2012
DOI: 10.18632/aging.100515
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Abstract: P73 is a member of the p53 transcription factors family with a prominent role in neurobiology, affecting brain development as well as controlling neuronal survival. Accordingly, p73 has been identified as key player in many age-related neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and Niemann-Pick type C disease. Here we investigate possible correlations of p73 with Parkinson disease. Tyrosine hydroxylase is a crucial player in Parkinson disease being the enzyme necessary for dopamine synt… Show more

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Cited by 14 publications
(9 citation statements)
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References 88 publications
(96 reference statements)
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“…aging, [27][28][29] and metabolism 27 through the regulation of gene [30][31][32] and microRNA expression. Mice deficient in p73 display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus.…”
Section: Introductionmentioning
confidence: 99%
“…aging, [27][28][29] and metabolism 27 through the regulation of gene [30][31][32] and microRNA expression. Mice deficient in p73 display neuronal pathologies, including hydrocephalus and hippocampal dysgenesis, with defects in the CA1-CA3 pyramidal cell layers and the dentate gyrus.…”
Section: Introductionmentioning
confidence: 99%
“…Soon after, the study reported the ability for p73 to regulate tyrosine hydroxylase and, by doing this, to protect against events that can lead to Parkinson disease. 75 Following this line, it would be important to study the link between individiual DNp73 and Parkinson disease.…”
Section: Dnp73 and Chemosensitivitymentioning
confidence: 99%
“…30 In both cases p53 status is a relevant factor. Although abnormal protein variants were described several decades ago, [31][32][33][34] only recently has a distinct promoter been identified, 35 codifying of the full-length p53 or Δ0p53 (promoter 1) or for the Δ33p53 and Δ60p53 (promoter 2), similar to what occurs in other members of the p53 family, namely p73 36 and p63. 37 This results in significant changes in its functional properties as a transcription factor.…”
Section: Introductionmentioning
confidence: 99%