P7. Intra-operative margin detection using Cerenkov Luminescence Imaging during radical prostatectomy – Initial results from the PRIME study

Michel, Constance; Freeman, Alex; Jameson, Charles; Waddington, W; Tuch, David S.; Harboe, Morten; Cathcart, P.

doi:10.1016/j.ejso.2015.08.112

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Still, precise patient dosage will be determined in our on-going clinical feasibility study. Prior studies with 18 F showed that the radiation dose to the surgeon due to the CLI procedure was 34 μSv per procedure and 2–20 μSv per scrub nurse [14, 16]. The use of 68 Ga-PSMA decreases the injected dose and thus improves the radiation safety for both the patient and personnel.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, CLI has the advantage of using clinically approved imaging agents, which facilitates fast clinical translation of the technology. Academic researchers worldwide have already demonstrated the (pre-)clinical feasibility of CLI for intraoperative specimen analysis [8, 14–16]. The first clinical trial for margin assessment with CLI, performed in breast cancer surgery with 18 Fluorine-Fluorodeoxyglucose ( 18 F-FDG), has shown promising initial results [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F

et al. 2019

View full text Add to dashboard Cite

BackgroundCerenkov Luminescence Imaging (CLI) is an emerging technology for intraoperative margin assessment. Previous research only evaluated radionuclide 18-Fluorine (18F); however, for future applications in prostate cancer, 68-Gallium (68Ga) seems more suitable, given its higher positron energy. Theoretical calculations predict that 68Ga should offer a higher signal-to-noise ratio than 18F; this is the first experimental confirmation. The aim of this study is to investigate the technical performance of CLI by comparing 68Ga to 18F.ResultsThe linearity of the system, detection limit, spatial resolution, and uniformity were determined with the LightPath imaging system. All experiments were conducted with clinically relevant activity levels in vitro, using dedicated phantoms. For both radionuclides, a linear relationship between the activity concentration and detected light yield was observed (R2 = 0.99). 68Ga showed approximately 22 times more detectable Cerenkov signal compared to 18F. The detectable activity concentration after a 120 s exposure time and 2 × 2 binning of 18F was 23.7 kBq/mL and 1.2 kBq/mL for 68Ga. The spatial resolution was 1.31 mm for 18F and 1.40 mm for 68Ga. The coefficient of variance of the uniformity phantom was 0.07 for the central field of view.Conclusion68Ga was superior over 18F in terms of light yield and minimal detection limit. However, as could be expected, the resolution was 0.1 mm less for 68Ga. Given the clinical constraints of an acquisition time less than 120 s and a spatial resolution < 2 mm, CLI for intraoperative margin assessment using 68Ga could be feasible.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Patients undergoing a therapeutic radical prostatectomy receive a 370 MBq intravenous injection of 18 F-Choline, and the margins of the resected prostatectomy specimen are imaged using the investigational intraoperative CLI camera. The initial results show that intraoperative 18 F-Choline CLI is a feasible and low-risk procedure [ 57 ]. Elevated radiances were present in all three primary tumours (tumour-to-background ratio between 2.49 and 4.90), and CLI imaging did not add additional time to surgery.…”

Section: Applications Of CLI For Image-guided Surgery and Ongoing Climentioning

confidence: 99%

Cerenkov luminescence imaging (CLI) for image-guided cancer surgery

Grootendorst

Cariati

Kothari

et al. 2016

Clin Transl Imaging

View full text Add to dashboard Cite

Cerenkov luminescence imaging (CLI) is a novel molecular optical imaging technique based on the detection of optical Cerenkov photons emitted by positron emission tomography (PET) imaging agents. The ability to use clinically approved tumour-targeted tracers in combination with small-sized imaging equipment makes CLI a particularly interesting technique for image-guided cancer surgery. The past few years have witnessed a rapid increase in proof-of-concept preclinical studies in this field, and several clinical trials are currently underway. This article provides an overview of the basic principles of Cerenkov radiation and outlines the challenges of CLI-guided surgery for clinical use. The preclinical and clinical trial literature is examined including applications focussed on imageguided lymph node detection and Cerenkov luminescence endoscopy, and the ongoing clinical studies and technological developments are highlighted. By intraoperatively guiding the oncosurgeon towards more accurate and complete resections, CLI has the potential to transform current surgical practice, and improve oncological and cosmetic outcomes for patients.

show abstract

Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging

Boykoff,

Grimm

2024

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

P7. Intra-operative margin detection using Cerenkov Luminescence Imaging during radical prostatectomy – Initial results from the PRIME study

Cited by 5 publications

References 0 publications

Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F

Performance evaluation of Cerenkov luminescence imaging: a comparison of 68Ga with 18F

Cerenkov luminescence imaging (CLI) for image-guided cancer surgery

Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging

Contact Info

Product

Resources

About