Paclitaxel-loaded pH responsive hydrogel based on self-assembled peptides for tumor targeting

Raza, Faisal; Zhu, Ying; Chen, Li; You, Xinru; Zhang, Jiayuan; Khan, Asifullah; Khan, Muhammad Waseem; Hasnat, Muhammad; Zafar, Hajra; Wu, Jun; Ge, Liang

doi:10.1039/c9bm00139e

Cited by 140 publications

(91 citation statements)

References 58 publications

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“…Tumor cells exhibit lots of characteristic features due to the disordered metabolic profile compared to the normal cells (Mura et al, 2013), such as weak acidity, high specific enzyme and over-expressed proteins (Wang et al, 2003;Zhang et al, 2018;Raza et al, 2019). For example, the poor oxygen perfusion in most kinds of tumor cells causes the elevated levels of lactic acid, resulting in weakly acidic extracellular and intracellular tumor microenvironments (Wojtkowiak et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(b-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled release to enhance the cancer treatment efficacy. The NP with pH-sensitivity and targeting effect was successfully prepared by validation of charge reversal and increase of hydrodynamic diameter after each deposition of functional layer. We further showed the DOX-loaded NP had higher drug loading capacity, suitable particle size, spherical morphology, good uniformity, and high serum stability for drug delivery. We confirmed that the drug release profile was triggered by low pH with sustained release manner in vitro. Confocal microscopy research demonstrated that the NP was able to effectively target and deliver DOX into human non-small cell lung carcinoma (A549) cells in comparison to free DOX. Moreover, the blank NP showed negligible cytotoxicity, and the DOX-loaded NP could efficiently induce the apoptosis of A549 cells as well as free DOX. Notably, in vivo experiment results showed that the DOX-loaded NPs effectively inhibited the growth of tumor, enhanced the survival of tumor-bearing mice and improved the therapeutic efficacy with reduced side-effect comparing with free drug. Therefore, the NP could be a potential intelligent anticancer drug delivery carrier for cancer chemotherapy, and the LbL method might be a useful strategy to prepare multi-functional platform for drug delivery.

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Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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“…The acidic pH environment of the tumor triggered the DOX release from the pH-responsive hydrogel, leading to enhanced tumor inhibition. [132]…”

Section: Ph-responsive Injectable Hydrogels For Controlled and Local mentioning

confidence: 99%

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Rizzo

Kehr

2020

Adv Healthcare Materials

199

152

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Injectable hydrogels have received considerable interest in the biomedical field due to their potential applications in minimally invasive local drug delivery, more precise implantation, and site‐specific drug delivery into poorly reachable tissue sites and into interface tissues, where wound healing takes a long time. Injectable hydrogels, such as in situ forming and/or shear‐thinning hydrogels, can be generated using chemically and/or physically crosslinked hydrogels. Yet, for controlled and local drug delivery applications, the ideal injectable hydrogel should be able to provide controlled and sustained release of drug molecules to the target site when needed and should limit nonspecific drug molecule distribution in healthy tissues. Thus, such hydrogels should sense the environmental changes that arise in disease states and be able to release the optimal amount of drug over the necessary time period to the target region. To address this, researchers have designed stimuli‐responsive injectable hydrogels. Stimuli‐responsive hydrogels change their shape or volume when they sense environmental stimuli, e.g., pH, temperature, light, electrical signals, or enzymatic changes, and deliver an optimal concentration of drugs to the target site without affecting healthy tissues.

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“…59 Chemotherapy is one of the three widely accepted conventional methods for tumour treatment that obtain anti-tumour effects by killing tumour cells using cytotoxic drugs. 60 However, due to the poor selectivity, chemotherapy may cause a certain degree of toxic effects on the immune system. The traditional concept holds that there is an antagonistic effect between chemotherapy and immunotherapy, and these two treatment methods are difficult to use together.…”

Section: Combination Treatment Of Pd-1/pd-l1 Inhibitors and Chemotherapymentioning

confidence: 99%

Development of cancer immunotherapy based on PD-1/PD-L1 pathway blockade

2019

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Paclitaxel-loaded pH responsive hydrogel based on self-assembled peptides for tumor targeting

Abstract: Intratumoral delivery of chemotherapeutic agents may permit the localization of drugs in tumors, decrease nonspecific targeting and increase efficacy.

Cited by 140 publications

References 58 publications

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery

Development of cancer immunotherapy based on PD-1/PD-L1 pathway blockade

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