). A systematic review interpreted that indications of efficacy were also found in other vascular diseases, inflammatory conditions and lipid metabolism disturbances ( Vennos et al, 2013 ), which suggested that Padma 28 may have the ability to repair metabolic and immune functions.…”

How to refine your approach to peripheral arterial disease

“…Padma 28, a Tibetan herbal formulation, appears to improve maximal walking distance with adverse effect rates similar to placebo. 34 Other supplements, including vitamin E, ginkgo biloba, and omega-3 fatty acids, have no evidence of benefit. [35][36][37] When revascularization is needed Patients who develop limb ischemia or lifestylelimiting claudication despite conservative therapy are candidates for revascularization.…”