2016
DOI: 10.18632/aging.100898 View full text |Buy / Rent full text
|
|

Abstract: The role of p53 family member, p63 in oncogenesis is the subject of controversy. Limited research has been done on the clinical implications of p63 expression in diffuse large B-cell lymphoma (DLBCL). In this study, we assessed p63 expression in de novo DLBCL samples (n=795) by immunohistochemistry with a pan-p63-monoclonal antibody and correlated it with other clinicopathologic factors and clinical outcomes. p63 expression was observed in 42.5% of DLBCL, did not correlate with p53 levels, but correlated with … Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
2
2
1
0
14
0

Year Published

2016
2016
2018
2018

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

0
14
0
Order By: Relevance
“…Expression of p-AKT, IL-6, PI3K [34] , Myc [36] , p-STAT3 [37] , MDM2 [38] , p21 [39] , BLIMP-1 [40] , IgA and IgG [41] had been assessed by previous studies; the cutoff for p-AKT high expression (AKT hyperactivation) was ≥70% as described previously [34] .…”
Section: Methodsmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Expression of p-AKT, IL-6, PI3K [34] , Myc [36] , p-STAT3 [37] , MDM2 [38] , p21 [39] , BLIMP-1 [40] , IgA and IgG [41] had been assessed by previous studies; the cutoff for p-AKT high expression (AKT hyperactivation) was ≥70% as described previously [34] .…”
Section: Methodsmentioning
“…The TP63 gene (Chr.3q27–29) is approximately 65 kb and contains 15 exons ( 89 , 90 ). Like p73, p63 can activate many p53-target genes in response to oncogenic stress or DNA damage (Bax, 14-3-3σ, p53AIP1, IGF-BP3, p21 waf1 and cyclin G), it controls cell proliferation, apoptosis, differentiation and development, and shows a tissue-specific localization ( 79 , 91 94 ). p63 knockout mice exhibit a lethal phenotype soon after birth.…”
Section: Introductionmentioning
“…Therefore, we examined p63 expression and TP63 copy number in ALCL and found these to be correlated significantly. p63 expression also has been reported in B-cell lymphomas with or without TP63 rearrangements, but an association with TP63 copy number has not been reported [8, 17, 24–29]. Though our FISH approach did not allow precise mapping of the regions of chromosomal gain in ALCLs with extra copies of TP63 (on 3q28), this finding was associated significantly with extra copies of the DUSP22 locus on 6p25.3, suggesting aneuploidy rather than focal gains as the cause of these extra copies.…”
Section: Discussionmentioning
“…In fact, no exonic or junctional reads corresponding to a ΔNp63 isoform were identified. TAp63 isoforms have tumor suppressor properties in some experimental models, and their expression has been associated with favorable outcomes in diffuse large B-cell lymphoma [27, 29]. However, while TP63 rearrangements are associated with poor prognosis in ALCL, we previously reported a lack of significant differences in outcomes between p63 protein-positive and -negative cases [9].…”
Section: Discussionmentioning